메뉴 건너뛰기




Volumn 42, Issue 6-7, 2010, Pages 527-532

Raltegravir as functional monotherapy leads to virological failure and drug resistance in highly treatment-experienced HIV-infected patients

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; DARUNAVIR; ENFUVIRTIDE; ETRAVIRINE; INTEGRASE; MARAVIROC; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RALTEGRAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TIPRANAVIR; VIRUS RNA; 2 PYRROLIDONE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

EID: 77953263347     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365541003621502     Document Type: Article
Times cited : (13)

References (22)
  • 2
    • 33847041109 scopus 로고    scopus 로고
    • Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1
    • Katlama C, Esposito R, Gatell JM, Goffard JC, Grinsztejn B, Pozniak A, et al. Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1. AIDS 2007;21:395-402.
    • (2007) AIDS , vol.21 , pp. 395-402
    • Katlama, C.1    Esposito, R.2    Gatell, J.M.3    Goffard, J.C.4    Grinsztejn, B.5    Pozniak, A.6
  • 3
    • 34047205841 scopus 로고    scopus 로고
    • Week 24 efficacy and safety of TMC114/ ritonavir in treatment-experienced HIV patients
    • Haubrich R, Berger D, Chiliade P, Colson A, Conant M, Gallant J, et al. Week 24 efficacy and safety of TMC114/ ritonavir in treatment-experienced HIV patients. AIDS 2007;21:F11-8.
    • (2007) AIDS , vol.21
    • Haubrich, R.1    Berger, D.2    Chiliade, P.3    Colson, A.4    Conant, M.5    Gallant, J.6
  • 4
    • 85069127186 scopus 로고    scopus 로고
    • Week-48 results of a phase III randomized doubleblind trial to evaluate the efficacy and safety of TMC125 vs placebo in 591 treatment-experienced HIV-1 patients
    • (poster presentation). Boston USA
    • Johnson M. Week-48 results of a phase III randomized doubleblind trial to evaluate the efficacy and safety of TMC125 vs placebo in 591 treatment-experienced HIV-1 patients. Conference on Retroviruses and Opportunistic Infections (poster presentation). Boston, USA; 2008.
    • (2008) Conference on Retroviruses and Opportunistic Infections
    • Johnson, M.1
  • 6
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
    • Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr 2007;46:125-133
    • (2007) J Acquir Immune Defic Syndr , vol.46 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3    Mendo, F.4    Ratanasuwan, W.5    Kovacs, C.6
  • 7
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection (oral abstract session)
    • Cooper DA, Steigbigel RT, Gatell JM, Rockstroh JK, Katlama C, Yeni P, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection (oral abstract session). N Engl J Med 2008;359:355-365
    • (2008) N Engl J Med , vol.359 , pp. 355-365
    • Cooper, D.A.1    Steigbigel, R.T.2    Gatell, J.M.3    Rockstroh, J.K.4    Katlama, C.5    Yeni, P.6
  • 8
    • 55049098133 scopus 로고    scopus 로고
    • High rate of virologic success with raltegravir plus etravirine and darunavir/ritonavir in treatmentexperienced patients with multidrug-resistant virus: Results of the ANRS 139 TRIO trial
    • (oral abstract session). Mexico
    • Yazdanpanah Y. high rate of virologic success with raltegravir plus etravirine and darunavir/ritonavir in treatmentexperienced patients with multidrug-resistant virus: results of the ANRS 139 TRIO trial. XVII International AIDS Conference (oral abstract session). Mexico; 2008.
    • (2008) XVII International AIDS Conference
    • Yazdanpanah, Y.1
  • 9
    • 0242331663 scopus 로고    scopus 로고
    • Predictors of the virological response to a change in the antiretroviral treatment regimen in HIV- 1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088)
    • Vray M, Meynard JL, Dalban C, Morand-Joubert L, Clavel F, Brun-Vezinet F, et al. Predictors of the virological response to a change in the antiretroviral treatment regimen in HIV- 1-infected patients enrolled in a randomized trial comparing genotyping, phenotyping and standard of care (Narval trial, ANRS 088). Antivir Ther 2003;8:427-434
    • (2003) Antivir Ther , vol.8 , pp. 427-434
    • Vray, M.1    Meynard, J.L.2    Dalban, C.3    Morand-Joubert, L.4    Clavel, F.5    Brun-Vezinet, F.6
  • 10
    • 17744418262 scopus 로고    scopus 로고
    • Predictors of virological success and ensuing failure in HIV-positive patients starting highly active antiretroviral therapy in Europe: Results from the EuroSIDA study
    • Paredes R, Mocroft A, Kirk O, Lazzarin A, Barton SE, van Lunzen J, et al. Predictors of virological success and ensuing failure in HIV-positive patients starting highly active antiretroviral therapy in Europe: results from the EuroSIDA study. Arch Intern Med 2000;160:1123-1132
    • (2000) Arch Intern Med , vol.160 , pp. 1123-1132
    • Paredes, R.1    Mocroft, A.2    Kirk, O.3    Lazzarin, A.4    Barton, S.E.5    Van Lunzen, J.6
  • 11
    • 0032787511 scopus 로고    scopus 로고
    • Incidence and predictors of virologic failure of antiretroviral triple-drug therapy in a community-based cohort
    • Paris D, Ledergerber B, Weber R, Jost J, Flepp M, Opravil M, et al. Incidence and predictors of virologic failure of antiretroviral triple-drug therapy in a community-based cohort. AIDS Res Hum Retroviruses 1999;15:1631-1638
    • (1999) AIDS Res Hum Retroviruses , vol.15 , pp. 1631-1638
    • Paris, D.1    Ledergerber, B.2    Weber, R.3    Jost, J.4    Flepp, M.5    Opravil, M.6
  • 12
    • 0032581604 scopus 로고    scopus 로고
    • Predictors of long-term response to protease inhibitor therapy in a cohort of HIV-infected patients
    • Casado JL, Perez-Elias MJ, Antela A, Sabido R, Marti-Belda P, Dronda F, et al. Predictors of long-term response to protease inhibitor therapy in a cohort of HIV-infected patients. AIDS 1998;12:F131-5.
    • (1998) AIDS , vol.12
    • Casado, J.L.1    Perez-Elias, M.J.2    Antela, A.3    Sabido, R.4    Marti-Belda, P.5    Dronda, F.6
  • 13
    • 0037016424 scopus 로고    scopus 로고
    • Predictors of virological rebound in HIV- 1-infected patients initiating a protease inhibitor-containing regimen
    • Le Moing V, Chene G, Carrieri MP, Alioum A, Brun-Vezinet F, Piroth L, et al. Predictors of virological rebound in HIV- 1-infected patients initiating a protease inhibitor-containing regimen. AIDS 2002;16:21-29
    • (2002) AIDS , vol.16 , pp. 21-29
    • Le Moing, V.1    Chene, G.2    Carrieri, M.P.3    Alioum, A.4    Brun-Vezinet, F.5    Piroth, L.6
  • 14
    • 84857239027 scopus 로고    scopus 로고
    • Panel on antiretroviral guidelines for adults and adolescents
    • Washington DC: Department of Health and Human Services; . Available at, Accessed date: December 1, 2009
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. USA guidelines for the use of antiretroviral agents in HIV- 1-infected adults and adolescents. Washington DC: Department of Health and Human Services; 2009. Available at: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL. Accessed date: December 1, 2009.
    • (2009) USA Guidelines for the Use of Antiretroviral Agents in HIV- 1-infected Adults and Adolescents
  • 15
    • 85069127468 scopus 로고    scopus 로고
    • Prise en charge médicale des personnes infectées par le VIH
    • Publisher: flammarion. August 22, Available at: accessed date: august 19, 2008
    • Prise en charge médicale des personnes infectées par le VIH. Publisher: flammarion. Recommandations françaises du groupe d'experts sous la direction du Professeur P. YENI. August 22, 2008. Available at: http://www.sante.gouv.fr accessed date: august 19, 2008.
    • (2008) Recommandations Françaises du Groupe d'Experts Sous la Direction du Professeur P. YENI
  • 17
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • Malet I, Delelis O, Valantin MA, Montes B, Soulie C, Wirden M, et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother 2008;52:1351-1358
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1351-1358
    • Malet, I.1    Delelis, O.2    Valantin, M.A.3    Montes, B.4    Soulie, C.5    Wirden, M.6
  • 18
    • 7744240084 scopus 로고    scopus 로고
    • Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
    • Fikkert V, Hombrouck A, Van Remoortel B, De Maeyer M, Pannecouque C, De Clercq E, et al. Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS 2004;18:2019-2028
    • (2004) AIDS , vol.18 , pp. 2019-2028
    • Fikkert, V.1    Hombrouck, A.2    Van Remoortel, B.3    De Maeyer, M.4    Pannecouque, C.5    De Clercq, E.6
  • 19
    • 48449083017 scopus 로고    scopus 로고
    • HIV-1 drug resistance mutations: An updated framework for the second decade of HAART
    • Shafer RW, Schapiro JM. HIV-1 drug resistance mutations: an updated framework for the second decade of HAART. AIDS Rev 2008;10:67-84.
    • (2008) AIDS Rev , vol.10 , pp. 67-84
    • Shafer, R.W.1    Schapiro, J.M.2
  • 20
    • 34447263572 scopus 로고    scopus 로고
    • Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
    • Lataillade M, Chiarella J, Kozal MJ. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance. Antivir Ther 2007;12: 563-570
    • (2007) Antivir Ther , vol.12 , pp. 563-570
    • Lataillade, M.1    Chiarella, J.2    Kozal, M.J.3
  • 21
    • 68949186494 scopus 로고    scopus 로고
    • Switching from stable lopinavir/ritonavir (LPV/r)-based to raltegravir (RAL)-based combination antiretroviral therapy (ART) resulted in a superior lipid profile at week 12 but did not demonstrate non-inferior virologic efficacy at week 24
    • (oral abstract session). Montreal Canada
    • Eron J. Switching from stable lopinavir/ritonavir (LPV/r)-based to raltegravir (RAL)-based combination antiretroviral therapy (ART) resulted in a superior lipid profile at week 12 but did not demonstrate non-inferior virologic efficacy at week 24. Conference on Retroviruses and Opportunistic Infections (oral abstract session). Montreal, Canada; 2009.
    • (2009) Conference on Retroviruses and Opportunistic Infections
    • Eron, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.