Neurotoxic effects of berberine on long-term l-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease

Archives of Pharmacal Research

Volumn 36, Issue 6, 2013, Pages 759-767

  Shin, Keon Sung ^a   Choi, Hyun Sook ^a   Zhao, Ting Ting ^a   Suh, Kwang Hoon ^a   Kwon, Ik Hyun ^a   Choi, Soon Ok ^a   Lee, Myung Koo ^a  

^a Chungbuk National University   (South Korea)

Author keywords

6 Hydroxydopamine lesioned rats; Berberine; Dopamine; l DOPA; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; BENSERAZIDE; BERBERINE; DOPAMINE; HOMOVANILLIC ACID; LEVODOPA; NORADRENALIN; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CELL SURVIVAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG EFFECT; LOCOMOTION; LONG TERM CARE; MALE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; RAT; SUBSTANTIA NIGRA;

ANIMALS; ANTIPARKINSON AGENTS; BERBERINE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; LEVODOPA; MALE; NEURONS; NEUROTOXICITY SYNDROMES; OXIDOPAMINE; PARKINSONIAN DISORDERS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA; TIME FACTORS;

EID: 84879003168     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0051-4     Document Type: Article

References (53)

1. Basma, A.N.; E.J. Morris, W.J. Nicklas, and H.M. Geller. 1995. l-dopa cytotoxicity to PC12 cells in culture is via its autoxidation. Journal of Neurochemistry 64: 825-832.
2. Blum, D.; S. Torch, N. Lambeng, M. Nissou, A.L. Benabid, R. Sadoul, and J.M. Verna. 2001. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Progress in Neurobiology 65: 135-172. (Pubitemid 32524182)
3. Cenci, M.A.; K.E. Ohlin, and D. Rylander. 2009. Plastic effects of l-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia. Parkinsonism & Related Disorder 15(Suppl 3): S59-S63.
4. Chae, Y.; C.H. Yang, Y.K. Kwon, M.R. Kim, K.H. Pyun, D.H. Hahm, H.J. Lee, and I. Shim. 2004. Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Neuroscience Letters 358: 87-90. (Pubitemid 38340727)
5. Cheng, N.; T. Maeda, T. Kume, S. Kaneko, H. Kochiyama, A. Akaike, Y. Goshima, and Y. Misu. 1996. Differential neurotoxicity induced by l-DOPA and dopamine in cultured striatal neurons. Brain Research 743: 278-283. (Pubitemid 27028782)
6. Deitrich, R.; and V. Erwin. 1980. Biogenic amine-aldehyde condensation products: tetrahydroisoquinolines and tryptolines (beta-carbolines). Annual Review of Pharmacology and Toxicology 20: 55-80.
7. Del Fiacco, M.; G. Paxinos, and A.C. Cuello. 1982. Neostriatal enkephalin-immunoreactive neurones project to the globus pallidus. Brain Research 231: 1-17. (Pubitemid 12194297)
8. Deumens, R.; A. Blokland, and J. Prickaerts. 2002. Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Experimental Neurology 175: 303-317. (Pubitemid 34634286)
9. Fearnley, J.M.; and A.J. Lees. 1991. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114(Pt 5): 2283-2301.
10. Fukuda, K.; Y. Hibiya, M. Mutoh, M. Koshiji, S. Akao, and H. Fujiwara. 1999. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. Journal of Ethnopharmacology 66: 227-233. (Pubitemid 29307925)
11. Guo, Y.; F. Li, X. Ma, X. Cheng, H. Zhou, and C.D. Klaassen. 2011. CYP2D plays a major role in berberine metabolism in liver of mice and humans. Xenobiotica 41: 996-1005.
12. Huang, W.M.; Z.D. Wu, and Y.Q. Gan. 1989. Effects of berberine on ischemic ventricular arrhythmia. Zhonghua Xin Xue Guan Bing Za Zhi 17: 300-301. 319.
13. Izurieta-Sanchez, P.; S. Sarre, G. Ebinger, and Y. Michotte. 1998. Effect of trihexyphenidyl, a non-selective antimuscarinic drug, on decarboxylation of l-dopa in hemi-Parkinson rats. European Journal of Pharmacology 353: 33-42. (Pubitemid 28352286)
14. Jantova, S.; L. Cipak, and S. Letasiova. 2007. Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicology in Vitro 21: 25-31. (Pubitemid 44855510)
15. Kim, S.H.; J.S. Shin, J.J. Lee, S.Y. Yin, M. Kai, and M.K. Lee. 2001. Effects of hydrastine derivatives on dopamine biosynthesis in PC12 cells. Planta Medica 67: 609-613. (Pubitemid 32929569)
16. Kim, Y.M.; M.N. Kim, J.J. Lee, and M.K. Lee. 2005. Inhibition of dopamine biosynthesis by tetrahydropapaveroline. Neuroscience Letters 386: 1-4. (Pubitemid 41019632)
17. Kim, Y.M.; J.J. Lee, S.K. Park, S.C. Lim, B.Y. Hwang, C.K. Lee, and M.K. Lee. 2007. Effects of tributyltin acetate on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells. Arch. Pharm. Res. 30: 858-865.
18. Kotake, Y.; Y. Tasaki, Y. Makino, S. Ohta, and M. Hirobe. 1995. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF. Journal of Neurochemistry 65: 2633-2638.
19. Kwon, I.H.; H.S. Choi, K.S. Shin, B.K. Lee, C.K. Lee, B.Y. Hwang, S.C. Lim, and M.K. Lee. 2010. Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease. Neuroscience Letters 486: 29-33.
20. Lee, J.J.; Y.M. Kim, S.Y. Yin, H.D. Park, M.H. Kang, J.T. Hong, and M.K. Lee. 2003. Aggravation of l-DOPA-induced neurotoxicity by tetrahydropapaveroline in PC12 cells. Biochemical Pharmacology 66: 1787-1795. (Pubitemid 37249323)
21. Lee, M.K.; and H.S. Kim. 1996. Inhibitory effects of protoberberine alkaloids from the roots of Coptis japonica on catecholamine biosynthesis in PC12 cells. Planta Medica 62: 31-34. (Pubitemid 26056306)
22. Lee, M.K.; and Y.H. Zhang. 1996. Inhibition of tyrosine hydroxylase by berberine. Medical Science Research 24: 561-562. (Pubitemid 26280691)
23. Lindner, M.D.; C.K. Cain, M.A. Plone, B.R. Frydel, T.J. Blaney, D.F. Emerich, and M.R. Hoane. 1999. Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats. Behavioural Brain Research 102: 1-16. (Pubitemid 29314564)
24. Marsden, C.D. 1994. Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry 57: 672-681. (Pubitemid 24182950)
25. Maruyama, W.; T. Abe, H. Tohgi, P. Dostert, and M. Naoi. 1996. A dopaminergic neurotoxin (R)-N-methylsalsolinol, increases in Parkinsonian cerebrospinal fluid. Annals of Neurology 40: 119-122. (Pubitemid 26250152)
26. Matsubara, K.; M.A. Collins, A. Akane, J. Ikebuchi, E.J. Neafsey, M. Kagawa, and H. Shiono. 1993. Potential bioactivated neurotoxicants, N-methylated beta-carbolinium ions, are present in human brain. Brain Research 610: 90-96. (Pubitemid 23144428)
27. Mena, M.A.; V. Davila, and D. Sulzer. 1997. Neurotrophic effects of l-DOPA in postnatal midbrain dopamine neuron/cortical astrocyte cocultures. Journal of Neurochemistry 69: 1398-1408. (Pubitemid 27406940)
28. Migheli, R.; C. Godani, L. Sciola, M.R. Delogu, P.A. Serra, D. Zangani, G. De Natale, E. Miele, and M.S. Desole. 1999. Enhancing effect of manganese on l-DOPA-induced apoptosis in PC12 cells: role of oxidative stress. Journal of Neurochemistry 73: 1155-1163. (Pubitemid 29395474)
29. Nagatsu, T. 1997. Isoquinoline neurotoxins in the brain and Parkinson's disease. Neuroscience Research 29: 99-111. (Pubitemid 27422504)
30. Nagatsu, T.; and M. Yoshida. 1988. An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions. Neuroscience Letters 87: 178-182. (Pubitemid 18094000)
31. Nutt, J.G. 1990. Levodopa-induced dyskinesia: review, observations, and speculations. Neurology 40: 340-345. (Pubitemid 20099455)
32. Ohta, S.; O. Tachikawa, Y. Makino, Y. Tasaki, and M. Hirobe. 1990. Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer. Life Sciences 46: 599-605. (Pubitemid 20070639)
33. Pandey, M.; A. Borah, M. Varghese, P.K. Barman, K.P. Mohanakumar, and R. Usha. 2009. Striatal dopamine level contributes to hydroxyl radical generation and subsequent neurodegeneration in the striatum in 3-nitropropionic acid-induced Huntington's disease in rats. Neurochemistry International 55: 431-437.
34. Peng, W.H.; K.L. Lo, Y.H. Lee, T.H. Hung, and Y.C. Lin. 2007. Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sciences 81: 933-938. (Pubitemid 47381365)
35. Peng, W.H.; C.R. Wu, C.S. Chen, C.F. Chen, Z.C. Leu, and M.T. Hsieh. 2004. Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. Life Sciences 75: 2451-2462. (Pubitemid 39180049)
36. Przedborski, S.; M. Levivier, C. Raftopoulos, A.B. Naini, and J. Hildebrand. 1995. Peripheral and central pharmacokinetics of apomorphine and its effect on dopamine metabolism in humans. Movement Disorders 10: 28-36.
37. Rommelspacher, H.; T. May, and B. Salewski. 1994. Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats. European Journal of Pharmacology 252: 51-59. (Pubitemid 24039458)
38. Saitoh, T.; Y. Mizuno, T. Nagatsu, and M. Yoshida. 1988. Effect of long-term administration of 1,2,3,4-tetrahydroisoquinoline (TIQ) on striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) content in mice. Neuroscience Letters 92: 321-324.
39. Sauer, H.; and W.H. Oertel. 1994. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59: 401-415. (Pubitemid 24098798)
40. Shin, J.S.; E.I. Kim, M. Kai, and M.K. Lee. 2000. Inhibition of dopamine biosynthesis by protoberberine alkaloids in PC12 cells. Neurochemical Research 25: 363-368. (Pubitemid 30161482)
41. Shin, J.S.; K.T. Kim, and M.K. Lee. 1998. Inhibitory effects of bulbocapnine on dopamine biosynthesis in PC12 cells. Neuroscience Letters 244: 161-164. (Pubitemid 28226316)
42. Shin, J.S.; H.S. Yun-Choi, E.I. Kim, and M.K. Lee. 1999. Inhibitory effects of higenamine on dopamine content in PC12 cells. Planta Medica 65: 452-455. (Pubitemid 29299841)
43. Takase, H.; K. Yamamoto, K. Ito, and E. Yumioka. 1993. Pharmacological studies on antidiarrheal effects of berberine and geranii herba. Nihon Yakurigaku Zasshi 102: 101-112. (Pubitemid 23278238)
44. Tang, W.; and G. Eisenbrand. 2011. Coptis chinensis, Coptis deltoidea and Coptis teeta, in: handbook of chinese medicinal plants, 384-396. Weinheim: Wiley-VCH.
45. Tasaki, Y.; Y. Makino, S. Ohta, and M. Hirobe. 1991. 1-Methyl-1,2,3,4- tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities. Journal of Neurochemistry 57: 1940-1943. (Pubitemid 21922843)
46. Wakabayashi, T.; Y. Motoo, Y. Kojima, H. Makino, and N. Sawabu. 1998. Chronic pancreatitis with diffuse irregular narrowing of the main pancreatic duct. Digestive Diseases and Sciences 43: 2415-2425. (Pubitemid 28531313)
47. Walkinshaw, G.; and C.M. Waters. 1995. Induction of apoptosis in catecholaminergic PC12 cells by l-DOPA. Implications for the treatment of Parkinson's disease. Journal of Clinical Investigation 95: 2458-2464.
48. Wang, X.; R. Wang, D. Xing, H. Su, C. Ma, Y. Ding, and L. Du. 2005. Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract. Life Sciences 77: 3058-3067. (Pubitemid 41423743)
49. 2+concentration in cultured brain cells. Yao Xue Xue Bao 32: 15-18. (Pubitemid 127464575)
50. Xiao, B.; F.F. Bi, Y.Q. Hu, F.F. Tian, Z.G. Wu, H.M. Mujlli, Ding, and X.F. Zhou. 2007. Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats. Neurotoxicity Research 12: 155-162.
51. Yang, Y.J.; J.J. Lee, C.M. Jin, S.C. Lim, and M.K. Lee. 2008. Effects of harman and norharman on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells. European Journal of Pharmacology 587: 57-64.
52. Yin, S.Y.; Y.M. Kim, J.J. Lee, C.M. Jin, Y.J. Yang, J.J. Ma, M.H. Kang, M. Kai, and M.K. Lee. 2004. Enantio-selective inhibition of (1R,9S)- and (1S,9R)-beta-hydrastines on dopamine biosynthesis in PC12 cells. Neuropharmacology 47: 1045-1052. (Pubitemid 39535843)
53. Zhou, X.Q.; X.N. Zeng, H. Kong, and X.L. Sun. 2008. Neuroprotective effects of berberine on stroke models in vitro and in vivo. Neuroscience Letters 447: 31-36.