DNA bacterial load in children with bacteremic pneumococcal community-acquired pneumonia

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 32, Issue 7, 2013, Pages 877-881

  Esposito, S ^a   Marchese, A ^b   Tozzi, A E ^c   Rossi, G A ^d   Da Dalt, L ^e   Bona, G ^f   Pelucchi, C ^g   Schito, G C ^b   Principi, N ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d G GASLINI INSTITUTE   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^g MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; PNEUMOCOCCUS VACCINE;

ARTICLE; BACTEREMIA; BACTERIAL LOAD; CHILD; CLINICAL FEATURE; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; EMPYEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PLEURA EFFUSION; PLEURA FLUID; PNEUMOCOCCAL INFECTION; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; SYMPTOMATOLOGY; THORAX RADIOGRAPHY;

BACTEREMIA; BACTERIAL LOAD; CHILD, PRESCHOOL; COMMUNITY-ACQUIRED INFECTIONS; DNA, BACTERIAL; EMPYEMA; FEMALE; HUMANS; INFANT; MALE; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE;

EID: 84879152846     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-013-1821-0     Document Type: Article

References (25)

1. Landsman JB (1952) Bacteriaemia and prognosis in lobar pneumonia: the results of quantitative blood culture in pneumococcus pneumonia. Glasgow Med J 33:33-45
2. Christie IM (1953) Bacteraemia in lobar pneumonia. Lancet 2:804-805
3. Santosham M, Moxon ER (1977) Detection and quantitation of bacteremia in childhood. J Pediatr 91:719-721
4. Sullivan TD, La Scolea LJ Jr, Neter E (1982) Relationship between the magnitude of bacteremia in children and the clinical disease. Pediatrics 69:699-702
5. Azzari C, Moriondo M, Indolfi G, Massai C, Becciolini L, de Martino M, Resti M (2008) Molecular detection methods and serotyping performed directly on clinical samples improve diagnostic sensitivity and reveal increased incidence of invasive disease by Streptococcus pneumoniae in Italian children. J Med Microbiol 57:1205-1212
6. Waterer G, Rello J (2011) Why should we measure bacterial load when treating community-acquired pneumonia? Curr Opin Infect Dis 24:137-141
7. DNA-Neumococo Study Group, Rello J, Lisboa T, Lujan M, Gallego M, Kee C, Kay I, Lopez D, Waterer GW (2009) Severity of pneumococcal pneumonia associated with genomic bacterial load. Chest 136:832-840
8. Peters RP, de Boer RF, Schuurman T, Gierveld S, Kooistra-Smid M, van Agtmael MA, Vandenbroucke-Grauls CM, Persoons MC, Savelkoul PH (2009) Streptococcus pneumoniae DNA load in blood as a marker of infection in patients with community-acquired pneumonia. J Clin Microbiol 47:3308-3312
9. Mortensen EM, Coley CM, Singer DE, Marrie TJ, Obrosky DS, Kapoor WN, Fine MJ (2002) Causes of death for patients with community-acquired pneumonia: results from the Pneumonia Patient Outcomes Research Team cohort study. Arch Intern Med 162:1059-1064
10. Carrol ED, Guiver M, Nkhoma S, Mankhambo LA, Marsh J, Balmer P, Banda DL, Jeffers G, White SA, Molyneux EM, Molyneux ME, Smyth RL, Hart CA, IPD Study Group (2007) High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease. Pediatr Infect Dis J 26:416-422
11. Munoz-Almagro C, Gala S, Selva L, Jordan J, Tarragò D, Pallares R (2011) DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema. Eur J Clin Microbiol Infect Dis 30:327-335
12. Lee GE, Lorch SA, Sheffler-Collins S, Kronman MP, Shah SS (2010) National hospitalization trends for pediatric pneumonia and associated complications. Pediatrics 126:204-213
13. Italian Pneumococcal CAP Group, Esposito S, Marchese A, Tozzi AE, Rossi GA, Da Dalt L, Bona G, Pelucchi C, Schito GC, Principi N (2012) Bacteremic pneumococcal community-acquired pneumonia in children less than 5 years of age in Italy. Pediatr Infect Dis J 31:705-710
14. World Health Organization. Pneumonia Vaccine Trial Investigators' Group (2001) Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children. WHO/V&B/01.35. World Health Organization, Geneva
15. Tan TQ, Mason EO Jr, Wald ER, Barson WJ, Schutze GE, Bradley JS, Givner LB, Yogev R, Kim KS, Kaplan SL (2002) Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics 110:1-6
16. Sawicki GS, Lu FL, Valim C, Cleveland RH, Colin AA (2008) Necrotising pneumonia is an increasingly detected complication of pneumonia in children. Eur Respir J 31:1285-1291
17. Marchese A, Esposito S, Coppo E, Rossi GA, Tozzi A, Romano M, Da Dalt L, Schito GC, Principi N (2011) Detection of Streptococcus pneumoniae and identification of pneumococcal serotypes by real-time polymerase chain reaction using blood samples from Italian children ≤5 years of age with community-acquired pneumonia. Microb Drug Resist 17:419-424
18. Park HK, Lee HJ, Kim W (2010) Real-time PCR assays for the detection and quantification of Streptococcuspneumoniae. FEMS Microbiol Lett 310:48-53
19. Grijalva CG, Nuorti JP, Arbogast PG, Martin SW, Edwards KM, Griffin MR (2007) Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis. Lancet 369:1179-1186
20. Li ST, Tancredi DJ (2010) Empyema hospitalizations increased in US children despite pneumococcal conjugate vaccine. Pediatrics 125:26-33
21. Chibuk TK, Robinson JL, Hartfield DS (2010) Pediatric complicated pneumonia and pneumococcal serotype replacement: trends in hospitalized children pre and post introduction of routine vaccination with pneumococcal conjugate vaccine (PCV7). Eur J Pediatr 169:1123-1128
22. Walker W, Wheeler R, Legg J (2011) Update on the causes, investigation and management of empyema in childhood. Arch Dis Child 96:482-488
23. Lai CY, Huang LM, Lee PY, Lu CY, Shao PL, Chang LY (2012) Comparison of invasive pneumococcal disease caused by serotype19A and non-19A pneumococci in children: more empyema in serotype19A invasive pneumococcal disease. J Microbiol Immunol Infect S1684-1182(12)00172-7. doi: 10.1016/j.jmii.2012.08.011.
24. van Hoek AJ, Andrews N, Waight PA, George R, Miller E (2012) Effect of serotype on focus and mortality of invasive pneumococcal disease: coverage of different vaccines and insight into non-vaccine serotypes. PLoSOne7:e39150.
25. Ritchie ND, Mitchell TJ, Evans TJ (2012) What is different about serotype 1 pneumococci? Future Microbiol 7:33-46