Anti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis

Nephrology Dialysis Transplantation

Volumn 26, Issue 4, 2011, Pages 1220-1228

  Bigler, Cornelia ^a   Hopfer, Helmut ^a   Danner, Doris ^a   Schaller, Monica ^a   Mihatsch, Michael J ^a   Trendelenburg, Marten ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

autoantibodies; complement; lupus nephritis

Indexed keywords

ANTINUCLEAR ANTIBODY; COMPLEMENT COMPONENT C1Q ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CELL AGGREGATION; CELL STRUCTURE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRON MICROSCOPY; FEMALE; GLOMERULONEPHRITIS; HISTOPATHOLOGY; HYALINE DEGENERATION; IMMUNOFLUORESCENCE; KIDNEY HYPERTROPHY; KIDNEY INJURY; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPH FOLLICLE; MICROSCOPY; MORTALITY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEINURIA; QUANTITATIVE ANALYSIS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; BIOLOGICAL MARKERS; COMPLEMENT C1Q; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLOMERULONEPHRITIS; HUMANS; IMMUNOENZYME TECHNIQUES; LUPUS NEPHRITIS; MICE; MICE, INBRED BALB C; SURVIVAL RATE;

EID: 79953873693     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq558     Document Type: Article

References (20)

1. Moroni G, Trendelenburg M, Del Papa N et al. Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis. Am J Kidney Dis 2001; 37: 490-498 (Pubitemid 32195287)
2. Grootscholten C, Dieker JWC, McGrath FD et al. A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/ methylprednisolone. Ann Rheum Dis 2007; 66: 693-696 (Pubitemid 46707143)
3. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol 1985; 37: 269-390 (Pubitemid 15093080)
4. Peutz-Kootstra CJ, de Heer E, Hoedemaeker PJ et al. Lupus nephritis: lessons from experimental animal models. J Lab Clin Med 2001; 137: 244-260 (Pubitemid 32296062)
5. Andrews BS, Eisenberg RA, Theofilopoulos AN et al. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 1978; 148: 1198-1215 (Pubitemid 9053639)
6. Hogarth MB, Norsworthy PJ, Allen PJ et al. Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice. Clin Exp Immunol 1996; 104: 241-246 (Pubitemid 26135439)
7. Trinder PK, Maeurer MJ, Schorlemmer HU et al. Autoreactivity to mouse C1q in a murine model of SLE. Rheumatol Int 1995; 15: 117-120
8. Uwatoko S, Mannik M, Oppliger IR et al. C1q-binding immuno-globulin G in MRL/l mice consists of immune complexes containing antibodies to DNA. Clin Immunol Immunopathol 1995; 75: 140-146
9. Trouw LA, Seelen MA, Visseren R et al. Anti-C1q autoantibodies in murine lupus nephritis. Clin Exp Immunol 2004; 135: 41-48 (Pubitemid 38067926)
10. Hewicker M, Kromschröder E, Trautwein G. The pathogenesis of glomerulonephritis in MRL mice - murine lupus erythematosus. Verh Dtsch Ges Pathol 1989; 73: 129-132
11. Mitchell DA, Pickering MC, Warren J et al. C1q deficiency and auto-immunity: the effects of genetic background on disease expression. J Immunol 2002; 168: 2538-2543 (Pubitemid 34171862)
12. Trendelenburg M, Manderson AP, Fossati-Jimack L et al. Monocy-tosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice. Immunology 2004; 113: 80-88 (Pubitemid 39178846)
13. Bigler C, Schaller M, Perahud I et al. Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells. J Immunol 2009; 183: 3512-3521
14. Bénard A, Ceredig R, Rolink AG. Regulatory T cells control auto-immunity following syngeneic bone marrow transplantation. Eur J Immunol 2006; 36: 2324-2335 (Pubitemid 44420589)
15. Gunn HC, Ryffel B. Glomerulonephritis in NZB/W mice: therapeutic effect of cyclosporine. Clin Nephrol 1986; 25: 1189-192
16. Mannik M, Wener M. Deposition of antibodies to the collagen-like region of C1q in renal glomeruli of patients with proliferative lupus glomerulonephritis. Arthritis Rheum 1997; 40: 1504-1511 (Pubitemid 27430963)
17. Cortes-Hernandez J, Fossati-Jimack L, Petry F et al. Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice. Eur J Immunol 2004; 34: 3713-3722 (Pubitemid 40012189)
18. Trouw LA, Groeneveld TWL, Seelen MA et al. Anti-C1q autoanti-bodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. J Clin Invest 2004; 114: 679-688 (Pubitemid 39578758)
19. Trouw LA, Seelen MA, Duijs JMGJ et al. Glomerular deposition of C1q and anti-C1q antibodies in mice following injection of anti-mouse C1q antibodies. Clin Exp Immunol 2003; 132: 32-39 (Pubitemid 36422600)
20. Davis MM. A prescription for human immunology. Immunity 2008; 29: 835-838