메뉴 건너뛰기




Volumn 20, Issue 6, 2013, Pages 677-686

Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss

Author keywords

Micro CT; Osteoporosis; Phytoestrogen; Rat bone; Soy isoflavone

Indexed keywords

GENISTEIN;

EID: 84879188929     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0b013e31827d44df     Document Type: Article
Times cited : (24)

References (69)
  • 1
    • 0000310061 scopus 로고    scopus 로고
    • Genetic organization and transcriptional regulation of rhizobial nodulation genes
    • In: Spaink HP, Kondorosi A, Hooykaas PJJ, eds., the Netherlands: Kluwer Academic Publishers
    • Schlaman HRM, Phillips DA, Kondorosi E. Genetic Organization and Transcriptional Regulation of Rhizobial Nodulation Genes. In: Spaink HP, Kondorosi A, Hooykaas PJJ, eds. The Rhizobiaceae: Molecular Biology of Model Plant-associated Bacteria Dordrecht, the Netherlands: Kluwer Academic Publishers, 1998:361-386.
    • (1998) The Rhizobiaceae: Molecular Biology of Model Plant-associated Bacteria Dordrecht , pp. 361-386
    • Schlaman, H.R.M.1    Phillips, D.A.2    Kondorosi, E.3
  • 3
    • 0025852325 scopus 로고
    • Homology of the ligand-binding regions of Rhizobium symbiotic regulatory protein NodD and vertebrate nuclear receptors
    • Gyorgypal Z, Kondorosi A. Homology of the ligand-binding regions of Rhizobium symbiotic regulatory protein NodD and vertebrate nuclear receptors. Mol Gen Genet 1991;226:337-340.
    • (1991) Mol Gen Genet , vol.226 , pp. 337-340
    • Gyorgypal, Z.1    Kondorosi, A.2
  • 4
    • 65349162111 scopus 로고    scopus 로고
    • Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: Mechanisms of action
    • Dang ZC. Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: Mechanisms of action. Obes Rev 2009;10:342-349.
    • (2009) Obes Rev , vol.10 , pp. 342-349
    • Dang, Z.C.1
  • 5
    • 26944486576 scopus 로고    scopus 로고
    • Molecular effects of the isoflavonoid genistein in prostate cancer
    • Bektic J, Guggenberger R, Eder IE, et al. Molecular effects of the isoflavonoid genistein in prostate cancer. Clin Prostate Cancer 2005;4: 124-129.
    • (2005) Clin Prostate Cancer , vol.4 , pp. 124-129
    • Bektic, J.1    Guggenberger, R.2    Eder, I.E.3
  • 6
    • 2442435876 scopus 로고    scopus 로고
    • Chemical communication threatened by endocrine-disrupting chemicals
    • Fox JE. Chemical communication threatened by endocrine-disrupting chemicals. Environ Health Perspect 2004;112:648-653.
    • (2004) Environ Health Perspect , vol.112 , pp. 648-653
    • Fox, J.E.1
  • 7
    • 33750723146 scopus 로고    scopus 로고
    • Studies of the effects of neonatal exposure to genistein on the developing female reproductive system
    • Jefferson WN, Padilla-Banks E, Newbold RR. Studies of the effects of neonatal exposure to genistein on the developing female reproductive system. J AOAC Int 2006;89:1189-1196.
    • (2006) J AOAC Int , vol.89 , pp. 1189-1196
    • Jefferson, W.N.1    Padilla-Banks, E.2    Newbold, R.R.3
  • 8
    • 0034895785 scopus 로고    scopus 로고
    • Common phytochemicals are ecdysteroid agonists and antagonists: A possible evolutionary link between vertebrate and invertebrate steroid hormones
    • Oberdorster E, Clay MA, Cottam DM, Wilmot FA, McLachlan JA, Milner MJ. Common phytochemicals are ecdysteroid agonists and antagonists: A possible evolutionary link between vertebrate and invertebrate steroid hormones. J Steroid Biochem Mol Biol 2001;77:229-238.
    • (2001) J Steroid Biochem Mol Biol , vol.77 , pp. 229-238
    • Oberdorster, E.1    Clay, M.A.2    Cottam, D.M.3    Wilmot, F.A.4    McLachlan, J.A.5    Milner, M.J.6
  • 9
    • 0014673222 scopus 로고
    • Estrogens in the menopause and postmenopause
    • Rogers J. Estrogens in the menopause and postmenopause. N Engl J Med 1969;280:364-367.
    • (1969) N Engl J Med , vol.280 , pp. 364-367
    • Rogers, J.1
  • 11
    • 84884054821 scopus 로고    scopus 로고
    • Animal models of osteoporosis
    • Marcus R, Feldman D, Nelson DA, Rosen C, eds. Amsterdam, the Netherlands: Elsevier
    • Iwaniec UI, Turner RT. Animal models of osteoporosis. In: Marcus R, Feldman D, Nelson DA, Rosen C, eds. Osteoporosis. Amsterdam, the Netherlands: Elsevier, 2008:985-1110.
    • (2008) Osteoporosis , pp. 985-1110
    • Iwaniec, U.I.1    Turner, R.T.2
  • 12
    • 77649274179 scopus 로고    scopus 로고
    • Impact of dietary genistein and aging on executive function in rats
    • Neese SL, Wang VC, Doerge DR, et al. Impact of dietary genistein and aging on executive function in rats. Neurotoxicol Teratol 2010;32: 200-211.
    • (2010) Neurotoxicol Teratol , vol.32 , pp. 200-211
    • Neese, S.L.1    Wang, V.C.2    Doerge, D.R.3
  • 14
    • 0023488581 scopus 로고
    • Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt AM, Drezner MK, Glorieux FH, et al. Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2:595-610.
    • (1987) J Bone Miner Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3
  • 15
    • 18444365600 scopus 로고    scopus 로고
    • Stereological measures of trabecular bone structure: Comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies
    • Thomsen JS, Laib A, Koller B, Prohaska S, Mosekilde L, Gowin W. Stereological measures of trabecular bone structure: Comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. J Microsc 2005;218:171-179.
    • (2005) J Microsc , vol.218 , pp. 171-179
    • Thomsen, J.S.1    Laib, A.2    Koller, B.3    Prohaska, S.4    Mosekilde, L.5    Gowin, W.6
  • 16
    • 84879188292 scopus 로고    scopus 로고
    • Team RDC. R: A Language And Environment For Statistical Computing. R Foundation For Statistical Computing Vienna Austria. ISBN 3-900051-07-0
    • Team RDC. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, http://www.R-project.org, 2010.
    • (2010)
  • 17
    • 0031663452 scopus 로고    scopus 로고
    • Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako)
    • Watanabe S, Yamaguchi M, Sobue T, et al. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after ingestion of 60 g baked soybean powder (kinako). J Nutr 1998;128:1710-1715.
    • (1998) J Nutr , vol.128 , pp. 1710-1715
    • Watanabe, S.1    Yamaguchi, M.2    Sobue, T.3
  • 18
    • 0029146781 scopus 로고
    • Bioavailability of soybean isoflavones depends upon gut microflora in women
    • Xu X, Harris KS, Wang HJ, Murphy PA, Hendrich S. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 1995;125:2307-2315.
    • (1995) J Nutr , vol.125 , pp. 2307-2315
    • Xu, X.1    Harris, K.S.2    Wang, H.J.3    Murphy, P.A.4    Hendrich, S.5
  • 19
    • 0028838468 scopus 로고
    • Tissue-selective actions of estrogen analogs
    • Evans GL, Turner RT. Tissue-selective actions of estrogen analogs. Bone 1995;17:181S-190S.
    • (1995) Bone , vol.17
    • Evans, G.L.1    Turner, R.T.2
  • 20
    • 0026051934 scopus 로고
    • Dose-dependent effects of tamoxifen on long bones in growing rats influence of ovarian status
    • Moon LY, Wakley GK, Turner RT. Dose-dependent effects of tamoxifen on long bones in growing rats: Influence of ovarian status. Endocrinology 1991;129:1568-1574.
    • (1991) Endocrinology , vol.129 , pp. 1568-1574
    • Moon, L.Y.1    Wakley, G.K.2    Turner, R.T.3
  • 21
    • 0030993372 scopus 로고    scopus 로고
    • Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain
    • Westerlind KC, Wronski TJ, Ritman EL, et al. Estrogen regulates the rate of bone turnover but bone balance in ovariectomized rats is modulated by prevailing mechanical strain. Proc Natl Acad Sci U S A 1997;94: 4199-4204.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4199-4204
    • Westerlind, K.C.1    Wronski, T.J.2    Ritman, E.L.3
  • 23
    • 20844434365 scopus 로고    scopus 로고
    • Weaning initiates a rapid and powerful anabolic phase in the rat maternal skeleton
    • Miller SC, Anderson BL, Bowman BM. Weaning initiates a rapid and powerful anabolic phase in the rat maternal skeleton. Biol Reprod 2005; 73:156-162.
    • (2005) Biol Reprod , vol.73 , pp. 156-162
    • Miller, S.C.1    Anderson, B.L.2    Bowman, B.M.3
  • 24
    • 0031833634 scopus 로고    scopus 로고
    • Comparison of bone loss during normal lactation with estrogen deficiency osteopenia and immobilization osteopenia in the rat
    • Miller SC, Bowman BM. Comparison of bone loss during normal lactation with estrogen deficiency osteopenia and immobilization osteopenia in the rat. Anat Rec 1998;251:265-274.
    • (1998) Anat Rec , vol.251 , pp. 265-274
    • Miller, S.C.1    Bowman, B.M.2
  • 26
    • 33745594281 scopus 로고    scopus 로고
    • Genistein modulates the effects of parathyroid hormone in human osteoblastic SaOS-2 cells
    • Chen WF, Wong MS. Genistein modulates the effects of parathyroid hormone in human osteoblastic SaOS-2 cells. Br J Nutr 2006;95: 1039-1047.
    • (2006) Br J Nutr , vol.95 , pp. 1039-1047
    • Chen, W.F.1    Wong, M.S.2
  • 27
    • 0001680071 scopus 로고    scopus 로고
    • Zinc enhancement of genistein's anabolic effect on bone components in elderly female rats
    • Gao YH, Yamaguchi M. Zinc enhancement of genistein's anabolic effect on bone components in elderly female rats. Gen Pharmacol 1998;31: 199-202.
    • (1998) Gen Pharmacol , vol.31 , pp. 199-202
    • Gao, Y.H.1    Yamaguchi, M.2
  • 28
    • 33750815738 scopus 로고    scopus 로고
    • Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis
    • Yamaguchi M. Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis. Yakugaku Zasshi 2006;126: 1117-1137.
    • (2006) Yakugaku Zasshi , vol.126 , pp. 1117-1137
    • Yamaguchi, M.1
  • 29
    • 64749092257 scopus 로고    scopus 로고
    • The estrogen 17A-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-JB activity
    • Yamaguchi M, Weitzmann MN. The estrogen 17A-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-JB activity. Int J Mol Med 2009;23:297-301.
    • (2009) Int J Mol Med , vol.23 , pp. 297-301
    • Yamaguchi, M.1    Weitzmann, M.N.2
  • 30
    • 0031733298 scopus 로고    scopus 로고
    • Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor A
    • Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor A. Endocrinology 1998;139:4252-4263.
    • (1998) Endocrinology , vol.139 , pp. 4252-4263
    • Kuiper, G.G.1    Lemmen, J.G.2    Carlsson, B.3
  • 31
    • 3242798960 scopus 로고    scopus 로고
    • Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor > (ER>) and ERA in human cells
    • Mueller SO, Simon S, Chae K, Metzler M, Korach KS. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor > (ER>) and ERA in human cells. Toxicol Sci 2004;80:14-25.
    • (2004) Toxicol Sci , vol.80 , pp. 14-25
    • Mueller, S.O.1    Simon, S.2    Chae, K.3    Metzler, M.4    Korach, K.S.5
  • 32
    • 33646811829 scopus 로고    scopus 로고
    • Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function
    • Henley DV, Korach KS. Endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function. Endocrinology 2006;147:S25-S32.
    • (2006) Endocrinology , vol.147
    • Henley, D.V.1    Korach, K.S.2
  • 33
    • 0033039896 scopus 로고    scopus 로고
    • Estrogen has rapid tissue-specific effects on rat bone
    • Turner RT, Kidder LS, Zhang M, et al. Estrogen has rapid tissue-specific effects on rat bone. J Appl Physiol 1999;86:1950-1958.
    • (1999) J Appl Physiol , vol.86 , pp. 1950-1958
    • Turner, R.T.1    Kidder, L.S.2    Zhang, M.3
  • 34
    • 0033789914 scopus 로고    scopus 로고
    • Genistein: Does it prevent or promote breast cancer?
    • Bouker KB, Hilakivi-Clarke L. Genistein: Does it prevent or promote breast cancer? Environ Health Perspect 2000;108:701-708.
    • (2000) Environ Health Perspect , vol.108 , pp. 701-708
    • Bouker, K.B.1    Hilakivi-Clarke, L.2
  • 35
    • 0033190672 scopus 로고    scopus 로고
    • Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring
    • Hilakivi-Clarke L, Cho E, Onojafe I, Raygada M, Clarke R. Maternal exposure to genistein during pregnancy increases carcinogen-induced mammary tumorigenesis in female rat offspring. Oncol Rep 1999;6: 1089-1095.
    • (1999) Oncol Rep , vol.6 , pp. 1089-1095
    • Hilakivi-Clarke, L.1    Cho, E.2    Onojafe, I.3    Raygada, M.4    Clarke, R.5
  • 36
    • 0032774109 scopus 로고    scopus 로고
    • Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis
    • Hilakivi-Clarke L, Onojafe I, Raygada M, et al. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br J Cancer 1999;80:1682-1688.
    • (1999) Br J Cancer , vol.80 , pp. 1682-1688
    • Hilakivi-Clarke, L.1    Onojafe, I.2    Raygada, M.3
  • 37
    • 1542327639 scopus 로고    scopus 로고
    • Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogensensitive organs
    • Murata M, Midorikawa K, Koh M, Umezawa K, Kawanishi S. Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogensensitive organs. Biochemistry 2004;43:2569-2577.
    • (2004) Biochemistry , vol.43 , pp. 2569-2577
    • Murata, M.1    Midorikawa, K.2    Koh, M.3    Umezawa, K.4    Kawanishi, S.5
  • 38
    • 0035360280 scopus 로고    scopus 로고
    • Uterine adenocarcinoma in mice treated neonatally with genistein
    • Newbold RR, Banks EP, Bullock B, Jefferson WN. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 2001;61: 4325-4328.
    • (2001) Cancer Res , vol.61 , pp. 4325-4328
    • Newbold, R.R.1    Banks, E.P.2    Bullock, B.3    Jefferson, W.N.4
  • 39
    • 57349142997 scopus 로고    scopus 로고
    • Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: A follow-up study
    • Marini H, Bitto A, Altavilla D, et al. Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: A follow-up study. J Clin Endocrinol Metab 2008;93:4787-4796.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4787-4796
    • Marini, H.1    Bitto, A.2    Altavilla, D.3
  • 40
    • 33748694688 scopus 로고    scopus 로고
    • Soy protein and bone mineral density in older men and women: A randomized trial
    • Newton KM, LaCroix AZ, Levy L, et al. Soy protein and bone mineral density in older men and women: A randomized trial. Maturitas 2006; 55:270-277.
    • (2006) Maturitas , vol.55 , pp. 270-277
    • Newton, K.M.1    LaCroix, A.Z.2    Levy, L.3
  • 41
    • 70349918167 scopus 로고    scopus 로고
    • Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology
    • Weaver CM, Martin BR, Jackson GS, et al. Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology. J Clin Endocrinol Metab 2009;94:3798-3805.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3798-3805
    • Weaver, C.M.1    Martin, B.R.2    Jackson, G.S.3
  • 42
    • 77956360497 scopus 로고    scopus 로고
    • Soy isoflavones and bone mineral density in perimenopausal and postmenopausal Western women: A systematic review and meta-analysis of randomized controlled trials
    • Ricci E, Cipriani S, Chiaffarino F, Malvezzi M, Parazzini F. Soy isoflavones and bone mineral density in perimenopausal and postmenopausal Western women: A systematic review and meta-analysis of randomized controlled trials. J Womens Health (Larchmt) 2010;19: 1609-1617.
    • (2010) J Womens Health (Larchmt) , vol.19 , pp. 1609-1617
    • Ricci, E.1    Cipriani, S.2    Chiaffarino, F.3    Malvezzi, M.4    Parazzini, F.5
  • 43
    • 80051628660 scopus 로고    scopus 로고
    • Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: A randomized, double-blind trial
    • Levis S, Strickman-Stein N, Ganjei-Azar P, Xu P, Doerge DR, Krischer J. Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: A randomized, double-blind trial. Arch Intern Med 2011;171:1363-1369.
    • (2011) Arch Intern Med , vol.171 , pp. 1363-1369
    • Levis, S.1    Strickman-Stein, N.2    Ganjei-Azar, P.3    Xu, P.4    Doerge, D.R.5    Krischer, J.6
  • 44
    • 80051609355 scopus 로고    scopus 로고
    • Soy isoflavones for prevention of menopausal bone loss and vasomotor symptoms: Comment on Bsoy isoflavones in the prevention of menopausal bone loss and menopausal symptoms
    • Newton KM, Grady D. Soy isoflavones for prevention of menopausal bone loss and vasomotor symptoms: Comment on Bsoy isoflavones in the prevention of menopausal bone loss and menopausal symptoms[. Arch Intern Med 2011;171:1369-1370.
    • (2011) Arch Intern Med , vol.171 , pp. 1369-1370
    • Newton, K.M.1    Grady, D.2
  • 45
    • 16244415540 scopus 로고    scopus 로고
    • Dietary soy protein and isoflavones: Minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats
    • Bahr JM, Nakai M, Rivera A, et al. Dietary soy protein and isoflavones: Minimal beneficial effects on bone and no effect on the reproductive tract of sexually mature ovariectomized Sprague-Dawley rats. Menopause 2005;12:165-173.
    • (2005) Menopause , vol.12 , pp. 165-173
    • Bahr, J.M.1    Nakai, M.2    Rivera, A.3
  • 46
    • 0031698560 scopus 로고    scopus 로고
    • The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats
    • Fanti P, Monier-Faugere MC, Geng Z, et al. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos Int 1998;8:274-281.
    • (1998) Osteoporos Int , vol.8 , pp. 274-281
    • Fanti, P.1    Monier-Faugere, M.C.2    Geng, Z.3
  • 47
    • 25444482167 scopus 로고    scopus 로고
    • Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: Effects on bone, uterus, and lipid profile
    • Gallo D, Zannoni GF, Apollonio P, et al. Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: Effects on bone, uterus, and lipid profile. Menopause 2005;12:589-600.
    • (2005) Menopause , vol.12 , pp. 589-600
    • Gallo, D.1    Zannoni, G.F.2    Apollonio, P.3
  • 48
    • 58649096568 scopus 로고    scopus 로고
    • Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats
    • Hertrampf T, Schleipen B, Offermanns C, Velders M, Laudenbach U, Diel P. Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats. Toxicol Lett 2009;184:198-203.
    • (2009) Toxicol Lett , vol.184 , pp. 198-203
    • Hertrampf, T.1    Schleipen, B.2    Offermanns, C.3    Velders, M.4    Laudenbach, U.5    Diel, P.6
  • 49
    • 16244392961 scopus 로고    scopus 로고
    • Dietary soy protein and isoflavones have no significant effect on bone and a potentially negative effect on the uterus of sexually mature intact Sprague-Dawley female rats
    • Nakai M, Cook L, Pyter LM, et al. Dietary soy protein and isoflavones have no significant effect on bone and a potentially negative effect on the uterus of sexually mature intact Sprague-Dawley female rats. Menopause 2005;12:291-298.
    • (2005) Menopause , vol.12 , pp. 291-298
    • Nakai, M.1    Cook, L.2    Pyter, L.M.3
  • 50
    • 77953881925 scopus 로고    scopus 로고
    • Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model
    • Sehmisch S, Erren M, Kolios L, et al. Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model. Phytother Res 2010;24:S168-S174.
    • (2010) Phytother Res , vol.24
    • Sehmisch, S.1    Erren, M.2    Kolios, L.3
  • 51
    • 0034913405 scopus 로고    scopus 로고
    • Tissue-selective effects of continuous release of 2-hydroxyestrone and 16>-hydroxyestrone on bone, uterus and mammary gland in ovariectomized growing rats
    • Lotinun S, Westerlind KC, Turner RT. Tissue-selective effects of continuous release of 2-hydroxyestrone and 16>-hydroxyestrone on bone, uterus and mammary gland in ovariectomized growing rats. J Endocrinol 2001;170:165-174.
    • (2001) J Endocrinol , vol.170 , pp. 165-174
    • Lotinun, S.1    Westerlind, K.C.2    Turner, R.T.3
  • 52
    • 0031746357 scopus 로고    scopus 로고
    • Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats
    • Westerlind KC, Gibson KJ, Malone P, Evans GL, Turner RT. Differential effects of estrogen metabolites on bone and reproductive tissues of ovariectomized rats. J Bone Miner Res 1998;13:1023-1031.
    • (1998) J Bone Miner Res , vol.13 , pp. 1023-1031
    • Westerlind, K.C.1    Gibson, K.J.2    Malone, P.3    Evans, G.L.4    Turner, R.T.5
  • 53
    • 33746750879 scopus 로고    scopus 로고
    • Effects of stable transfection of human fetal osteoblast cells with estrogen receptor-> on regulation of gene expression by tibolone
    • Maran A, Shogren K, Zhang M, et al. Effects of stable transfection of human fetal osteoblast cells with estrogen receptor-> on regulation of gene expression by tibolone. Bone 2006;39:523-529.
    • (2006) Bone , vol.39 , pp. 523-529
    • Maran, A.1    Shogren, K.2    Zhang, M.3
  • 54
    • 33846333540 scopus 로고    scopus 로고
    • Postmenopausal tibolone therapy: Biologic principles and applied clinical practice
    • Notelovitz M. Postmenopausal tibolone therapy: Biologic principles and applied clinical practice. MedGenMed 2007;9:2.
    • (2007) MedGenMed , vol.9 , pp. 2
    • Notelovitz, M.1
  • 55
    • 0025125950 scopus 로고
    • Estrogen inhibition of periosteal bone formation in rat long bones: Down-regulation of gene expression for bone matrix proteins
    • Turner RT, Colvard DS, Spelsberg TC. Estrogen inhibition of periosteal bone formation in rat long bones: Down-regulation of gene expression for bone matrix proteins. Endocrinology 1990;127:1346-1351.
    • (1990) Endocrinology , vol.127 , pp. 1346-1351
    • Turner, R.T.1    Colvard, D.S.2    Spelsberg, T.C.3
  • 56
    • 0027400961 scopus 로고
    • Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: Inhibition of indices of formation and resorption
    • Turner RT, Evans GL, Wakley GK. Mechanism of action of estrogen on cancellous bone balance in tibiae of ovariectomized growing rats: Inhibition of indices of formation and resorption. J Bone Miner Res 1993;8:359-366.
    • (1993) J Bone Miner Res , vol.8 , pp. 359-366
    • Turner, R.T.1    Evans, G.L.2    Wakley, G.K.3
  • 57
    • 0021988032 scopus 로고
    • Opposing biological actions of antiestrogens in vitro and in vivo: Induction of progesterone receptor in the rat and mouse uterus
    • Campen CA, Jordan VC, Gorski J. Opposing biological actions of antiestrogens in vitro and in vivo: Induction of progesterone receptor in the rat and mouse uterus. Endocrinology 1985;116:2327-2336.
    • (1985) Endocrinology , vol.116 , pp. 2327-2336
    • Campen, C.A.1    Jordan, V.C.2    Gorski, J.3
  • 58
    • 0021889085 scopus 로고
    • Metabolism of tamoxifen and its uterotrophic activity
    • Lyman SD, Jordan VC. Metabolism of tamoxifen and its uterotrophic activity. Biochem Pharmacol 1985;34:2787-2794.
    • (1985) Biochem Pharmacol , vol.34 , pp. 2787-2794
    • Lyman, S.D.1    Jordan, V.C.2
  • 59
    • 0006981987 scopus 로고
    • Species differences in the reaction of the mammalian skeleton to estrogens
    • Urist MR, Budy AM, McLean FC. Species differences in the reaction of the mammalian skeleton to estrogens. Proc Soc Exp Biol Med 1948;68: 324-326.
    • (1948) Proc Soc Exp Biol Med , vol.68 , pp. 324-326
    • Urist, M.R.1    Budy, A.M.2    McLean, F.C.3
  • 60
  • 61
    • 77949710225 scopus 로고    scopus 로고
    • Neonatal administration of isoflavones attenuates deterioration of bone tissue in female but not male mice
    • Kaludjerovic J, Ward WE. Neonatal administration of isoflavones attenuates deterioration of bone tissue in female but not male mice. J Nutr 2010;140:766-772.
    • (2010) J Nutr , vol.140 , pp. 766-772
    • Kaludjerovic, J.1    Ward, W.E.2
  • 62
    • 34547415141 scopus 로고    scopus 로고
    • Soy isoflavones and fatty acids: Effects on bone tissue postovariectomy in mice
    • Ward WE, Fonseca D. Soy isoflavones and fatty acids: Effects on bone tissue postovariectomy in mice. Mol Nutr Food Res 2007;51:824-831.
    • (2007) Mol Nutr Food Res , vol.51 , pp. 824-831
    • Ward, W.E.1    Fonseca, D.2
  • 64
    • 80051546618 scopus 로고    scopus 로고
    • Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats
    • Jackson MA, Iwaniec UT, Turner RT, Wronski TJ, Kalra SP. Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats. Peptides 2011;32:1575-1580.
    • (2011) Peptides , vol.32 , pp. 1575-1580
    • Jackson, M.A.1    Iwaniec, U.T.2    Turner, R.T.3    Wronski, T.J.4    Kalra, S.P.5
  • 67
    • 0034829143 scopus 로고    scopus 로고
    • Effects of soy phytoestrogens genistein and daidzein on breast cancer growth
    • de Lemos ML. Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann Pharmacother 2001;35:1118-1121.
    • (2001) Ann Pharmacother , vol.35 , pp. 1118-1121
    • De Lemos, M.L.1
  • 68
    • 77956283422 scopus 로고    scopus 로고
    • Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling
    • Henley DV, Korach KS. Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones (Athens) 2010;9:191-205.
    • (2010) Hormones (Athens) , vol.9 , pp. 191-205
    • Henley, D.V.1    Korach, K.S.2
  • 69
    • 79953756068 scopus 로고    scopus 로고
    • Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes
    • Jefferson WN, Williams CJ. Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes. Reprod Toxicol 2011;31:272-279.
    • (2011) Reprod Toxicol , vol.31 , pp. 272-279
    • Jefferson, W.N.1    Williams, C.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.