The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice

Immunology

Volumn 139, Issue 3, 2013, Pages 318-327

  Suzuki, Eiji ^a   Williams, Sarah ^b   Sato, Shuzo ^a   Gilkeson, Gary ^a,b   Watson, Dennis K ^a   Zhang, Xian K ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Dendritic cells; Fli 1 transcription factor; Fms related tyrosine kinase 3 ligand; Macrophages; Monocytes

Indexed keywords

CD135 ANTIGEN; TRANSCRIPTION FACTOR FLI 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN; STROMA CELL;

ANIMALS; BONE MARROW; CELL DIFFERENTIATION; CELL LINE; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; FMS-LIKE TYROSINE KINASE 3; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MONOCYTES; PROTO-ONCOGENE PROTEIN C-FLI-1; SPLEEN;

EID: 84879228689     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12070     Document Type: Article

References (39)

1. Geissmann F, Manz MG, Jung S, Sieweke MH, Meras M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010; 327:656-61.
2. Auffary C, Sieweke MH, Geissmass F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009; 27:66992.
3. Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009; 27:451-83.
4. Watowich SS, Liu Y. Mechanisms regulating dendritic cell specification and development. Immunol Rev 2010; 238:76-92.
5. Wu L, Liu Y. Development of dendritic-cell lineages. Immunity 2007; 26:741-50.
6. Blanco P, Paiucka AK, Banchereau J. Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 2008; 19:41-52.
7. Liu K, Victora GD, Schwickert TA et al. In vivo analysis of dendritic cell development and homeostasis. Science 2009; 324:392-97.
8. Chow A, Brown BD, Merad M. Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol 2011; 11:788-98.
9. Merad M, Manz MG. Dendritic cell homeostasis. Blood 2009; 113:3418-27.
10. Anderson KL, Perkin H, Surh CD, Venturini S, Maki RA, Torbett BE. Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J Immunol 2000; 164:1855-61.
11. Schotte R, Nagasawa M, Weijer K, Spits H, Blom B. The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med 2004; 200:1503-9.
12. Ben-David Y, Giddenns EB, Letwin K, Berstein A. Erythroleukemia induction by friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1. Genes Dev 1991; 5:908-18.
13. Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS, Seth A. The ERGB/Fli-1 gene: isolation and characterization of new member of the family of human ETS transcription factors. Cell Growth Differ 1992; 3:705-13.
14. Seth A, Ascino R, Fisher RS, Mavrothalassitis GJ, Bhat NB, Papas TS. The ets gene family. Cell growth Differ 1992; 3:327-34.
15. Papas TS, Bhat NK, Spyropoulos DD, Mjaatvedt AE, Vournakis J, Seth A, Watson DK. Functional relationships among ETS gene family members. Leukemia 1997; 11:557-66.
16. Karim FD, Urness LD, Thummel CS et al. The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev 1990; 4:1451-3.
17. Athanasiou M, Clausen PA, Mavrothalassitis GJ, Zhang XK, Watson DK, Blair DG. Increase expression of ETS-related transcriptional factor Fli-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth Differ 1996; 7:1525-34.
18. Lemarchndel V, Ghysdael J, Mignotte V, Rahuel C, Romeo PH. GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol Cell Biol 1993; 13:668-76.
19. Wang X, Crispino JD, Letting DL, Nakazawa M, Poncz M, Blobel GA. Control of megakariocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. EMBO J 2002; 21:225-34.
20. Jackers P, Szalai G, Moussa O, Watson DK. Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biochem 2004; 279:52183-190.
21. Szalai G, LaRue AC, Watson DK. Molecular mechanisms of megakaryopoiesis. Cell Mol Life Sci 2006; 63:2460-76.
22. Zhang XK, Moussa O, LaRue A, Bradshaw S, Molano I, Spyropoulos DD, Gilkeson GS, Watson DK. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol 2008; 81:1644-54.
23. Spyropoulos DD, Pharr PN, Lavenburg KR, Jackers P, Papas TS, Ogawa M, Watson DK. Hemorrhage, impaired hemotopoiesis and lethality in mouse embryos carrying a targeted disruption of Fli-1 transcription factor. Mol Cell Biol 2000; 20:5643-52.
24. Moussa O, LaRue AC, Abangan RS et al. Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of Ets transcription factor Fli-1. Mol Cell Biol 2010; 30:5194-206.
25. Georgiou P, Maroulakou IG, Green JE et al. Expression of ets family of genes in systemic lupus erythematosus and Sjögren's syndrome. Int J Oncol 1996; 9:9-18.
26. Zhang XK, Gallant S, Molano I, Moussa OM, Ruiz P, Spyropoulos DD, Watson DK, Gilkeson G. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol 2004; 173:6481-9.
27. Mathenia J, Reyes-Cortes E, Williams S, Molano I, Ruiz P, Watson DK, Gilkeson GS, Zhang XK. Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice. Clin Exp Immunol 2010; 162:362-71.
28. Kawada H, Ito T, Pharr PN, Spyropoulos DD, Watson DK, Ogawa M. Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol 2001; 73:463-8.
29. Masuya M, Moussa O, Abe T et al. Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice. Blood 2005; 105:95-102.
30. Starck J, Weiss-Gayet M, Gonnet C, Guyot B, Vicat JM, Morle F. Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrotic differentiation. Blood 2010; 23:4795-805.
31. Bradshaw S, Zheng WJ, Tsoi LC, Gilkeson G, Zhang XK. A role for Fli-1 in B cell proliferation: implication for SLE pathogenesis. Clin Immunol 2008; 129:19-30.
32. Vremec D, Pooley J, Hochrein H, Wu L, Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol 2000; 164:2978-86.
33. Fukui Y, Hashimoto O. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 2001; 412:826-31.
34. Weih DS, Yilmaz ZB, Weih F. Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J Immunol 2001; 167:1909-19.
35. Gabriele L, Ozato K. The role of the interferon regulatory factor (IRF) family in dendritic cell development and function. Cytokine Growth Factor Rev 2007; 18:503-10.
36. Vremec D, Lieschke GJ, Dunn AR, Robb L, Metcalf D, Shortman K. The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lyphoid organs. Eur J Immunol 1997; 27:40-4.
37. high murine dendritic cells in vivo: a comparative analysis with Flt3 ligand. J Immunol 2000; 165:49-58.
38. Maraskovskt E, Brasel K, Teepe M, Roux ER, Lyman SD, Shortman K, McKenna HJ. Dramatic increase in the number of functionally mature dendritc cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med 1996; 184:1953-62.
39. Laouar Y, Welte T, Fu XY, Flavell RA. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity 2003; 19:903-12.