Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population

Pathologie Biologie

Volumn 61, Issue 3, 2013, Pages 113-116

  Trad, B ^a   Ben Hassine, H ^b   Khalifa, M ^a   Idriss, N ^b   Slama, F ^b   Bahri, F ^a   Laouani kechrid, C ^c   Boukadida, J ^a   Sghiri, R ^a  

^a FARHAT HACHED HOSPITAL   (Tunisia)

^b UNIVERSITY OF SOUSSE   (Tunisia)

^c SAHLOUL UNIVERSITY HOSPITAL   (Tunisia)

Author keywords

Anti C1q autoantibodies; Nephritis; Renal biopsy; SLEDAI index; Systemic lupus erythematosus

Indexed keywords

COMPLEMENT COMPONENT C1Q ANTIBODY; COMPLEMENT COMPONENT C4; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; NUCLEOSOME ANTIBODY; SM ANTIBODY;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE DISEASE; CARDIOVASCULAR DISEASE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GASTROINTESTINAL DISEASE; HEMATOLOGIC DISEASE; HEMATURIA; HUMAN; HYPERTENSION; KIDNEY DISEASE; KIDNEY FAILURE; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEPHRITIS; NEPHROTIC SYNDROME; PRESCHOOL CHILD; PREVALENCE; PROTEINURIA; RETROSPECTIVE STUDY; RHEUMATOID ARTHRITIS; SCHOOL CHILD; SKIN DISEASE; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; ADULT; AGED; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; COMPLEMENT C1Q; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; POPULATION; RETROSPECTIVE STUDIES; SEROEPIDEMIOLOGIC STUDIES; TUNISIA; YOUNG ADULT;

EID: 84879153703     PISSN: 03698114     EISSN: 17683114     Source Type: Journal    
DOI: 10.1016/j.patbio.2013.01.007     Document Type: Article

References (30)

1. Lipsky P.E. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol 2001, 2:764-766.
2. Trouw L.A., Roos A., Daha M.R. Autoantibodies to complement components. Mol Immunol 2001, 38:199-206.
3. Uwatoko S., Aotsuka S., Okawa M., Egusa Y., Yokohari R., Aizawa C., et al. Characterization of C1q-binding IgG complexes in systemic lupus erythematosus. Clin Immunol Immunopathol 1984, 30:104-116.
4. Uwatoko S., Mannik M. Low-molecular wight C1q binding immunoglobulin G in patients with systemic lupus erythematosus consists of autoantibodies to the collagen-like region of C1q. J Clin Invest 1988, 82:816-824.
5. Davies K.A., Robson M.G., Peters A.M., Norsworthy P., Nash J.T., Walport M.J. Defective Fc-dependent processing of immune complexes in patients with systemic lupus erythematosus. Arthritis Rheum 2002, 46:1028-1038.
6. Walport M.J. Complement and systemic lupus erythematosus. Arthritis Res 2002, 4(Suppl. 3):S279-S293.
7. Charles P.J. Defective waste disposal: does it induce autoantibodies in SLE?. Ann Rheum Dis 2003, 62:1-3.
8. Taylor P.R. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 2000, 192:359-366.
9. Mevorach D., Zhou J.L., Song X., Elkon K.B. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med 1998, 188:387-392.
10. Tan E.M., Cohen A.S., Fries J.F., Masi A.T., McShane D.J., Rothfield N.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982, 25:1271-1277.
11. Weening J.J., D'Agati V.D., Schwartz M.M., Seshan S.V., Alpers C.E., Appel G.B., et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 2004, 65:521-530.
12. Seelen M.A., Trouw L.A., Daha M.R. Diagnostic and pronostic significance of anti-C1q antibodies in systemic lupus erythematosus. Curr Opin Nephrol Hypertens 2003, 12:619-624.
13. Sinico R.A., Radice A., Ikehata M., Giammarresi G., Corace C., Arrigo G., et al. Anti-C1q autoantibodies in lupus nephrithis prevalence and clinical significance. Ann N Y Acad Sci 2005, 105:193-200.
14. Siegert C.E., Daha M.R., Halma C., van der Voort E.A., Breedveld F.C. Ig A auto-antibodies to C1q in systemic and renal diseases. Clin Exp Rheumatol 1992, 10:19-23.
15. Schifferli J.A., Sadallah S., Gasser O. Autoantibodies anti-C1q during systemic lupus erythematosus. Actualités néphrologiques 2003, Flammarion médecine-sciences, Paris.
16. Reveille J.D. Predictive value of autoantibodies for activity of systemic lupus erythematosus. Lupus 2004, 13:290-297.
17. Mårtensson U., Thiel S., Jensenius J.C., Sjöholm A.G. Human autoantibodies against C1q: lack of cross reactivity with the collectins mannan-binding protein, lung surfactant protein A and bovine conglutinin. Scand J Immunol 1996, 43:314-320.
18. Flierman R., Daha M.R. Pathogenic role of anti-C1q autoantibodies in the development of lupus nephritis - a hypothesis. Mol Immunol 2007, 44:133-138.
19. Houssiau F.A., Vasconcelos C., D'Cruz D., Sebastiani G.D., de Ramon Garrido E., Danieli M.G., et al. Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial. Arthritis Rheum 2004, 50:3934-3940.
20. Yee C.S., Hussein H., Skan J. Association of damage with autoantibody profile, age, sex and disease duration in systemic lupus erythematosus. Rheumatology (Oxford) 2003, 42:276-279.
21. Alba P., Bento L., Cuadrado M.J., Karim Y., Tungekar M.F., Abbs I., et al. Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis. Ann Rheum Dis 2003, 62:556-560.
22. Siegert C.E., Daha M.R., Tseng C.M., Coremans I.E., van Es L.A., Breedveld F.C. Predictive value of IgG autoantibodies against C1q for nephritis in systemic lupus erythematosus. Ann Rheum Dis 1993, 52:851-856.
23. Coremans I.E., Spronk P.E., Bootsma H., Daha M.R., van der Voort E.A., Kater L., et al. Changes in antibodies to C1q predict renal relapses in systemic lupus erythematosus. Am J Kidney Dis 1995, 26:595-601.
24. Meyer O.C., Nicaise-Roland P., Cadoudal N., Grootenboer-Mignot S., Palazzo E., Hayem G., et al. Anti-C1q antibodies antedate patent active glomerulonephritis in patients with systemic lupus erythematosus. Arthritis Res Ther 2009, 11(3):R87.
25. Marto N., Bertolaccini M.L., Calabuig E., Hughes G.R., Khamashta M.A. Anti-C1q antibodies in nephritis: correlation between titres and renal diseases activity and positive predictive value in systemic lupus erythematosus. Ann Rheum Dis 2005, 64:444-448.
26. Horák P., Hermanová Z., Zadrazil J., Ciferská H., Ordeltová M., Kusá L., et al. C1q complement component and -antibodies reflect SLE activity and kidney involvement. Clin Rheumatol 2006, 25:532-536.
27. Trendelenburg M., Lopez-Trascasa M., Potlukova E. High prevalence of anti-C1q antibodies in biopsy-proven active lupus nephritis. Nephrol Dial Transplant 2006, 21:3115-3121.
28. Gunnarsson I., Sundelin B., Heimbürger M., Forslid J., van Vollenhoven R., Lundberg I., et al. Repeated renal biopsy in proliferative lupus nephritis-predictive role of serum C1q and albuminuria. J Rheumatol 2002, 29:693-699.
29. Katsumata Y., Miyake K., Kawaguchi Y., Okamoto Y., Kawamoto M., Gono T., et al. Anti-C1q antibodies are associated with systemic lupus erythematosus global activity, but not specifically with nephritis: a controlled study of 126 consecutive patients. Arthritis Rheum 2011, 63:2436-2444.
30. Bigler C., Hopfer H., Danner D., Schaller M., Mihatsch M.J., Trendelenburg M. Anti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis. Nephrol Dial Transplant 2011, 26:1220-1228.