Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight

Osteoporosis International

Volumn 24, Issue 7, 2013, Pages 2105-2114

  LeBlanc, A ^a   Matsumoto, T ^b   Jones, J ^c   Shapiro, J ^d   Lang, T ^e   Shackelford, L ^f   Smith, S M ^f   Evans, H ^g   Spector, E ^g   Ploutz Snyder, R ^a   Sibonga, J ^f   Keyak, J ^h   Nakamura, T ⁱ   Kohri, K ^j   Ohshima, H ^k  

^a UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d KENNEDY KRIEGER INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f NASA JOHNSON SPACE CENTER   (United States)

^g WYLE LABORATORIES   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^j NAGOYA CITY UNIVERSITY   (Japan)

^k JAPAN AEROSPACE EXPLORATION AGENCY   (Japan)

more..

Author keywords

Bisphosphonates; Bone loss; Computed bone strength; Exercise; QCT; Spaceflight

Indexed keywords

ALENDRONIC ACID; CALCIUM;

ADULT; ARTICLE; BICYCLE ERGOMETER; BONE MASS; BONE METABOLISM; BONE STRENGTH; CALCIUM URINE LEVEL; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; COSMONAUT; DENSITOMETRY; DIET SUPPLEMENTATION; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FEMALE; HUMAN; MALE; NEPHROLITHIASIS; OSTEOLYSIS; PRIORITY JOURNAL; RESISTANCE TRAINING; SPACE FLIGHT; TREADMILL EXERCISE;

ABSORPTIOMETRY, PHOTON; ADULT; ALENDRONATE; BIOLOGICAL MARKERS; BODY COMPOSITION; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; EXERCISE THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; SPACE FLIGHT; WEIGHTLESSNESS;

EID: 84879200560     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2243-z     Document Type: Article

References (41)

1. Rambaut PC, Johnston RS (1979) Prolonged weightlessness and calcium loss in man. Acta Astronaut 6:1113-1122
2. Rambaut PC, Leach CS, Whedon GD (1979) A study of metabolic balance in crewmembers of Skylab IV. Acta Astronaut 6(10):1313-1322
3. Whedon GD, Lutwak L, Rambaut PC, Whittle MW, Smith MC, Reid J, Leach C, Stadler CR, Sanford DD (1977) Mineral and nitrogen metabolic studies, experiment M071. In: Johnston RS, Dietlein LF (eds) Biomedical results from Skylab (NASA SP-377). National Aeronautics and Space Administration, Washington, DC, pp 164-174
4. Smith SM, Nillen JL, LeBlanc A, Lipton A, Demers LM, Lane HW, Leach CS (1998) Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 83(10):3584-3591
5. Nicogossian AE, Sawin CF, Grigoriev AI (1994) Countermeasures to space deconditioning. In: Nicogossian AE, Huntoon CL, Pool SL (eds) Space physiology and medicine, 3rd edn. Lea & Febiger, Philadelphia, pp 447-467
6. Oganov VS, Grigoriev AI, Voronin LI, Rakhmanov AS, Bakulin AV, Schneider VS, LeBlanc AD (1992) Bone mineral density in cosmonauts after flights lasting 4.5-6 months on the Mir orbital station. Aviakosm Ekolog Med 26(5-6):20-24
7. LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A, Voronin L (2000) Bone mineral and lean tissue loss after long duration space flight. J Musculoskelet Neuronal Interact 1:157-160
8. LeBlanc A, Schneider V, Spector E, Evans H, Rowe R, Lane H, Demers L, Lipton A (1995) Calcium absorption, endogenous excretion, and endocrine changes during and after long-term bed rest. Bone 16(4 Suppl):301S-304S
9. Smith SM, Wastney ME, O'Brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC (2005) Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the Mir space station. J Bone Miner Res 20(2):208-218
10. Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A (2004) Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19(6):1006-1012
11. Keyak JH, Koyama AK, LeBlanc A, Lu Y, Lang TF (2009) Reduction in proximal femoral strength due to long-duration spaceflight. Bone 44(3):449-453
12. Loehr JA, Lee SM, English KL, Sibonga J, Smith SM, Spiering BA, Hagan RD (2011) Musculoskeletal adaptations to training with the advanced resistive exercise device. Med Sci Sports Exerc 43(1):146-156
13. Schneider SM, Amonette WE, Blazine K, Bentley J, Lee SM, Loehr JA, Moore AD Jr, Rapley M, Mulder ER, Smith SM (2003) Training with the International Space Station interim resistive exercise device. Med Sci Sports Exerc 35(11):1935-1945
14. Hilliard-Robertson PC, Schneider SM, Bishop SL, Guilliams ME (2003) Strength gains following different combined concentric and eccentric exercise regimens. Aviat Space Environ Med 74(4):342-347
15. Smith SM, Heer MA, Shackelford L, Sibonga JD, Ploutz-Snyder L, Zwart SR (2012) Benefits for bone from resistance exercise and nutrition in long-duration spaceflight: evidence from biochemistry and densitometry. J Bone Miner Res 27(9):1896-1906
16. Shackelford LC, LeBlanc AD, Driscoll TB, Evans HJ, Rianon NJ, Smith SM, Spector E, Feeback DL, Lai D (2004) Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 97(1):119-129
17. LeBlanc AD, Driscol TB, Shackelford LC, Evans HJ, Rianon NJ, Smith SM, Feeback DL, Lai D (2002) Alendronate as an effective countermeasure to disuse induced bone loss. J Musculoskelet Neuronal Interact 2(4):335-343
18. Watanabe Y, Ohshima H, Mizuno K, Sekiguchi C, Fukunaga M, Kohri K, Rittweger J, Felsenberg D, Matsumoto T, Nakamura T (2004) Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90-day bed rest. J Bone Miner Res 19(11):1771-1778
19. Shapiro J, Smith B, Beck T, Ballard P, Dapthary M, Brintzenhofeszoc K, Caminis J (2007) Treatment with zoledronic acid ameliorates negative geometric changes in the proximal femur following acute spinal cord injury. Calcif Tissue Int 80(5):316-322, 2007
20. LeBlanc AD, Evans HJ, Marsch C, Schneider V, Johnson PC, Jhingran SG (1986) Precision of dual photon absorptiometry measurements. J Nucl Med 27(8):1362-1365
21. LeBlanc AD, Schneider VS, Engelbretson DA, Evans HJ (1990) Precision of regional bone mineral measurements obtained from total-body scans. J Nucl Med 31:43-45
22. Spector E, LeBlanc A, Shackelford L (1995) Hologic QDR 2000 whole-body scans: a comparison of three combinations of scan modes and analysis software. Osteoporos Int 5(6):440-445
23. Lang TF, Leblanc AD, Evans HJ, Lu Y (2006) Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res 21(8):1224-1230
24. Keyak JH, Kaneko TS, Tehranzadeh J, Skinner HB (2005) Predicting proximal femoral strength using structural engineering models. Clin Orthop Relat Res Aug 437:219-228
25. Keyak JH, Lang TF (2012) Finite element modeling of proximal femoral load capacity under fall loading. Trans Orthop Res Soc 37:0189
26. Carpenter RD, LeBlanc AD, Evans HJ, Sibonga JD, Lang T (2010) Long-term changes in the density and structure of the human hip and spine after long-duration spaceflight. Acta Astronaut 67:71-81
27. Amin S, Kopperdhal DL, Melton LJ 3rd, Achenbach SJ, Therneau TM, Riggs BL, Keaveny TM, Khosla S (2011) Association of hip strength estimates by finite-element analysis with fractures in women and men. J Bone Miner Res 26(7):1593-1600
28. Frost HM (1982) Mechanical determinants of bone remodeling. Metab Bone Dis Relat Res 4(4):217-229
29. Scheuring RA, Mathers CH, Jones JA, Wear ML (2009) Musculoskeletal injuries and minor trauma in space: incidence and injury mechanisms in U.S. astronauts. Aviat Space Environ Med 80(2):117-124
30. Johnston SL, Campbell MR, Scheuring R, Feiveson AH (1994) Risk of herniated nucleus pulposus among U.S. astronauts. Aviat Space Environ Med 81(6):566-574
31. LeBlanc AD, Evans HJ, Schneider VS, Wendt RE 3rd, Hedrick TD (1994) Changes in intervertebral disc cross-sectional area with bed rest and space flight. Spine 19(7):812-817
32. Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, Fogarty J, Tarver WJ, Dervay JP, Hamilton DR, Sargsyan A, Phillips JL, Tran D, Lipsky W, Choi J, Stern C, Kuyumjian R, Polk JD (2011) Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology 118(10):2058-2069
33. Pietrzyk RA, Jones JA, Sams CF, Whitson PA (2007) Renal stone formation among astronauts. Aviat Space Environ Med 78(4 Suppl):A9-A13
34. Whitson PA, Pietrzyk RA, Jones JA, Nelman-Gonzalez M, Hudson EK, Sams CF (2009) Effect of potassium citrate therapy on the risk of renal stone formation during spaceflight. J Urol 182(5):2490-2496
35. LeBlanc AD, Spector ER, Evans HJ, Sibonga JD (2007) Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact 7(1):33-47
36. Okada A, Ohshima H, Itoh Y, Yasui T, Tozawa K, Kohri K (2008) Risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate and increased by resistive exercise. Int J Urol 15(7):630-635
37. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B (2012) American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw - 2009 update. Aust Endod J 35(3):119-130
38. Abrahamsen B, Einhorn TA (2012) Beyond a reasonable doubt? Bisphosphonates and atypical femur fractures. Bone 50(5):1196-1200
39. Feldstein AC, Black D, Perrin N, Rosales AG, Friess D, Boardman D, Dell R, Santora A, Chandler JM, Rix MM, Orwoll E (2012) Incidence and demography of femur fractures with and without atypical fractures. J Bone Miner Res 27(5):977-986.37
40. Lewiecki EM (2011) Safety and tolerability of denosumab for the treatment of postmenopausal osteoporosis. Drug Health Patient Safety 3:79-91
41. Akhtar NH, Afzal MZ, Ahmed AA (2011) Osteonecrosis of jaw with the use of denosumab. J Cancer Res Ther 7(4):499-500