Aerobic Interval Training Partly Reverse Contractile Dysfunction and Impaired Ca2+ Handling in Atrial Myocytes from Rats with Post Infarction Heart Failure

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Johnsen, Anne Berit ^a   Høydal, Morten ^a   Røsbjørgen, Ragnhild ^a   Stølen, Tomas ^a   Wisløff, Ulrik ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

AEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM HANDLING IMPAIRMENT; CALCIUM TRANSIENT DECAY; CARDIOVASCULAR PARAMETERS; CONTRACTILE DYSFUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CONTROL; ENZYME ACTIVITY; FEMALE; HEART ATRIUM; HEART DISEASE; HEART FAILURE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE RELAXATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; RAT; SARCOPLASMIC RETICULUM; THERAPY EFFECT;

ANIMALS; CAFFEINE; CALCIUM; CALCIUM SIGNALING; CARDIOTONIC AGENTS; ELECTRIC STIMULATION; EXERCISE THERAPY; FEMALE; HEART ATRIA; MUSCLE CELLS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; OXYGEN CONSUMPTION; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES;

RATTUS;

EID: 84879148806     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066288     Document Type: Article

References (42)

1. Bers DM, (2006) Altered cardiac myocyte Ca regulation in heart failure. Physiology (Bethesda) 21: 380-387.
2. Nattel S, (2002) New ideas about atrial fibrillation 50 years on. Nature 415: 219-226.
3. Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, et al. (1998) Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 98: 946-952.
4. Yeh YH, Wakili R, Qi XY, Chartier D, Boknik P, et al. (2008) Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol 1: 93-102.
5. Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, et al. (2009) Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol 46: 385-394.
6. Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients- A randomized study. Circulation 115: 3086-3094.
7. Wisloff U, Loennechen JP, Currie S, Smith GL, Ellingsen O, (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. Cardiovascular Research 54: 162-174.
8. Kemi OJ, MacQuaide N, Hoydal MA, Ellingsen O, Smith GL, et al. (2012) Exercise training corrects control of spontaneous calcium waves in hearts from myocardial infarction heart failure rats. J Cell Physiol 227: 20-26.
9. Loennechen JP, Stoylen A, Beisvag V, Wisloff U, Ellingsen O, (2001) Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart. Am J Physiol Heart Circ Physiol 280: H2902-2910.
10. Wisloff U, Helgerud J, Kemi OJ, Ellingsen O, (2001) Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 280: H1301-1310.
11. Shioya T, (2007) A simple technique for isolating healthy heart cells from mouse models. Journal of Physiological Sciences 57: 327-335.
12. Bers D (2001) Excitation-Contraction Coupling and Cardiac Contractile Force: 2nd ed. Dordrecht, the Netherlands: Kluwer Academic Publishers.
13. Shannon TR, Ginsburg KS, Bers DM, (2002) Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res 91: 594-600.
14. Bers DM, Eisner DA, Valdivia HH, (2003) Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res 93: 487-490.
15. Beuckelmann DJ, Nabauer M, Erdmann E, (1992) Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 85: 1046-1055.
16. Hobai IA, O'Rourke B, (2001) Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation 103: 1577-1584.
17. Armoundas AA, Rose J, Aggarwal R, Stuyvers BD, O'Rourke B, et al. (2007) Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. Am J Physiol Heart Circ Physiol 292: H1607-1618.
18. Bers DM, Pogwizd SM, Schlotthauer K, (2002) Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure. Basic Res Cardiol 97Suppl 1: I36-42.
19. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, et al. (2003) FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 113: 829-840.
20. Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM, (2005) Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res 97: 1314-1322.
21. Anderson ME, Brown JH, Bers DM, (2011) CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol 51: 468-473.
22. Wehrens XH, Lehnart SE, Reiken SR, Marks AR, (2004) Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res 94: e61-70.
23. MacLennan DH, Kranias EG, (2003) Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566-577.
24. Bers DM, (2002) Cardiac excitation-contraction coupling. Nature 415: 198-205.
25. Sun H, Gaspo R, Leblanc N, Nattel S, (1998) Cellular mechanisms of atrial contractile dysfunction caused by sustained atrial tachycardia. Circulation 98: 719-727.
26. Workman AJ, (2010) Cardiac adrenergic control and atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol 381: 235-249.
27. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, et al. (2004) Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science 304: 292-296.
28. Chelu MG, Wehrens XH, (2007) Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans 35: 952-956.
29. Hasenfuss G, Pieske B, (2002) Calcium cycling in congestive heart failure. Journal of Molecular and Cellular Cardiology 34: 951-969.
30. Nattel S, Maguy A, Le Bouter S, Yeh YH, (2007) Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 87: 425-456.
31. Hasenfuss G, (1998) Calcium pump overexpression and myocardial function. Implications for gene therapy of myocardial failure. Circ Res 83: 966-968.
32. Hove-Madsen L, Llach A, Bayes-Genis A, Roura S, Rodriguez Font E, et al. (2004) Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes. Circulation 110: 1358-1363.
33. Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, et al. (2009) CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation. Circ Res.
34. El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, et al. (2006) Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation. Circulation 114: 670-680.
35. Schotten U, Greiser M, Benke D, Buerkel K, Ehrenteidt B, et al. (2002) Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort. Cardiovasc Res 53: 192-201.
36. Hasenfuss G, Schillinger W, Lehnart SE, Preuss M, Pieske B, et al. (1999) Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation 99: 641-648.
37. Pogwizd SM, (2000) Increased Na+-Ca2+ exchanger in the failing heart. Circ Res 87: 641-643.
38. Pogwizd SM, Qi M, Yuan W, Samarel AM, Bers DM, (1999) Upregulation of Na+/Ca2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 85: 1009-1019.
39. Kemi OJ, Hoydal MA, Haram PM, Garnier A, Fortin D, et al. (2007) Exercise training restores aerobic capacity and energy transfer systems in heart failure treated with losartan. Cardiovasc Res 76: 91-99.
40. Kemi OJ, Loennechen JP, Wisloff U, Ellingsen O, (2002) Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. Journal of Applied Physiology 93: 1301-1309.
41. Stolen TO, Hoydal MA, Kemi OJ, Catalucci D, Ceci M, et al. (2009) Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res 105: 527-536.
42. Curran J, Hinton MJ, Rios E, Bers DM, Shannon TR, (2007) Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res 100: 391-398.