Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening

Biochemical and Biophysical Research Communications

Volumn 436, Issue 1, 2013, Pages 96-103

  Xu, Hongbo ^a   Chen, Xiaohong ^a   Huang, Junwei ^a   Deng, Weiwei ^c   Zhong, Qi ^a   Yue, Changli ^a   Wang, Pingzhang ^b,c   Huang, Zhigang ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Gene expression regulation; GPR65; Head and neck cancer; High through put screening assay; Matrix metalloproteinases

Indexed keywords

COMPLEMENTARY DNA; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; STROMELYSIN; TRANSCRIPTION FACTOR AP 1;

ADENOVIRUS; ARTICLE; AXL GENE; BINDING SITE; CANCER CELL; CELL INVASION; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INDUCTION; GENE OVEREXPRESSION; GPR4 GENE; GRP65 GENE; HEAD AND NECK CANCER; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYPOPHARYNX CANCER; LARYNX CANCER; PH; PRIORITY JOURNAL; PROMOTER REGION; TNFRSF10B GENE; VIRUS RECOMBINANT;

ADENOVIRIDAE; CELL LINE, TUMOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MATRIX METALLOPROTEINASE 3; PLASMIDS; PROMOTER REGIONS, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

ADENOVIRIDAE;

EID: 84879133192     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.065     Document Type: Article

References (24)

1. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
2. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2:161-174.
3. Kessenbrock K., Plaks V., Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010, 141:52-67.
4. Brinckerhoff C.E., Matrisian L.M. Matrix metalloproteinases: a tail of a frog that became a prince. Nat. Rev. Mol. Cell Biol. 2002, 3:207-214.
5. Yan C., Boyd D.D. Regulation of matrix metalloproteinase gene expression. J. Cell. Physiol. 2007, 211:19-26.
6. Long W., Foulds C.E., Qin J., Liu J., Ding C., Lonard D.M., Solis L.M., Wistuba II, Tsai S.Y., Tsai M.J., O'Malley B.W. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J. Clin. Invest. 2012, 122:1869-1880.
7. Haddad R.I., Shin D.M. Recent advances in head and neck cancer. N. Engl. J. Med. 2008, 359:1143-1154.
8. Stokes A., Joutsa J., Ala-Aho R., Pitchers M., Pennington C.J., Martin C., Premachandra D.J., Okada Y., Peltonen J., Grenman R., James H.A., Edwards D.R., Kahari V.M. Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. Clin. Cancer Res. 2010, 16:2022-2035.
9. Katayama A., Bandoh N., Kishibe K., Takahara M., Ogino T., Nonaka S., Harabuchi Y. Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin. Cancer Res. 2004, 10:634-640.
10. Lee S.Y., Park S.Y., Kim S.H., Choi E.C. Expression of matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the tonsil and their clinical significance. Clin. Exp. Otorhinolaryngol. 2011, 4:88-94.
11. Westermarck J., Kahari V.M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999, 13:781-792.
12. Wang L., Gao X., Gao P., Deng W., Yu P., Ma J., Guo J., Wang X., Cheng H., Zhang C., Yu C., Ma X., Lv B., Lu Y., Shi T., Ma D. Cell-based screening and validation of human novel genes associated with cell viability. J. Biomol. Screen. 2006, 11:369-376.
13. Tian L., Wang P., Guo J., Wang X., Deng W., Zhang C., Fu D., Gao X., Shi T., Ma D. Screening for novel human genes associated with CRE pathway activation with cell microarray. Genomics 2007, 90:28-34.
14. Kato Y., Lambert C.A., Colige A.C., Mineur P., Noel A., Frankenne F., Foidart J.M., Baba M., Hata R., Miyazaki K., Tsukuda M. Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling. J. Biol. Chem. 2005, 280:10938-10944.
15. Wang P., Guo J., Wang F., Shi T., Ma D. Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells. Mol. Biol. Rep. 2011, 38:3551-3559.
16. Kato Y., Nakayama Y., Umeda M., Miyazaki K. Induction of 103-kDa gelatinase/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines. J. Biol. Chem. 1992, 267:11424-11430.
17. Lappano R., Maggiolini M. G protein-coupled receptors: novel targets for drug discovery in cancer. Nat. Rev. Drug Discov. 2011, 10:47-60.
18. Dorsam R.T., Gutkind J.S. G-protein-coupled receptors and cancer. Nat. Rev. Cancer 2007, 7:79-94.
19. Radu C.G., Nijagal A., McLaughlin J., Wang L., Witte O.N. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc. Natl. Acad. Sci. USA 2005, 102:1632-1637.
20. Ihara Y., Kihara Y., Hamano F., Yanagida K., Morishita Y., Kunita A., Yamori T., Fukayama M., Aburatani H., Shimizu T., Ishii S. The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor. Proc. Natl. Acad. Sci. USA 2010, 107:17309-17314.
21. Ishii S., Kihara Y., Shimizu T. Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. J. Biol. Chem. 2005, 280:9083-9087.
22. Sin W.C., Zhang Y., Zhong W., Adhikarakunnathu S., Powers S., Hoey T., An S., Yang J. G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. Oncogene 2004, 23:6299-6303.
23. Wyder L., Suply T., Ricoux B., Billy E., Schnell C., Baumgarten B.U., Maira S.M., Koelbing C., Ferretti M., Kinzel B., Muller M., Seuwen K., Ludwig M.G. Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor. Angiogenesis 2011, 14:533-544.
24. Sternlicht M.D., Lochter A., Sympson C.J., Huey B., Rougier J.P., Gray J.W., Pinkel D., Bissell M.J., Werb Z. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 1999, 98:137-146.