Antagonism of L-type Ca2+ channels CaV1.3 and Ca V1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4365-4373

  Kang, Soosung ^a   Cooper, Garry ^a,b   Dunne, Sara Fernandez ^a   Luan, Chi Hao ^a   James Surmeier, D ^b   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

1,4 Dihydropyrimidines; 4H Pyrans; Antagonism; CaV1.2 Ca2+ channel; CaV1.3 Ca2+ channel; FLIPR (Fluorometric imaging plate reader); L type calcium channel; Parkinson's disease

Indexed keywords

1 ETHYL 5 ISOPROPYL 4 ISOPROPYL 6 (3 NITROPHENYL) 2 OXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1 ISOPROPYL 5 METHYL 4 ISOPROPYL 6 (3 NITROPHENYL) 2 OXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1 ISOPROPYL 5 METHYL 4 METHYL 6 (3 NITROPHENYL) 2 OXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1 ISOPROPYL 5 METHYL 4 METHYL 6 (3 NITROPHENYL) 2 THIOXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1 METHYL 5 ISOPROPYL 4 METHYL 6 (3 NITROPHENYL) 2 OXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1 METHYL 5 ISOPROPYL 4 METHYL 6 (3 NITROPHENYL) 2 THIOXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1,3 DIETHOXYCARBONYL 5 (METHOXYCARBONYL) 6 METHYL 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 1,3 DIMETHOXYCARBONYL 5 (ISOPROPYLOXYCARBONYL) 6 METHYL 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 1,4 DIHYDROPYRIMIDINE; 1,5 DIISOPROPYL 4 ISOPROPYL 6 (3 NITROPHENYL) 2 OXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 1,5 DIISOPROPYL 4 METHYL 6 (3 NITROPHENYL) 2 OXO 2,3 DIHYDROPYRIMIDINE 1,5(6H) DICARBOXYLATE; 3 ETHYL 5 METHYL 2 AMINO 6 METHYL 4 (3 NITROPHENYL) 4H PYRAN 3,5 DICARBOXYLATE; 3 ISOPROPYL 5 METHYL 2 AMINO 6 METHYL 4 (3 NITROPHENYL) 4H PYRAN 3,5 DICARBOXYLATE; 3,5 DIISOPROPYL 2 AMINO 6 METHYL 4 (3 NITROPHENYL) 4H PYRAN 3,5 DICARBOXYLATE; 6 ISOPROPYL 5 (METHYOXYCARBONYL) 4 (3 NITROPHENYL) 3 ISOBUTYL 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 6 ISOPROPYL 5 (METHYOXYCARBONYL) 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 6 METHYL 5 (ISOPROPYLOXYCARBONYL) 4 (3 NITROPHENYL) 3 ISOBUTYL 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 6 METHYL 5 (ISOPROPYLOXYCARBONYL) 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 6 METHYL 5 (ISOPROPYLOXYCARBONYL) 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDINE 2(1H) THIONE; 6 METHYL 5 (METHYOXYCARBONYL) 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDIN 2(1H) ONE; 6 METHYL 5 (METHYOXYCARBONYL) 4 (3 NITROPHENYL) 3,4 DIHYDROPYRIMIDINE 2(1H) THIONE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL CAV1.3; CALCIUM CHANNEL L TYPE; ISRADIPINE; NITRENDIPINE; PYRAN DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING SITE; BIOASSAY; CALCIUM TRANSPORT; CHIRALITY; CONTROLLED STUDY; DNA SEQUENCE; DRUG DETERMINATION; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HYDROGEN BOND; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PROTEIN TARGETING;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DIHYDROPYRIDINES; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRANS;

ANIMALIA;

EID: 84879026017     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.054     Document Type: Article

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