Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by indole alkaloid, 3-(hydroxymethyl)-6,7-dihydroindolo[2,3-a]quinolizin-(12H)-one, via NF- κ B inactivation in RAW 2647 macrophages

Planta Medica

Volumn 79, Issue 9, 2013, Pages 782-787

  Zhao, Feng ^a   Chen, Lei ^a   Zhang, Menglin ^a   Bi, Chenchen ^a   Li, Lichun ^a   Zhang, Qingzhen ^a   Shi, Cuicui ^a   Li, Miao ^a   Zhou, Songsong ^a   Kong, Linghua ^a  

^a YANTAI UNIVERSITY   (China)

Author keywords

anti inflammatory effect; indole alkaloid; Nauclea officinalis; Rubiaceae

Indexed keywords

3 (HYDROXYMETHYL) 6,7 DIHYDROINDOLO[2,3 A]QUINOLIZIN (12H) ONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE ALKALOID; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; MACROPHAGE; MEDICINAL PLANT; MOLECULAR MECHANICS; NAUCLEA ORIENTALIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL NUCLEUS; CELLS, CULTURED; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; INDOLE ALKALOIDS; INDOLES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN TRANSPORT; QUINOLIZINES; RUBIACEAE; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; NAUCLEA; RUBIACEAE;

EID: 84879207928     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328550     Document Type: Article

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