Amygdala activation for eye contact despite complete cortical blindness

Journal of Neuroscience

Volumn 33, Issue 25, 2013, Pages 10483-10489

  Burra, Nicolas ^b   Hervais Adelman, Alexis ^b,c   Kerzel, Dirk ^b   Tamietto, Marco ^d,f   de Gelder, Beatrice ^d,e   Pegna, Alan J ^a,b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d TILBURG UNIVERSITY   (Netherlands)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BEHAVIOR; BOLD SIGNAL; CEREBRAL BLINDNESS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GAZE; HUMAN; INFORMATION PROCESSING; LINGUAL GYRUS; MALE; OCCIPITAL GYRUS; PRIORITY JOURNAL; VISUAL CORTEX; VISUAL STIMULATION;

ADULT; AMYGDALA; BLINDNESS, CORTICAL; BRAIN MAPPING; EXPRESSED EMOTION; EYE; FEMALE; FIXATION, OCULAR; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OCCIPITAL LOBE; OXYGEN CONSUMPTION; PHOTIC STIMULATION; SOCIAL BEHAVIOR; STROKE; VISUAL CORTEX; VISUAL FIELDS;

EID: 84879134686     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3994-12.2013     Document Type: Article

References (37)

1. Adams RB Jr, Kleck RE (2003) Perceived gaze direction and the processing of facial displays of emotion. Psychol Sci 14:644-647. CrossRef Medline
2. Adams RB Jr, Kleck RE (2005) Effects of direct and averted gaze on the perception of facially communicated emotion. Emotion 5:3-11. CrossRef Medline
3. Adams RB Jr, Franklin RG Jr, Kveraga K, Ambady N, Kleck RE, Whalen PJ, Hadjikhani N, Nelson AJ (2012) Amygdala responses to averted vs direct gaze fear vary as a function of presentation speed. Soc Cogn Affect Neurosci 7:568-577. CrossRef Medline
4. Ashburner J, Friston KJ (2005) Unified segmentation. Neuroimage 26:839-851. CrossRef Medline
5. Crinion J, Ashburner J, Leff A, Brett M, Price C, Friston K (2007) Spatial normalization of lesioned brains: performance evaluation and impact on fMRI analyses. Neuroimage 37:866-875. CrossRef Medline
6. de Gelder B, Vroomen J, Pourtois G, Weiskrantz L (1999) Non-conscious recognition of affect in the absence of striate cortex. Neuroreport 10: 3759-3763. CrossRef Medline
7. Delplanque S, N'diaye K, Scherer K, Grandjean D (2007) Spatial frequencies or emotional effects? A systematic measure of spatial frequencies for IAPS pictures by a discrete wavelet analysis. J Neurosci Methods 165:144-150. CrossRef Medline
8. Eickhoff SB, Stephan KE, Mohlberg H, Grefkes C, Fink GR, Amunts K, Zilles K (2005) A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage 25:1325-1335. CrossRef Medline
9. Ethofer T, Gschwind M, Vuilleumier P (2011) Processing social aspects of human gaze: a combined fMRI-DTI study. Neuroimage 55:411-419. CrossRef Medline
10. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ (1997) Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 6:218-229. CrossRef Medline
11. Gale A, Kingsley E, Brookes S, Smith D (1978) Cortical arousal and social intimacy in the human female under different conditions of eye contact. Behav Proc 3:271-275. CrossRef
12. George N, Driver J, Dolan RJ (2001) Seen gaze-direction modulates fusiform activity and its coupling with other brain areas during face processing. Neuroimage 13:1102-1112. CrossRef Medline
13. Hadjikhani N, Hoge R, Snyder J, de Gelder B (2008) Pointing with the eyes: the role of gaze in communicating danger. Brain Cogn 68:1-8. CrossRef Medline
14. Heywood CA, Cowey A (1992) The role of the 'face-cell' area in the discrimination and recognition of faces by monkeys. Philos Trans R Soc London 335:31-37; discussion 37-38. CrossRef Medline
15. Hoffman EA, Haxby JV (2000) Distinct representations of eye gaze and identity in the distributed human neural system for face perception. Nat Neurosci 3:80-84. CrossRef Medline
16. Holmes G (1918) Disturbances of vision by cerebral lesions. Br J Ophthalmol 2:353-384. CrossRef Medline
17. Kawashima R, Sugiura M, Kato T, Nakamura A, Hatano K, Ito K, Fukuda H, Kojima S, Nakamura K (1999) The human amygdala plays an important role in gaze monitoring: a PET study. Brain 122:779-783. CrossRef Medline
18. Kleinke CL (1986) Gaze and eye contact: a research review. Psychol Bull 100:78-100. CrossRef Medline
19. Kobayashi H, Kohshima S (1997) Unique morphology of the human eye. Nature 387:767-768. CrossRef Medline
20. LeDoux J (1996) Emotional networks and motor control: a fearful view. Prog Brain Res 107:437-446. CrossRef Medline
21. LeDoux J (1998) Fear and the brain: where have we been, and where are we going? Biol Psychiatry 44:1229-1238. CrossRef Medline
22. LeDoux J (2012) Rethinking the emotional brain. Neuron 73:653-676. CrossRef Medline
23. Liddell BJ, Brown KJ, Kemp AH, Barton MJ, Das P, Peduto A, Gordon E, Williams LM (2005) A direct brainstem-amygdala-cortical 'alarm' system for subliminal signals of fear. Neuroimage 24:235-243. CrossRef Medline
24. Lobmaier JS, Tiddeman BP, Perrett DI (2008) Emotional expression modulates perceived gaze direction. Emotion 8:573-577. CrossRef Medline
25. Lobmaier JS, Perrett DI (2011) The world smiles at me: self-referential positivity bias when interpreting direction of attention. Cogn Emot 25:334-341. CrossRef Medline
26. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19:1233-1239. CrossRef Medline
27. Morris JS, DeGelder B, Weiskrantz L, Dolan RJ (2001) Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field. Brain 124:1241-1252. CrossRef Medline
28. Pageler NM, Menon V, Merin NM, Eliez S, Brown WE, Reiss AL (2003) Effect of head orientation on gaze processing in fusiform gyrus and superior temporal sulcus. Neuroimage 20:318-329. CrossRef Medline
29. Pegna AJ, Khateb A, Lazeyras F, Seghier ML (2005) Discriminating emotional faces without primary visual cortices involves the right amygdala. Nat Neurosci 8:24-25. CrossRef Medline
30. Perrett DI, Smith PA, Potter DD, Mistlin AJ, Head AS, Milner AD, Jeeves MA (1985) Visual cells in the temporal cortex sensitive to face view and gaze direction. Proc R Soc Lond B Biol Sci 223:293-317. CrossRef Medline
31. Pessoa L, Adolphs R (2010) Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nat Rev 11:773-783. CrossRef Medline
32. Tamietto M, de Gelder B (2010) Neural bases of the non-conscious perception of emotional signals. Nat Rev 11:697-709. CrossRef Medline
33. Tamietto M, Pullens P, de Gelder B, Weiskrantz L, Goebel R (2012) Subcortical connections to human amygdala and changes following destruction of the visual cortex. Curr Biol 22:1449-1455. CrossRef Medline
34. Vuilleumier P, Armony JL, Driver J, Dolan RJ (2003) Distinct spatial frequency sensitivities for processing faces and emotional expressions. Nat Neurosci 6:624-631. CrossRef Medline
35. Weiskrantz L (1986) Some aspects of memory functions and the temporal lobes. Acta Neurol Scand 109:69-74. Medline
36. Weiskrantz L, Warrington EK, Sanders MD, Marshall J (1974) Visual capacity in the hemianopic field following a restricted occipital ablation. Brain 97:709-728. CrossRef Medline
37. Whalen PJ, Kagan J, Cook RG, Davis FC, Kim H, Polis S, McLaren DG, Somerville LH, McLean AA, Maxwell JS, Johnstone T (2004) Human amygdala responsivity to masked fearful eye whites. Science 306:2061. CrossRef Medline