Bisphosphonate treatment delays stress fracture remodeling in the rat ulna

Journal of Orthopaedic Research

Volumn 29, Issue 12, 2011, Pages 1827-1833

  Kidd, L J ^a   Cowling, N R ^a   Wu, A C K ^b   Kelly, W L ^b   Forwood, M R ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

bisphosphonate; bone remodeling; risedronate; stress fracture

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; RISEDRONIC ACID; SODIUM CHLORIDE; TOLUIDINE DERIVATIVE;

ARTICLE; BONE REMODELING; CALLUS; CONTROLLED STUDY; FEMALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PERIOSTEUM; PRIORITY JOURNAL; RAT; STRESS FRACTURE; ULNA FRACTURE; WISTAR RAT;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; BONY CALLUS; DIAPHYSES; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETIDRONIC ACID; FEMALE; FRACTURES, STRESS; PERIOSTEUM; RATS; RATS, WISTAR; ULNA FRACTURES;

EID: 80054709861     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21464     Document Type: Article

References (42)

1. Burr DB, Forwood MR, Fyhrie DP, et al. 1997. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 12: 6-15. (Pubitemid 27053606)
2. Lenart BA, Lorich DG, Lane JM,. 2008. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med 358: 1304-1306. (Pubitemid 351439247)
3. McDonald MM, Dulai S, Godfrey C, et al. 2008. Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone 43: 653-662.
4. Lenart BA, Neviaser AS, Lyman S, et al. 2009. Association of low-energy femoral fractures with prolonged bisphosphonate use: A case control study. Osteoporos Int 20: 1353-1362.
5. Neviaser AS, Lane JM, Lenart BA, et al. 2008. Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma 22: 346-350. (Pubitemid 351630250)
6. Bennell KL, Brukner PD,. 1997. Epidemiology and site specificity of stress fractures. Clin Sports Med 16: 179-196. (Pubitemid 27190626)
7. Martin B,. 1995. Mathematical model for repair of fatigue damage and stress fracture in osteonal bone. J Orthop Res 13: 309-316.
8. Milgrom C, Finestone A, Novack V, et al. 2004. The effect of prophylactic treatment with risedronate on stress fracture incidence among infantry recruits. Bone 35: 418-424. (Pubitemid 38953188)
9. Barrett JG, Sample SJ, McCarthy J, et al. 2007. Effect of short-term treatment with alendronate on ulnar bone adaptation to cyclic fatigue loading in rats. J Orthop Res 25: 1070-1077. (Pubitemid 47233083)
10. Stewart GW, Brunet ME, Manning MR, et al. 2005. Treatment of stress fractures in athletes with intravenous pamidronate. Clin J Sport Med 15: 92-94. (Pubitemid 40462883)
11. Schilcher J, Aspenberg P,. 2009. Incidence of stress fractures of the femoral shaft in women treated with bisphosphonate. Acta Orthop 80: 413-415.
12. Amanat N, Brown R, Bilston LE, et al. 2005. A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. J Orthop Res 23: 1029-1034. (Pubitemid 41245425)
13. Li J, Mori S, Kaji Y, et al. 1999. Effect of bisphosphonate (incadronate) on fracture healing of long bones in rats. J Bone Miner Res 14: 969-979. (Pubitemid 29262892)
14. Li J, Waugh LJ, Hui SL, et al. 2007. Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs have opposing effects during stress fracture repair. J Orthop Res 25: 1559-1567. (Pubitemid 350293803)
15. Kidd LJ, Stephens AS, Kuliwaba JS, et al. 2010. Temporal pattern of gene expression and histology of stress fracture healing. Bone 46: 369-378.
16. Sloan AV, Martin JR, Li S, et al. 2010. Parathyroid hormone and bisphosphonate have opposite effects on stress fracture repair. Bone 47: 235-240.
17. Uthgenannt BA, Silva MJ,. 2007. Use of the rat forelimb compression model to create discrete levels of bone damage in vivo. J Biomech 40: 317-324. (Pubitemid 44970464)
18. Tami AE, Nasser P, Schaffler MB, et al. 2003. Noninvasive fatigue fracture model of the rat ulna. J Orthop Res 21: 1018-1024. (Pubitemid 37322383)
19. Chapurlat RD, Delmas PD,. 2006. Drug insight: Bisphosphonates for postmenopausal osteoporosis. Nat Clin Pract Endocrinol Metab 2: 211-219; quiz following 238.
20. Forwood MR, Bennett MB, Blowers AR, et al. 1998. Modification of the in vivo four-point loading model for studying mechanically induced bone adaptation. Bone 23: 307-310. (Pubitemid 28434677)
21. Eastell R, Barton I, Hannon RA, et al. 2003. Relationship of early changes in bone resorption to the reduction in fracture risk with risedronate. J Bone Miner Res 18: 1051-1056. (Pubitemid 37294942)
22. Eriksen EF, Melsen F, Sod E, et al. 2002. Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis. Bone 31: 620-625. (Pubitemid 35449706)
23. Sato M, Grasser W, Endo N, et al. 1991. Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88: 2095-2105.
24. Hughes DE, MacDonald BR, Russell RG, et al. 1989. Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest 83: 1930-1935. (Pubitemid 19148862)
25. Boonekamp PM, van der Wee-Pals LJ, van Wijk-van Lennep MM, et al. 1986. Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix. Bone Miner 1: 27-39. (Pubitemid 16018095)
26. Lowik CW, van der Pluijm G, van der Wee-Pals LJ, et al. 1988. Migration and phenotypic transformation of osteoclast precursors into mature osteoclasts: The effect of a bisphosphonate. J Bone Miner Res 3: 185-192.
27. Ito M, Nishida A, Aoyagi K, et al. 2005. Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia. Osteoporos Int 16: 1042-1048. (Pubitemid 41225090)
28. Follet H, Li J, Phipps RJ, et al. 2007. Risedronate and alendronate suppress osteocyte apoptosis following cyclic fatigue loading. Bone 40: 1172-1177. (Pubitemid 46386562)
29. Plotkin LI, Manolagas SC, Bellido T,. 2006. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone 39: 443-452. (Pubitemid 44164640)
30. Nagashima M, Sakai A, Uchida S, et al. 2005. Bisphosphonate (YM529) delays the repair of cortical bone defect after drill-hole injury by reducing terminal differentiation of osteoblasts in the mouse femur. Bone 36: 502-511. (Pubitemid 40403848)
31. Iwata K, Li J, Follet H, et al. 2006. Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia. Bone 39: 1053-1058. (Pubitemid 44528380)
32. Schindeler A, Little DG,. 2005. Osteoclasts but not osteoblasts are affected by a calcified surface treated with zoledronic acid in vitro. Biochem Biophys Res Commun 338: 710-716. (Pubitemid 41597701)
33. Schindeler A, Little DG,. 2007. Bisphosphonate action: Revelations and deceptions from in vitro studies. J Pharm Sci 96: 1872-1878. (Pubitemid 47280088)
34. Hsieh YF, Silva MJ,. 2002. In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density. J Orthop Res 20: 764-771. (Pubitemid 34822996)
35. Silva MJ, Touhey DC,. 2007. Bone formation after damaging in vivo fatigue loading results in recovery of whole-bone monotonic strength and increased fatigue life. J Orthop Res 25: 252-261. (Pubitemid 46344251)
36. Amanat N, McDonald M, Godfrey C, et al. 2007. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res 22: 867-876. (Pubitemid 351339747)
37. Goodship AE, Walker PC, McNally D, et al. 1994. Use of a bisphosphonate (pamidronate) to modulate fracture repair in ovine bone. Ann Oncol 5 (Suppl 7): S53-S55.
38. Peter CP, Cook WO, Nunamaker DM, et al. 1996. Effect of alendronate on fracture healing and bone remodeling in dogs. J Orthop Res 14: 74-79. (Pubitemid 26091605)
39. Koivukangas A, Tuukkanen J, Kippo K, et al. 2003. Long-term administration of clodronate does not prevent fracture healing in rats. Clin Orthop Relat Res 408: 268-278. (Pubitemid 36307518)
40. Peris P,. 2003. Stress fractures. Best Pract Res Clin Rheumatol 17: 1043-1061. (Pubitemid 38324651)
41. Dallap BL, Bramlage LR, Embertson RM,. 1999. Results of screw fixation combined with cortical drilling for treatment of dorsal cortical stress fractures of the third metacarpal bone in 56 Thoroughbred racehorses. Equine Vet J 31: 252-257. (Pubitemid 129572408)
42. Uthgenannt BA, Kramer MH, Hwu JA, et al. 2007. Skeletal self-repair: Stress fracture healing by rapid formation and densification of woven bone. J Bone Miner Res 22: 1548-1556. (Pubitemid 351229325)