Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Faller, Kiterie M E ^a   Medway, Debra J ^a   Aksentijevic, Dunja ^a   Sebag Montefiore, Liam ^a   Schneider, Jürgen E ^a   Lygate, Craig A ^a   Neubauer, Stefan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; CARRIER PROTEIN; CREATINE; CREATINE TRANSPORTER; RIBOSE; RIBOSE 5 PHOSPHATE; UNCLASSIFIED DRUG; CREATININE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; IN VIVO STUDY; MOUSE; NONHUMAN; PILOT STUDY; SUPPLEMENTATION; ANIMAL; CARDIAC MUSCLE; HEART FUNCTION TEST; METABOLISM; PATHOPHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ADENINE NUCLEOTIDES; ANIMALS; CREATININE; HEART FAILURE; HEART FUNCTION TESTS; MICE; MICE, TRANSGENIC; MYOCARDIUM; PILOT PROJECTS; RIBOSE;

EID: 84879170241     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066461     Document Type: Article

References (32)

1. Neubauer S, (2007) The failing heart-an engine out of fuel. New Engl J Med 356: 1140-1151.
2. Ingwall JS, Weiss RG, (2004) Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95: 135-145.
3. Shen W, Asai K, Uechi M, Mathier MA, Shannon RP, et al. (1999) Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine. Circulation 100: 2113-2118.
4. Ingwall JS, (2009) Energy metabolism in heart failure and remodelling. Cardiovasc Res 81: 412-419.
5. Hunsucker SA, Mitchell BS, Spychala J, (2005) The 5′-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther 107: 1-30.
6. Zimmer HG, Trendelenburg C, Kammermeier H, Gerlach E, (1973) De novo synthesis of myocardial adenine nucleotides in the rat. Acceleration during recovery from oxygen deficiency. Circ Res 32: 635-642.
7. Sonoda T, Ishizuka T, Ishijima S, Kita K, Ahmad I, et al. (1998) Rat liver phosphoribosylpyrophosphate synthetase is activated by free Mg2+ in a manner that overcomes its inhibition by nucleotides. Biochim Biophys Acta 1387: 32-40.
8. Kim YA, King MT, Teague WE Jr, Rufo GA Jr, Veech RL, et al. (1992) Regulation of the purine salvage pathway in rat liver. Am J Physiol Endocrinol Metabol 262: E344-352.
9. Starling RC, Hammer DF, Altschuld RA, (1998) Human myocardial ATP content and in vivo contractile function. Mol Cell Biochem 180: 171-177.
10. Lamberts RR, Caldenhoven E, Lansink M, Witte G, Vaessen RJ, et al. (2007) Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats. Am J Physiol: Heart Circ Physiol 293: H1869-1876.
11. Pliml W, von Arnim T, Stablein A, Hofmann H, Zimmer HG, et al. (1992) Effects of ribose on exercise-induced ischaemia in stable coronary artery disease. Lancet 340: 507-510.
12. Zimmer HG, (1983) Normalization of depressed heart function in rats by ribose. Science 220: 81-82.
13. Zimmer HG, Ibel H, Steinkopff G, Korb G, (1980) Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose. Science 207: 319-321.
14. Zimmer HG, Ibel H, (1984) Ribose accelerates the repletion of the ATP pool during recovery from reversible ischemia of the rat myocardium. J Mol Cell Cardiol 16: 863-866.
15. Zimmer HG, Martius PA, Marschner G, (1989) Myocardial infarction in rats: effects of metabolic and pharmacologic interventions. Basic Res Cardiol 84: 332-343.
16. St Cyr JA, Bianco RW, Schneider JR, Mahoney JR Jr, Tveter K, et al. (1989) Enhanced high energy phosphate recovery with ribose infusion after global myocardial ischemia in a canine model. J Surg Res 46: 157-162.
17. Mauser M, Hoffmeister HM, Nienaber C, Schaper W, (1985) Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog. Circ Res 56: 220-230.
18. Omran H, Illien S, MacCarter D, St Cyr J, Luderitz B, (2003) D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study. Eur J Heart Fail 5: 615-619.
19. Perkowski D, Wagner S, St Cyr JA, (2007) D-ribose benefits "off" pump coronary artery bypass revascularization. J Card Surg 22: 370-371.
20. Sawada SG, Lewis S, Kovacs R, Khouri S, Gradus-Pizlo I, et al. (2009) Evaluation of the anti-ischemic effects of D-ribose during dobutamine stress echocardiography: a pilot study. Cardiovasc Ultrasound 7: 5.
21. MacCarter D, Vijay N, Washam M, Shecterle L, Sierminski H, et al. (2009) D-ribose aids advanced ischemic heart failure patients. Int J Cardiol 137: 79-80.
22. Caretti A, Bianciardi P, Sala G, Terruzzi C, Lucchina F, et al. (2010) Supplementation of creatine and ribose prevents apoptosis in ischemic cardiomyocytes. Cell Physiol Biochem 26: 831-838.
23. Lygate CA, Bohl S, Ten Hove M, Faller KM, Ostrowski PJ, et al. (2012) Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res 96: 466-475.
24. Wu F, Zhang J, Beard DA, (2009) Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl Acad Sci USA 106: 7143-7148.
25. Wallis J, Lygate CA, Fischer A, ten Hove M, Schneider JE, et al. (2005) Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice. Circulation 112: 3131-3139.
26. Neubauer S, Horn M, Naumann A, Tian R, Hu K, et al. (1995) Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest 95: 1092-1100.
27. Lygate C, (2006) Surgical models of hypertrophy and heart failure: Myocardial infarction and transverse aortic constriction. Drug Disc Today Dis Models 3: 283-290.
28. ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, et al. (2005) Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 111: 2477-2485.
29. Schneider JE, Tyler DJ, ten Hove M, Sang AE, Cassidy PJ, et al. (2004) In vivo cardiac 1H-MRS in the mouse. Magn Reson Med 52: 1029-1035.
30. King MT, Passonneau JV, Veech RL, (1990) Radiometric measurement of phosphoribosylpyrophosphate and ribose 5-phosphate by enzymatic procedures. Anal Biochem 187: 179-186.
31. Lygate CA, Fischer A, Sebag-Montefiore L, Wallis J, Ten Hove M, et al. (2007) The creatine kinase energy transport system in the failing mouse heart. J Mol Cell Cardiol 42: 1129-1136.
32. Lortet S, Zimmer HG, (1989) Functional and metabolic effects of ribose in combination with prazosin, verapamil and metoprolol in rats in vivo. Cardiovasc Res 23: 702-708.