Granulocyte-colony-stimulating factor treatment enhances Foxp3+ T lymphocytes and modifies the proinflammatory response in experimental autoimmune neuritis

CNS Neuroscience and Therapeutics

Volumn 19, Issue 7, 2013, Pages 529-532

  Pradella, Fernando ^a   Moraes, Adriel S ^a   Santos, Mariana P A ^a   Depaula, Rosemeire F O ^a   Degaki, Karina Y ^a   Longhini, Ana Leda F ^a   Silva, Vania D R ^a   Santos, Leonilda M B ^a   Farias, Alessandro S ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; PROTEIN P21; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

AUTOIMMUNE DISEASE; AUTOIMMUNE NEURITIS; CELL MIGRATION; CYTOKINE PRODUCTION; DISEASE COURSE; IMMUNIZATION; LETTER; LEWIS RAT; MONONUCLEAR CELL; MYELIN SHEATH; NEURITIS; PERIPHERAL NERVE; REGULATORY T LYMPHOCYTE; SENSITIZATION; SHORT COURSE THERAPY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; GRANULOCYTE COLONY-STIMULATING FACTOR; INFLAMMATION; MYELIN SHEATH; NEURITES; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; RATS; RATS, INBRED LEW; TH1 CELLS; TH17 CELLS;

EID: 84879011501     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12112     Document Type: Letter

References (10)

1. Hartung HP, Pollard JD, Harvey GK, Toyka KV. Immunopathogenesis and treatment of the Guillain-Barre syndrome-Part I. Muscle Nerve 1995;18:137-153.
2. Waksman BH, Adams RD. Allergic neuritis: an experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants. J Exp Med 1955;102:213-236.
3. Lu MO, Zhu J. The role of cytokines in Guillain-Barré syndrome. J Neurol 2011;258:533-548.
4. Sheng JR, Muthusamy T, Prabhakar BS, Meriggioli MN. GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis. J Neuroimmunol 2011;240-241:65-73.
5. Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008;8:533-544.
6. Castro FR, Farias AS, Proenca PL, et al. The effect of treatment with crotapotin on the evolution of experimental autoimmune neuritis induced in Lewis rats. Toxicon 2007;49:299-305.
7. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008;133:775-787.
8. Farias AS, Spagnol GS, Bordeaux-Rego P, et al. Vitamin D3 induces IDO+ tolerogenic DCs and enhances treg, reducing the severity of EAE. CNS Neurosci Ther 2013; 19:269-277.
9. Kerschensteiner M, Gallmeier E, Behrens L, et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 1999;189:865-870.
10. Franzke A, Piao W, Lauber J, et al. G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases. Blood 2003;102:734-739.