Efficient synthesis and antiproliferative activity of novel thioether-substituted flavonoids

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 161-170

  Huang, Wei ^a,b   Chen, Qiong ^a   Yang, Wen Chao ^a   Yang, Guang Fu ^a  

^a CENTRAL CHINA NORMAL UNIVERSITY   (China)

^b Jiangsu Simcere Pharmaceutical RandD Co Ltd   (China)

Author keywords

Antiproliferative activity; Chromone; Flavonoids; Microwave assisted synthesis; Thioether

Indexed keywords

2 [(4,6 DIMETHYLPYRIMIDIN 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(4,6 DIMETHYLPYRIMIDIN 2 YLTHIO)METHYL] 6 METHYL 4H CHROMEN 4 ONE; 2 [(5 AMINO 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(5 AMINO 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 6 CHLORO 4H CHROMEN 4 ONE; 2 [(5 AMINO 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 6 METHYL 4H CHROMEN 4 ONE; 2 [(5 METHYL 1,3,4 OXADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(5 METHYL 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(BENZO[D]THIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(BENZO[D]THIAZOL 2 YLTHIO)METHYL] 6 CHLORO 4H CHROMEN 4 ONE; 2 [(BENZO[D]THIAZOL 2 YLTHIO)METHYL] 6 METHYL 4H CHROMEN 4 ONE; 2 [[4 AMINO 5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 4H 1,2,4 TRIAZOL 3 YLTHIO] METHYL] 4H CHROMEN 4 ONE; 2 [[5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 1,3,4 THIADIAZOL 2 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 2 [[5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 4 PHENYL 4H 1,2,4 TRIAZOL 3 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 3 [(4,6 DIMETHYLPYRIMIDIN 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 3 [(5 METHYL 1,3,4 OXADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 3 [(5 METHYL 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 3 [[4 AMINO 5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]METHYL) 4H 1,2,4 TRIAZOL 3 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 3 [[5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO) METHYL] 1,3,4 THIADIAZOL 2 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 3 [[5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 4 PHENYL 4H 1,2,4 TRIAZOL 3 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 6 CHLORO 2 [(4,6 DIMETHYLPYRIMIDIN 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 6 CHLORO 2 [(5 METHYL 1,3,4 OXADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 6 CHLORO 2 [(5 METHYL 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 6 CHLORO 2 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 6 METHYL 2 [(5 METHYL 1,3,4 OXADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 6 METHYL 2 [(5 METHYL 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; ANTINEOPLASTIC AGENT; FLAVONOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; [2 [(5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 1,3,4 OXADIAZOL 2 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 2 [(5 AMINOL 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 2 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO) METHYL] 4H CHROMEN 4 ONE; 2 [[4 AMINO 5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL] 4H 1,2,4 TRIAZOL 3 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 2 [[5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2 YLTHIO)METHYL]1,3,4 OXADIAZOL 2 YLTHIO]METHYL] 4H CHROMEN 4 ONE; 2 [[5 [(5,7 DIMETHYL [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 2YLTHIO)METHYL] 4 PHENYL 4H 1,2,4 TRAIZOL 3 YLTHIO]METHYL] 4H CHROMEN ONE; 3 [(5 AMINO 1,3,4 THIADIAZOL 2 YLTHIO)METHYL] 4H CHROMEN 4 ONE; 6 METHYL 2 [(5 METHYL 1,3,4 OXADIAZOL 2 YLTHIO)METHYL]- 4H CHROMEN 4 ONE; 6 METHYL 2 [(5 METHYL 1,3,4 THIADIAZOL 2 YLTHIO)METHYL]- 4H CHROMEN 4 ONE; CHROMONE DERIVATIVE; FLUOROURACIL; SULFIDE; THIOETHER SUBSTITUTED FLAVONOID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; HELA CELL; HEP 2 CELL; HUMAN; HUMAN CELL; IC 50; MICROWAVE RADIATION; NITROBLUE TETRAZOLIUM TEST; BREAST ADENOCARCINOMA; CANCER CELL LINE; CLINICAL EVALUATION; COLON CARCINOMA; COLON CARCINOMA CELL LINE; COMPARATIVE STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; HELA CELL LINE; HEP 2 CELL LINE; HEPATOMA CARCINOMA CELL LINE; IC50; LIVER CELL CARCINOMA; MAMMARY ADENOCARCINOMA CELL LINE; MCF 7 CELL LINE; MTT ASSAY; REACTION TIME; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 84879229827     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.037     Document Type: Article

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