Prevalence, risk factors and outcome of hyperlactataemia in HIV-infected patients

HIV Medicine

Volumn 4, Issue 1, 2003, Pages 18-23

  Hocqueloux, L ^a,b   Alberti, C ^a   Feugeas, J P ^a   Lafaurie, M ^a   Lukasiewicz, E ^a   Bagnard, G ^a   Carel, O ^a   Erlich, D ^a   Molina, Jean Michel ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b CENTRE HOSPITALIER RÉGIONAL D ORLÉANS   (France)

Author keywords

Hyperlactataemia; Nucleoside analogue reverse transcriptase inhibitors

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIRETROVIRUS AGENT; CARNITINE; DIDANOSINE; EFAVIRENZ; HYDROXYUREA; INDINAVIR; LACTIC ACID; LAMIVUDINE; NEVIRAPINE; PROTEINASE INHIBITOR; RIBOFLAVIN; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; ZALCITABINE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DEATH; DEMOGRAPHY; DISEASE COURSE; DRUG INDUCED DISEASE; DRUG USE; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEPATORENAL SYNDROME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERLACTATEMIA; IMMUNITY; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LIPOATROPHY; MALE; MORTALITY; PANCREATITIS; PERIPHERAL NEUROPATHY; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL ANALYSIS; SYMPTOM; VIROLOGY; BLOOD; CHEMICALLY INDUCED DISORDER; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDY;

ACIDOSIS, LACTIC; ADULT; ANTI-HIV AGENTS; DIDANOSINE; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; PREVALENCE; PROGNOSIS; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE INHIBITORS; RISK FACTORS; STAVUDINE;

EID: 0037271903     PISSN: 14642662     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-1293.2003.00132.x     Document Type: Article

References (25)

1. Brinkman K. Management of hyperlactatemia: no need for routine lactate measurements. AIDS 2001; 15: 795-797.
2. Brinkman K, ter Hofstede HJM, Burger DM, Smeitink JAM, Koopmans PP. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS 1998; 12: 1735-1744.
3. Boubaker K, Flepp M, Sudre P et al. Hyperlactatemia and antiretroviral therapy: the Swiss HIV Cohort Study. Clin Infect Dis 2001; 33: 1931-1937.
4. Lonergan JT, Havlir D, Barber E, Mathews WC. Incidence of symptomatic hyperlactatemia in HIV-infected adults on NRTIs. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, WA, February 2002 [Abstract A35].
5. Greenberg RN, Rapp D, Thornton AC. Elevation of plasma lactic acid in HIV patients receiving nucleoside reverse transcriptase inhibitors. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada, September 2000 [Abstract 1300].
6. McCalister S, Alonso MC. Clinical, virologic, and immunologic significance of lactic acid levels in HIV+ adults. 40th Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Canada, September 2000 [Abstract 1301].
7. Harris M, Tesiorowski A, Montaner JSG. Screening for nucleoside-associated lactic acidosis. XIII International AIDS Conference. Durban, South Africa, July 2000 [Abstract TuPpB1233].
8. Brinkman K, Troost N, Schrijnders L et al. Usefulness of routine lactate measurement to prevent lactic acidosis: evaluation of a protocol. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, WA, February 2002 [Abstract A709T].
9. Chattha G, Arieff AI, Cummings C, Tierney LM Jr. Lactic acidosis complicating the acquired immunodeficiency syndrome. Ann Intern Med 1993; 118: 37-39.
10. Bissuel F, Bruneel F, Habersetzer F et al. Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy. J Intern Med 1994; 235: 367-372.
11. Sundar K, Suarez M, Banogon PE, Shapiro JM. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome report of two patients and review of the literature. Crit Care Med 1997; 25: 1425-1430.
12. Lai KK, Gang DL, Zawacki JY, Cooley TP. Fulminant hepatic failure associated with 2′,3′-dideoxyinosine (ddI). Ann Intern Med 1991; 115: 283-284.
13. Gérard Y, Maulin L, Yazdanpanah Y et al. Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy. AIDS 2000; 14: 2723-2730.
14. Lonergan JT, Behling C, Pfander H, Hassanein TI, Mathews WC. Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens. Clin Infect Dis 2000; 31: 162-166.
15. Johri S, Alkhuja S, Siviglia G, Soni A. Steatosis-lactic acidosis syndrome associated with stavudine and lamivudine therapy. AIDS 2000; 14: 1286-1287.
16. Brinkman K, Vrouenraets S, Kauffmann R, Weigel H, Frissen J. Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis. AIDS 2000; 14: 2801-2802.
17. Lonergan JT, Havlir D, Behling C, Pfander H, Hassanein T, Mathews WC. Hyperlactatemia in 20 patients receiving NRTI combination regimens. 7th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA, January-February 2000 [Abstract 56].
18. Ter Hofstede H, De Marie S, Foudraine N, Danner S, Brinkman K. Four cases of fatal lactic acidosis due to mitochondrial toxicity of NRTI treatment: analysis of clinical features and risk factors. 7th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA, January-February 2000 [Abstract 59].
19. John M, Moore CB, James IR et al. Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy. AIDS 2001; 15: 717-723.
20. Falco V, Rodriguez D, Ribera E et al. Severe nucleoside-associated lactic acidosis in human immunodeficiency virus-infected patients: report of 12 cases and review of the literature. Clin Infect Dis 2002; 34: 838-846.
21. Coghlan ME, Sommadossi JP, Jhala NC, Many WJ, Saag MS, Johnson VA. Symptomatic lactic acidosis in hospitalized antiretroviral-treated patients with human immunodeficiency virus infection a report of 12 cases. Clin Infect Dis 2001; 33: 1914-1921.
22. Delgado J, Harris M, Tesiorowski A, Montaner JSG. Symptomatic elevations of lactic acid and their response to treatment manipulation in human immunodeficiency virus-infected persons: a case series. Clin Infect Dis 2001; 33: 2072-2074.
23. Carr A, Miller J, Law M, Cooper DA. A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 2000; 14: F25-F32.
24. Fortgang IS, Belitsos PC, Chaisson RE, Moore RD. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy. Am J Gastroenterol 1995; 90: 1433-1436.
25. Claessens YE, Cariou A, Chiche JD, Dauriat G, Dhainaut JF. L-Carnitine as a treatment of life-threatening lactic acidosis induced by nucleoside analogues. AIDS 2000; 14: 472-473.