Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1831, Issue 8, 2013, Pages 1402-1411

  Nakaya, Kazuhiro ^a   Ayaori, Makoto ^a   Uto Kondo, Harumi ^a   Sotherden, Grace Megumi ^a   Nishida, Takafumi ^a   Katamoto, Haruka ^b   Miura, Yuko ^b   Takiguchi, Shunichi ^a   Yakushiji, Emi ^a   Iizuka, Maki ^a   Ogura, Masatsune ^a   Sasaki, Makoto ^a   Yogo, Makiko ^a   Komatsu, Tomohiro ^a   Adachi, Takeshi ^a   Maruyama, Chizuko ^b   Ikewaki, Katsunori ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b JAPAN WOMEN'S UNIVERSITY   (Japan)

Author keywords

HDL; Macrophage; Reverse cholesterol transport; SCD1

Indexed keywords

ACYL COENZYME A DESATURASE 1; ADENOVIRUS VECTOR; APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; MICRORNA; ABC TRANSPORTER; ABC TRANSPORTER A1; ABCG1 PROTEIN, MOUSE; ACYL COENZYME A DESATURASE; CHOLESTEROL; SCD1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL TRANSPORT; CLONING; CONTROLLED STUDY; FATTY ACID ANALYSIS; GENE OVEREXPRESSION; IN VITRO STUDY; MACROPHAGE; MEASUREMENT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; ACTIVE TRANSPORT; ANIMAL; ATHEROSCLEROSIS; BIOSYNTHESIS; CELL LINE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CHOLESTEROL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPOPROTEINS; LIPOPROTEINS, HDL; MACROPHAGES; MICE; STEAROYL-COA DESATURASE;

EID: 84879194684     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2013.05.009     Document Type: Article

References (34)

1. D. Duffy, D.J. Rader, Update on strategies to increase HDL quantity and function, Nat. Rev. Cardiol. 6 (2009) 455-463.
2. D.J. Rader, E.T. Alexander, G.L. Weibel, J. Billheimer, G.H. Rothblat, The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis, J. Lipid Res. 50 (Suppl.) (2009) S189-S194.
3. A.V. Khera, M. Cuchel, M. de la Llera-Moya, A. Rodrigues, M.F. Burke, K. Jafri, B.C. French, J.A. Phillips, M.L. Mucksavage, R.L. Wilensky, E.R. Mohler, G.H. Rothblat, D.J. Rader, Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis, N. Engl. J. Med. 364 (2011) 127-135.
4. M. Miyazaki, Y.C. Kim, M.P. Gray-Keller, A.D. Attie, J.M. Ntambi, The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1, J. Biol. Chem. 275 (2000) 30132-30138.
5. J.M. Landau, A. Sekowski, M.W. Hamm, Dietary cholesterol and the activity of stearoyl CoA desaturase in rats: evidence for an indirect regulatory effect, Biochim. Biophys. Acta 1345 (1997) 349-357. (Pubitemid 27171211)
6. J.M. Ntambi, M. Miyazaki, J.P. Stoehr, H. Lan, C.M. Kendziorski, B.S. Yandell, Y. Song, P. Cohen, J.M. Friedman, A.D. Attie, Loss of stearoyl-CoA desaturase-1 function protectsmice against adiposity, Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 11482-11486. (Pubitemid 34920951)
7. P. Cohen, M. Miyazaki, N.D. Socci, A. Hagge-Greenberg, W. Liedtke, A.A. Soukas, R. Sharma, L.C. Hudgins, J.M. Ntambi, J.M. Friedman, Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss, Science 297 (2002) 240-243. (Pubitemid 34761283)
8. J.M. Brown, S. Chung, J.K. Sawyer, C. Degirolamo, H.M. Alger, T. Nguyen, X. Zhu, M.N. Duong, A.L. Wibley, R. Shah, M.A. Davis, K. Kelley, M.D. Wilson, C. Kent, J.S. Parks, L.L. Rudel, Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis, Circulation 118 (2008) 1467-1475.
9. M.L. MacDonald, M. van Eck, R.B. Hildebrand, B.W. Wong, N. Bissada, P. Ruddle, A. Kontush, H. Hussein, M.A. Pouladi, M.J. Chapman, C. Fievet, T.J. van Berkel, B. Staels, B.M. McManus, M.R. Hayden, Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis, Arterioscler. Thromb. Vasc. Biol. 29 (2009) 341-347.
10. V. Savransky, J. Jun, J. Li, A. Nanayakkara, S. Fonti, A.B. Moser, K.E. Steele, M.A. Schweitzer, S.P. Patil, S. Bhanot, A.R. Schwartz, V.Y. Polotsky, Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase, Circ. Res. 103 (2008) 1173-1180.
11. S.B. Joseph, E. McKilligin, L. Pei, M.A. Watson, A.R. Collins, B.A. Laffitte, M. Chen, G. Noh, J. Goodman, G.N. Hagger, J. Tran, T.K. Tippin, X. Wang, A.J. Lusis, W.A. Hsueh, R.E. Law, J.L. Collins, T.M. Willson, P. Tontonoz, Synthetic LXR ligand inhibits the development of atherosclerosis in mice, Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 7604-7609. (Pubitemid 34568738)
12. K. Chu, M. Miyazaki, W.C. Man, J.M. Ntambi, Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma highdensity lipoprotein cholesterol induced by liver X receptor activation, Mol. Cell. Biol. 26 (2006) 6786-6798. (Pubitemid 44387629)
13. Y. Sun, M. Hao, Y. Luo, C.P. Liang, D.L. Silver, C. Cheng, F.R. Maxfield, A.R. Tall, Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure, J. Biol. Chem. 278 (2003) 5813-5820. (Pubitemid 36800827)
14. K. Nakaya, M. Ayaori, H. Uto-Kondo, T. Hisada, M. Ogura, E. Yakushiji, S. Takiguchi, Y. Terao, H. Ozasa, M. Sasaki, T. Komatsu, F. Ohsuzu, K. Ikewaki, Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo, Atherosclerosis 213 (2010) 135-141.
15. H. Uto-Kondo, M. Ayaori, M. Ogura, K. Nakaya, M. Ito, A. Suzuki, S. Takiguchi, E. Yakushiji, Y. Terao, H. Ozasa, T. Hisada, M. Sasaki, F. Ohsuzu, K. Ikewaki, Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages, Circ. Res. 106 (2010) 779-787.
16. Y. Terao, M. Ayaori, M. Ogura, E. Yakushiji, H. Uto-Kondo, T. Hisada, H. Ozasa, S. Takiguchi, K. Nakaya, M. Sasaki, T. Komatsu, M. Iizuka, S. Horii, S. Mochizuki, M. Yoshimura, K. Ikewaki, Effect of sulfonylurea agents on reverse cholesterol transport in vitro and vivo, J. Atheroscler. Thromb. 18 (2011) 513-530.
17. T. Iso, V. Sartorelli, C. Poizat, S. Iezzi, H.Y. Wu, G. Chung, L. Kedes, Y. Hamamori, HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling, Mol. Cell. Biol. 21 (2001) 6080-6089. (Pubitemid 32737822)
18. M. Ogura, M. Ayaori, Y. Terao, T. Hisada, M. Iizuka, S. Takiguchi, H. Uto-Kondo, E. Yakushiji, K. Nakaya, M. Sasaki, T. Komatsu, H. Ozasa, F. Ohsuzu, K. Ikewaki, Proteasomal inhibition promotes ATP-binding cassette transporter A1 (ABCA1) and ABCG1 expression and cholesterol efflux from macrophages in vitro and in vivo, Arterioscler. Thromb. Vasc. Biol. 31 (2011) 1980-1987.
19. N. Iwamoto, S. Abe-Dohmae, M. Ayaori, N. Tanaka, M. Kusuhara, F. Ohsuzu, S. Yokoyama, ATP-binding cassette transporter A1 gene transcription is downregulated by activator protein 2alpha. Doxazosin inhibits activator protein 2alpha and increases high-density lipoprotein biogenesis independent of alpha1-adrenoceptor blockade, Circ. Res. 101 (2007) 156-165. (Pubitemid 47196583)
20. M. Miyazaki, M.J. Jacobson, W.C. Man, P. Cohen, E. Asilmaz, J.M. Friedman, J.M. Ntambi, Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors, J. Biol. Chem. 278 (2003) 33904-33911. (Pubitemid 37553224)
21. J. Folch, M. Lees, G.H. Sloane Stanley, A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem. 226 (1957) 497-509.
22. C. Maruyama, M. Yoneyama, N. Suyama, K. Yoshimi, A. Teramoto, Y. Sakaki, Y. Suto, K. Takahashi, R. Araki, Y. Ishizaka, M. Yamakado, T. Teramoto, Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome, J. Atheroscler. Thromb. 15 (2008) 306-313.
23. B. Vogelstein, D. Lane, A.J. Levine, Surfing the p53 network, Nature 408 (2000) 307-310.
24. T. Yasuda, D. Grillot, J.T. Billheimer, F. Briand, P. Delerive, S. Huet, D.J. Rader, Tissue-specific liver X receptor activation promotesmacrophage reverse cholesterol transport in vivo, Arterioscler. Thromb. Vasc. Biol. 30 (2010) 781-786.
25. Y. Zhao, T.J. Van Berkel, M. Van Eck, Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions, Curr. Opin. Lipidol. 21 (2010) 441-453.
26. W. Le Goff, P. Zheng, G. Brubaker, J.D. Smith, Identification of the cAMPresponsive enhancer of the murine ABCA1 gene: requirement for CREB1 and STAT3/4 elements, Arterioscler. Thromb. Vasc. Biol. 26 (2006) 527-533.
27. M. Miyazaki, M.T. Flowers, H. Sampath, K. Chu, C. Otzelberger, X. Liu, J.M. Ntambi, Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis, Cell Metab. 6 (2007) 484-496. (Pubitemid 350163054)
28. J.M. Brown, S. Chung, J.K. Sawyer, C. Degirolamo, H.M. Alger, T.M. Nguyen, X. Zhu, M.N. Duong, A.L. Brown, C. Lord, R. Shah, M.A. Davis, K. Kelley, M.D. Wilson, J. Madenspacher, M.B. Fessler, J.S. Parks, L.L. Rudel, Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis, Arterioscler. Thromb. Vasc. Biol. 30 (2010) 24-30.
29. J.M. Brown, L.L. Rudel, Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery, Curr. Opin. Lipidol. 21 (2010) 192-197.
30. S. Lund-Katz, H.M. Laboda, L.R. McLean, M.C. Phillips, Influence ofmolecular packing and phospholipid type on rates of cholesterol exchange, Biochemistry 27 (1988) 3416-3423.
31. N. Wang, D.L. Silver, C. Thiele, A.R. Tall, ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein, J. Biol. Chem. 276 (2001) 23742-23747.
32. B.F. Asztalos, D. Collins, L.A. Cupples, S. Demissie, K.V. Horvath, H.E. Bloomfield, S.J. Robins, E.J. Schaefer, Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial, Arterioscler. Thromb. Vasc. Biol. 25 (2005) 2185-2191. (Pubitemid 41416319)
33. F. Matsuura, N. Wang, W. Chen, X.C. Jiang, A.R. Tall, HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway, J. Clin. Invest. 116 (2006) 1435-1442.
34. T.A. Pagler, S. Rhode, A. Neuhofer, H. Laggner, W. Strobl, C. Hinterndorfer, I. Volf, M. Pavelka, E.R. Eckhardt, D.R. van der Westhuyzen, G.J. Schutz, H. Stangl, SR-BImediated high density lipoprotein (HDL) endocytosis leads to HDL resecretion facilitating cholesterol efflux, J. Biol. Chem. 281 (2006) 11193-11204. (Pubitemid 43855545)