A role for PVRL4-driven cell-cell interactions in tumorigenesis

eLife

Volumn 2013, Issue 2, 2013, Pages

  Pavlova, Natalya N ^a,b   Pallasch, Christian ^c,f   Elia, Andrew E H ^a,b,d   Braun, Christian J ^c   Westbrook, Thomas F ^e   Hemann, Michael ^c   Elledge, Stephen J ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f University of Cologne   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; CYTOKERATIN 6; INVOLUCRIN; POLIOVIRUS RECEPTOR LIKE 4 PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BETA4 INTEGRIN; ITGB4 PROTEIN, HUMAN; LNIR PROTEIN, HUMAN; MONOCLONAL ANTIBODY; NECTINS;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CARCINOGENESIS; CELL ADHESION; CELL INTERACTION; CLONOGENIC ASSAY; COLONY FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC SCREENING; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL COMMUNICATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; COPY NUMBER VARIATION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL ADHESION; CELL ADHESION MOLECULES; CELL COMMUNICATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA COPY NUMBER VARIATIONS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; INTEGRIN BETA4; MICE, NUDE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TIME FACTORS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84879040830     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.00358     Document Type: Article

References (44)

1. Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A, Muschel RJ. 2000. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med 6:100-2. doi: 10.1038/71429.
2. Athanassiadou AM, Patsouris E, Tsipis A, Gonidi M, Athanassiadou P. 2011. The significance of Survivin and Nectin-4 expression in the prognosis of breast carcinoma. Folia Histochem Cytobiol 49:26-33. doi: 10.5603/4140.
3. Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. 2010. The landscape of somatic copy-number alteration across human cancers. Nature 463:899-905. doi: 10.1038/nature08822.
4. Bon G, Folgiero V, Bossi G, Felicioni L, Marchetti A, Sacchi A, et al. 2006. Loss of beta4 integrin subunit reduces the tumorigenicity of MCF7 mammary cells and causes apoptosis upon hormone deprivation. Clin Cancer Res 12:3280-7. doi: 10.1158/1078-0432.CCR-05-2223.
5. Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. 2012. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401-4. doi: 10.1158/2159-8290.CD-12-0095.
6. Chen Q, Zhang XH, Massague J. 2011. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 20:538-49. doi: 10.1016/j.ccr.2011.08.025.
7. Cho EH, Wendel M, Luttgen M, Yoshioka C, Marrinucci D, Lazar D, et al. 2012. Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol 9:016001. doi: 10.1088/1478-3975/9/1/016001.
8. Derycke MS, Pambuccian SE, Gilks CB, Kalloger SE, Ghidouche A, Lopez M, et al. 2010. Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker. Am J Clin Pathol 134:835-45. doi: 10.1309/AJCPGXK0FR4MHIHB.
9. Diaz LK, Cristofanilli M, Zhou X, Welch KL, Smith TL, Yang Y, et al. 2005. Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer. Mod Pathol 18:1165-75. doi: 10.1038/modpathol.3800411.
10. Elias JE, Gygi SP. 2007. Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods 4:207-14. doi: 10.1038/nmeth1019.
11. Fabre-Lafay S, Monville F, Garrido-Urbani S, Berruyer-Pouyet C, Ginestier C, Reymond N, et al. 2007. Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer 7:73. doi: 10.1186/1471-2407-7-73.
12. Fournier G, Cabaud O, Josselin E, Chaix A, Adelaide J, Isnardon D, et al. 2011. Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth. Oncogene 30:3862-74. doi: 10.1038/onc.2011.106.
13. Friedl P, Gilmour D. 2009. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 10:445-57. doi: 10.1038/nrm2720.
14. Frisch SM, Screaton RA. 2001. Anoikis mechanisms. Curr Opin Cell Biol 13:555-62. doi: 10.1016/S0955-0674(00)00251-9.
15. Giancotti FG. 2007. Targeting integrin beta4 for cancer and anti-angiogenic therapy. Trends Pharmacol Sci 28:506-11. doi: 10.1016/j.tips.2007.08.004.
16. Hoshino T, Sakisaka T, Baba T, Yamada T, Kimura T, Takai Y. 2005. Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn. J Biol Chem 280:24095-103. doi: 10.1074/jbc.M414447200.
17. Hou JM, Krebs M, Ward T, Sloane R, Priest L, Hughes A, et al. 2011. Circulating tumor cells as a window on metastasis biology in lung cancer. Am J Pathol 178:989-96. doi: 10.1016/j.ajpath.2010.12.003.
18. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, et al. 2010. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143:1174-89. doi: 10.1016/j.cell.2010.12.001.
19. Hynes RO. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673-87. doi: 10.1016/S0092-8674(02)00971-6.
20. Jelani M, Chishti MS, Ahmad W. 2011. Mutation in PVRL4 gene encoding nectin-4 underlies ectodermal-dysplasia-syndactyly syndrome (EDSS1). J Hum Genet 56:352-7. doi: 10.1038/jhg.2011.18.
21. Kondo T, Minamino N, Nagamura-Inoue T, Matsumoto M, Taniguchi T, Tanaka N. 1997. Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity. Oncogene 15:1275-81. doi: 10.1038/sj.onc.1201286.
22. Labelle M, Begum S, Hynes RO. 2011. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20:576-90. doi: 10.1016/j.ccr.2011.09.009.
23. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, et al. 2010. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene 29:635-46. doi: 10.1038/onc.2009.365.
24. Leskov I, Pallasch CP, Drake A, Iliopoulou BP, Souza A, Shen CH, et al. 2012. Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies. Oncogene 32:1066-72. doi: 10.1038/onc.2012.117.
25. Letessier A, Garrido-Urbani S, Ginestier C, Fournier G, Esterni B, Monville F, et al. 2007. Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer. Oncogene 26:298-307. doi: 10.1038/sj.onc.1209772.
26. Lipscomb EA, Dugan AS, Rabinovitz I, Mercurio AM. 2003. Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis 20:569-76. doi: 10.1023/A:1025819521707.
27. Lu S, Simin K, Khan A, Mercurio AM. 2008. Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res 14:1050-8. doi: 10.1158/1078-0432.CCR-07-4116.
28. Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS. 2007. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell 12:221-34. doi: 10.1016/j.devcel.2006.12.003.
29. Merdek KD, Yang X, Taglienti CA, Shaw LM, Mercurio AM. 2007. Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem 282:30322-30. doi: 10.1074/jbc.M703156200.
30. Molnar B, Ladanyi A, Tanko L, Sreter L, Tulassay Z. 2001. Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients. Clin Cancer Res 7:4080-5.
31. Muhlebach MD, Mateo M, Sinn PL, Prufer S, Uhlig KM, Leonard VH, et al. 2011. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature 480:530-3. doi: 10.1038/nature10639.
32. Noyce RS, Bondre DG, Ha MN, Lin LT, Sisson G, Tsao MS, et al. 2011. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog 7:e1002240. doi: 10.1371/journal.ppat.1002240.
33. Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, et al. 2004. Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods 1:163-7. doi: 10.1038/nmeth1104-163.
34. Reymond N, Fabre S, Lecocq E, Adelaide J, Dubreuil P, Lopez M. 2001. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J Biol Chem 276:43205-15. doi: 10.1074/jbc.M103810200.
35. Rual JF, Hirozane-Kishikawa T, Hao T, Bertin N, Li S, Dricot A, et al. 2004. Human ORFeome version 1.1: a platform for reverse proteomics. Genome Res 14:2128-35. doi: 10.1101/gr.2973604.
36. Saiki I, Naito S, Yoneda J, Azuma I, Price JE, Fidler IJ. 1991. Characterization of the invasive and metastatic phenotype in human renal cell carcinoma. Clin Exp Metastasis 9:551-66. doi: 10.1007/BF01768583.
37. Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, et al. 2010. Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci USA 107:18392-7. doi: 10.1073/pnas.1012539107.
38. Takai Y, Miyoshi J, Ikeda W, Ogita H. 2008. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat Rev Mol Cell Biol 9:603-15. doi: 10.1038/nrm2457.
39. Takano A, Ishikawa N, Nishino R, Masuda K, Yasui W, Inai K, et al. 2009. Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res 69:6694-703. doi: 10.1158/0008-5472.CAN-09-0016.
40. Updyke TV, Nicolson GL. 1986. Malignant melanoma cell lines selected in vitro for increased homotypic adhesion properties have increased experimental metastatic potential. Clin Exp Metastasis 4:273-84. doi: 10.1007/BF00133592.
41. Walmod PS, Kolkova K, Berezin V, Bock E. 2004. Zippers make signals: NCAM-mediated molecular interactions and signal transduction. Neurochem Res 29:2015-35. doi: 10.1007/s11064-004-6875-z.
42. Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, et al. 2005. A genetic screen for candidate tumor suppressors identifies REST. Cell 121:837-48. doi: 10.1016/j.cell.2005.03.033.
43. Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, et al. 2009. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 10:R130. doi: 10.1186/gb-2009-10-11-r130.
44. Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, et al. 2003. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 3:483-95. doi: 10.1016/S1535-6108(03)00088-6.