C1q complement component and antibodies reflect SLE activity and kidney involvement

Clinical Rheumatology

Volumn 25, Issue 4, 2006, Pages 532-536

  Horak P ^a   Hermanova Z ^a   Zadrazil J ^a   Ciferska H ^a   Ordeltova M ^a   Kusa L ^a   Zurek M ^a   Tichy T ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Anti C1q antibody; C1q; Disease activity; Lupus nephritis; Systemic lupus erythematosus

Indexed keywords

ANTIBODY; COMPLEMENT COMPONENT C1Q;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; CLINICAL ASSESSMENT; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNODIFFUSION; IMMUNOPATHOGENESIS; KIDNEY BIOPSY; LABORATORY DIAGNOSIS; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 33746592933     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-005-0110-4     Document Type: Article

References (26)

1. Herrmann M, Voll RE, Lolowos W et al (2000) Pathogenesis of systemic lupus erythematosus. Immunologist 8:345-350
2. Walport MJ (2002) Complement and systemic lupus erythematosus. Arthritis Res 4[Suppl 3]:S279-S293
3. Botto M, Walport MJ (2002) C1q, autoimmunity and apoptosis. Immunobiology 205:395-406
4. Monova D, Monov S, Rosenova K et al (2002) Autoantibodies against C1q: view on association between systemic lupus erythematosus disease manifestation and C1q autoantibodies. Ann Rheum Dis 61:563-564
5. Pickering MC, Walport MJ (2003) The complement system. In: Hochberg MC, Silman AJ, Smolen JS (eds) Rheumatology. 3rd edn, Mosby, pp 1323-1336
6. Tan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277
7. Bencivelli W, Vitali C, Isenberg DA et al and the European Consensus Study Group for Disease Activity in SLE (1992) Disease activity in systemic lupus erythematosus: Report of the consensus study group of the European workshop for rheumatology research. III. Development of a computerized clinical chart and its application to the comparison of different indices of disease activity. Clin Exp Rheumatol 10:549-554
8. Bombardier C, Gladman DD, Urowitz MB et al. and The comittee on prognosis studies in SLE: Derivation of SLEDAI (1992) Arthritis Rheum 35:630-640
9. Fremeaux-Bacchi V, Noel LH, Schifferli JA (2002) No lupus nephritis in the absence of anti-C1q autoantibodies? Nephrol Dial Transplant 17:2041-2043
10. Gladman DD, Urowitz MB (1999) The SLICC/ACR damage index: Progress report and experience in the field. Lupus 8:632-637
11. Horvath L, Czirjak L, Fekete B et al. (2001) High levels of antibodies against Clq are associated with disease activity and nephritis but not with other organ manifestations in SLE patients. Clin Exp Rheumatol 19:667-672
12. Horák P, Hermanová Z, Ordeltová J et al (2004) C1q complement component and apoptotic indices of B and T lymphocytes in the group of patients with systemic lupus erythematosus. Ces revmatol 12:69-75 (Czech)
13. Navratil JS, Korb LC, Ahearn JM (1999) Systemic lupus erythematosus and complement deficiency: Clues to a novel role for the classical complement pathway in the maintenance of immune tolerance. Immunopharmacology 42:47-52
14. Trendelenburg M, Schifferli JA (2000) Apoptosis and C1q: Possible explanations for the pathogenesis of systemic lupus erythematosus. Z Rheumatol 59:172-175 (German)
15. Kumar A, Gupta R, Varghese T et al (1999) Anti-C1q antibody as a marker of disease activity in systemic lupus erythematosus. Indian J Med Res 10:190-193
16. Oelzner P, Deliyska B, Funfstuck R, Hein G, Herrmann D, Stein G (2003) Anti-C1q antibodies and antiendothelial cell antibodies in systemic lupus erythematosus - relationship with disease activity and renal involvement. Clin Rheumatol 22:271-278
17. Wisnieski JJ, Naff GB (1989) Serum IgG antibodies to C1q in hypocomplementemic urticarial vasculitis syndrome. Arthritis Rheum 32:1119-1127
18. Siegert CE, Daha MR (1998) C1q as antigen in humoral autoimmune responses. Immunobiology 199:295-302
19. Walport MJ, Davies KA, Botto M (1998) C1q and systemic lupus erythematosus. Immunobiology 199:265-285
20. Berner B, Scheel AK, Schettler V et al (2001) Rapid improvement of SLE-specific cutaneous lesions by C1q immunoadsorption. Ann Rheum Dis 80:898-899
21. Pfueller B, Wolbart K, Bruns A et al (2001) Successful treatment of patients with systemic lupus erythematosus by immunoadsorption with a C1q column: A pilot study. Arthritis Rheum 44:1962-1963
22. Stone NM, Williams A, Wilkinson JD et al (2000): Systemic lupus erythematosus with C1q deficiency. Br J Dermatol 142:521-524
23. Korb LC, Ahearn JM (1997) C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: Complement deficiency and systemic lupus erythematosus revisited. J Immunol 158:4525-4528
24. Pickering MC, Botto M, Taylor PR et al (2000) Systemic lupus erythematosus, complement deficiency, and apoptosis. Adv Immunol 76:227-234
25. Berkel AL, Petry F, Sanal O et al (1997) Development of systemic lupus erythematosus in a patient with selective complement C1q deficiency. Eur J Pediatr 156:113-115
26. Mitchell DA, Pickering MC, Warren J et al (2002) C1q deficiency and autoimmunity: The effects of genetic background on disease expression. J Immunol 168:2538-2543