Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17179-17189

  Sakabe, Jun Ichi ^a   Yamamoto, Mami ^b,c   Hirakawa, Satoshi ^a   Motoyama, Akira ^b   Ohta, Isao ^a   Tatsuno, Kazuki ^a   Ito, Taisuke ^a   Kabashima, Kenji ^d   Hibino, Toshihiko ^b   Tokura, Yoshiki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHISEIDO RESEARCH CENTER   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROSPRAY TANDEM MASS SPECTROMETRY; EXTRACELLULAR SPACE; HUMAN EPIDERMAL KERATINOCYTES; HUMAN KERATINOCYTES; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; PARTIAL PURIFICATION; PROTEOLYTIC PROCESSING;

AMINO ACIDS; BIOSYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SKIN;

PURIFICATION;

KALLIKREIN; PEPTIDASE; PEPTIDASE 5; PROFILAGGRIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; TANDEM MASS SPECTROMETRY;

DIFFERENTIATION; EPIDERMIS; RNA INTERFERENCE (RNAI); SERINE PROTEASE; SKIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELLS, CULTURED; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KALLIKREINS; KERATINOCYTES; MICE; MICE, INBRED C57BL; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEOLYSIS; RNA, SMALL INTERFERING; SKIN;

EID: 84879037023     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.476820     Document Type: Article

References (33)

1. Takahashi, M., and Tezuka, T. (2004) The content of free amino acids in the stratum corneum is increased in senile xerosis. Arch. Dermatol. Res. 295, 448-452 (Pubitemid 38468668)
2. Chavanas, S., Méchin, M. C., Nachat, R., Adoue, V., Coudane, F., Serre, G., and Simon, M. (2006) Peptidylarginine deiminases and deimination in biology and pathology. Relevance to skin homeostasis. J. Dermatol. Sci. 44, 63-72 (Pubitemid 44499006)
3. Moll, R., Franke, W. W., Schiller, D. L., Geiger, B., and Krepler, R. (1982) The catalog of human cytokeratins. Patterns of expression in normal epithelia, tumors and cultured cells. Cell 31, 11-24 (Pubitemid 13215192)
4. Roop, D. R., Hawley-Nelson, P., Cheng, C. K., and Yuspa, S. H. (1983) Keratin gene expression in mouse epidermis and cultured epidermal cells. Proc. Natl. Acad. Sci. U.S.A. 80, 716-720 (Pubitemid 13144429)
5. Roop, D. R., Lowy, D. R., Tambourin, P. E., Strickland, J., Harper, J. R., Balaschak, M., Spangler, E. F., and Yuspa, S. H. (1986) An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 323, 822-824 (Pubitemid 17168637)
6. Steinert, P. M., and Roop, D. R. (1988) Molecular and cellular biology of intermediate filaments. Annu. Rev. Biochem. 57, 593-625
7. Sandilands, A., Sutherland, C., Irvine, A. D., and McLean, W. H. (2009) Filaggrin in the frontline. Role in skin barrier function and disease. J. Cell Sci. 122, 1285-1294
8. Scott, I. R., and Harding, C. R. (1981) Studies on the synthesis and degradation of a high molecular weight, histidine-rich phosphoprotein from mammalian epidermis. Biochim. Biophys. Acta 669, 65-78 (Pubitemid 11090357)
9. Ramsden, M., Loehren, D., and Balmain, A. (1983) Identification of a rapidly labelled 350K histidine-rich protein in neonatal mouse epidermis. Differentiation 23, 243-249 (Pubitemid 13090319)
10. Lonsdale-Eccles, J. D., Resing, K. A., Meek, R. L., and Dale, B. A. (1984) High-molecular-weight precursor of epidermal filaggrin and hypothesis for its tandem repeating structure. Biochemistry 23, 1239-1245
11. Dale, B. A., and Ling, S. Y. (1979) Immunologic cross-reaction of stratum corneum basic protein and a keratohyalin granule protein. J. Invest. Dermatol. 72, 257-261 (Pubitemid 10141470)
12. Ball, R. D., Walker, G. K., and Bernstein, I. A. (1978) Histidine-rich proteins as molecular markers of epidermal differentiation. J. Biol. Chem. 253, 5861-5868 (Pubitemid 8405031)
13. Matsui, T., Miyamoto, K., Kubo, A., Kawasaki, H., Ebihara, T., Hata, K., Tanahashi, S., Ichinose, S., Imoto, I., Inazawa, J., Kudoh, J., and Amagai, M. (2011) SASPase regulates stratum corneum hydration through profilaggrin-to- filaggrin processing. EMBO Mol. Med. 3, 320-333
14. Caubet, C., Jonca, N., Brattsand, M., Guerrin, M., Bernard, D., Schmidt, R., Egelrud, T., Simon, M., and Serre, G. (2004) Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J. Invest. Dermatol. 122, 1235-1244 (Pubitemid 38651099)
15. Briot, A., Deraison, C., Lacroix, M., Bonnart, C., Robin, A., Besson, C., Dubus, P., and Hovnanian, A. (2009) Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J. Exp. Med. 206, 1135-1147
16. Borgoño, C. A., Michael, I. P., Komatsu, N., Jayakumar, A., Kapadia, R., Clayman, G. L., Sotiropoulou, G., and Diamandis, E. P. (2007) A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J. Biol. Chem. 282, 3640-3652 (Pubitemid 47084449)
17. Ishida-Yamamoto, A., Deraison, C., Bonnart, C., Bitoun, E., Robinson, R., O'Brien, T. J., Wakamatsu, K., Ohtsubo, S., Takahashi, H., Hashimoto, Y., Dopping-Hepenstal, P. J., McGrath, J. A., Iizuka, H., Richard, G., and Hovnanian, A. (2005) LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. J. Invest. Dermatol. 124, 360-366 (Pubitemid 40175883)
18. Deraison, C., Bonnart, C., Lopez, F., Besson, C., Robinson, R., Jayakumar, A., Wagberg, F., Brattsand, M., Hachem, J. P., Leonardsson, G., and Hovnanian, A. (2007) LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction. Mol. Biol. Cell 18, 3607-3619 (Pubitemid 47378698)
19. List, K., Szabo, R., Wertz, P. W., Segre, J., Haudenschild, C. C., Kim, S. Y., and Bugge, T. H. (2003) Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J. Cell Biol. 163, 901-910 (Pubitemid 37517896)
20. Leyvraz, C., Charles, R. P., Rubera, I., Guitard, M., Rotman, S., Breiden, B., Sandhoff, K., and Hummler, E. (2005) The epidermal barrier function is dependent on the serine protease CAP1/Prss8. J. Cell Biol. 170, 487- 496
21. Epp, N., Fürstenberger, G., Müller, K., de Juanes, S., Leitges, M., Hausser, I., Thieme, F., Liebisch, G., Schmitz, G., and Krieg, P. (2007) 12R-lipoxygenase deficiency disrupts epidermal barrier function. J. Cell Biol. 177, 173-182 (Pubitemid 46588410)
22. Kamata, Y., Taniguchi, A., Yamamoto, M., Nomura, J., Ishihara, K., Takahara, H., Hibino, T., and Takeda, A. (2009) Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids. J. Biol. Chem. 284, 12829-12836
23. Hibino, T., Fujita, E., Tsuji, Y., Nakanishi, J., Iwaki, H., Katagiri, C., and Momoi, T. (2010) Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody. J. Cell. Biochem. 109, 487-497
24. Kamata, Y., Yamamoto, M., Kawakami, F., Tsuboi, R., Takeda, A., Ishihara, K., and Hibino, T. (2011) Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner. Relevance to atopic dermatitis. J. Biol. Chem. 286, 8204-8212
25. Wu, Z., Meyer-Hoffert, U., Reithmayer, K., Paus, R., Hansmann, B., He, Y., Bartels, J., Gläser, R., Harder, J., and Schröder, J. M. (2009) Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin. J. Invest. Dermatol. 129, 1446-1458
26. Henry, J., Hsu, C. Y., Haftek, M., Nachat, R., de Koning, H. D., Gardinal-Galera, I., Hitomi, K., Balica, S., Jean-Decoster, C., Schmitt, A. M., Paul, C., Serre, G., and Simon, M. (2011) Hornerin is a component of the epidermal cornified cell envelopes. FASEB J. 25, 1567-1576
27. Wu, Z., Hansmann, B., Meyer-Hoffert, U., Gläser, R., and Schröder, J. M. (2009) Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family. PloS One 4, e5227
28. Söderberg, O., Leuchowius, K. J., Gullberg, M., Jarvius, M., Weibrecht, I., Larsson, L. G., and Landegren, U. (2008) Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay. Methods 45, 227-232
29. Yamamoto, M., Miyai, M., Matsumoto, Y., Tsuboi, R., and Hibino, T. (2012) Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form. J. Biol. Chem. 287, 32825-32834
30. Mildner, M., Jin, J., Eckhart, L., Kezic, S., Gruber, F., Barresi, C., Stremnitzer, C., Buchberger, M., Mlitz, V., Ballaun, C., Sterniczky, B., Födinger, D., and Tschachler, E. (2010) Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model. J. Invest. Dermatol. 130, 2286-2294
31. Sandilands, A., Brown, S. J., Goh, C. S., Pohler, E., Wilson, N. J., Campbell, L. E., Miyamoto, K., Kubo, A., Irvine, A. D., Thawer-Esmail, F., Munro, C. S., McLean, W. H., Kudoh, J., Amagai, M., and Matsui, T. (2012) Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin. J. Invest. Dermatol. 132, 1507-1510
32. Kawasaki, H., Nagao, K., Kubo, A., Hata, T., Shimizu, A., Mizuno, H., Yamada, T., and Amagai, M. (2012) Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J. Allergy Clin. Immunol. 129, 1538-1546.e6
33. Nemoto-Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H., and Shimizu, H. (2009) FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema. Br. J. Dermatol. 161, 1387-1390 Technology Technology