APC/CCdh1-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle

Biochemical and Biophysical Research Communications

Volumn 436, Issue 1, 2013, Pages 12-18

  Hyun, Sun Yi ^a   Sarantuya, Badmaarag ^a   Lee, Hee Jae ^a   Jang, Young Joo ^a  

^a Dankook University   (South Korea)

Author keywords

APC CCdh1; Cdc20; CRY box; Degron; Phosphorylation; Plk1

Indexed keywords

ALANINE; ANAPHASE PROMOTING COMPLEX; CELL CYCLE PROTEIN 20; POLO LIKE KINASE 1; SERINE; UVOMORULIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CENTROMERE; CENTROSOME; HELA CELL; MITOSIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SOMATIC CELL; SPINDLE CELL; UBIQUITINATION;

CADHERINS; CELL CYCLE; CELL CYCLE PROTEINS; G1 PHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MITOSIS; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; UBIQUITIN;

MAMMALIA;

EID: 84879164793     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.073     Document Type: Article

References (29)

1. Ohkura H., Hagan I.M., Glover D.M. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev. 1995, 9:1059-1073.
2. Lane H.A., Nigg E.A. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J. Cell Biol. 1996, 135:1701-1713.
3. Sunkel C.E., Glover D.M. Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J. Cell Sci. 1988, 89(Pt. 1):25-38.
4. Descombes P., Nigg E.A. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J. 1998, 17:1328-1335.
5. May K.M., Reynolds N., Cullen C.F., Yanagida M., Ohkura H. Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis. J. Cell Biol. 2002, 156:23-28.
6. Shirayama M., Zachariae W., Ciosk R., Nasmyth K. The polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J. 1998, 17:1336-1349.
7. Logarinho E., Sunkel C.E. The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes. J. Cell Sci. 1998, 111(Pt. 19):2897-2909.
8. Arnaud L., Pines J., Nigg E.A. GFP tagging reveals human polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes. Chromosoma 1998, 107:424-429.
9. Ji J.H., Jang Y.J. Screening of domain-specific target proteins of polo-like kinase 1: construction and application of centrosome/kinetochore-specific targeting peptide. J. Biochem. Mol. Biol. 2006, 39:709-716.
10. Peters J.M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 2006, 7:644-656.
11. Yu H. Cdc20: a WD40 activator for a cell cycle degradation machine. Mol. Cell 2007, 27:3-16.
12. Fang G., Yu H., Kirschner M.W. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 1998, 2:163-171.
13. Pfleger C.M., Kirschner M.W. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 2000, 14:655-665.
14. Reis A., Levasseur M., Chang H.Y., Elliott D.J., Jones K.T. The CRY box: a second APCcdh1-dependent degron in mammalian cdc20. EMBO Rep. 2006, 7:1040-1045.
15. Jang Y.J., Ma S., Terada Y., Erikson R.L. Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase. J. Biol. Chem. 2002, 277:44115-44120.
16. Jang Y.J., Lin C.Y., Ma S., Erikson R.L. Functional studies on the role of the C-terminal domain of mammalian polo-like kinase. Proc. Natl. Acad. Sci. USA 2002, 99:1984-1989.
17. Lee K.S., Erikson R.L. Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures. Mol. Cell. Biol. 1997, 17:3408-3417.
18. Vodermaier H.C. Cell cycle: waiters serving the destruction machinery. Curr. Biol. 2001, 11:R834-R837.
19. Chung E., Chen R.H. Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint. Nat. Cell Biol. 2003, 5:748-753.
20. D'Angiolella V., Mari C., Nocera D., Rametti L., Grieco D. The spindle checkpoint requires cyclin-dependent kinase activity. Genes Dev. 2003, 17:2520-2525.
21. Gorr I.H., Boos D., Stemmann O. Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol. Cell 2005, 19:135-141.
22. Zur A., Brandeis M. Timing of APC/C substrate degradation is determined by fzy/fzr specificity of destruction boxes. EMBO J. 2002, 21:4500-4510.
23. Hagting A., Den Elzen N., Vodermaier H.C., Waizenegger I.C., Peters J.M., Pines J. Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 2002, 157:1125-1137.
24. Nakajima H., Toyoshima-Morimoto F., Taniguchi E., Nishida E. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J. Biol. Chem. 2003, 278:25277-25280.
25. Erikson E., Haystead T.A., Qian Y.W., Maller J.L. A feedback loop in the polo-like kinase activation pathway. J. Biol. Chem. 2004, 279:32219-32224.
26. Hwang H.I., Ji J.H., Jang Y.J. Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression. J. Biol. Chem. 2011, 286:33012-33020.
27. Hansen D.V., Loktev A.V., Ban K.H., Jackson P.K. Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor emi1. Mol. Biol. Cell 2004, 15:5623-5634.
28. Searle J.S., Schollaert K.L., Wilkins B.J., Sanchez Y. The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat. Cell Biol. 2004, 6:138-145.
29. Tang Z., Shu H., Oncel D., Chen S., Yu H. Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol. Cell 2004, 16:387-397.