Crucial Role for CD69 in the Pathogenesis of Dextran Sulphate Sodium-Induced Colitis

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Hasegawa, Akihiro ^a   Iwamura, Chiaki ^b   Kitajima, Masayuki ^b   Hashimoto, Kahoko ^c   Otsuyama, Ken ichiro ^a   Ogino, Hidetaka ^a   Nakayama, Toshinori ^b,d   Shirai, Mutsunori ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD69 ANTIGEN; CHEMOKINE; CYTOKINE; DEXTRAN SULFATE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CHRONIC DISEASE; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DEXTRAN SULPHATE SODIUM INDUCED COLITIS; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; LARGE INTESTINE; LETHALITY; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; WEIGHT REDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CHEMOKINES; COLITIS; COLON; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; LECTINS, C-TYPE; MICE; MICE, KNOCKOUT; RECEPTORS, CHEMOKINE; T-LYMPHOCYTE SUBSETS;

MUS;

EID: 84878991509     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065494     Document Type: Article

References (52)

1. Cong Y, Brandwein SL, McCabe RP, Lazenby A, Birkenmeier EH, et al. (1998) CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 187: 855-864.
2. Fiocchi C, (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205.
3. Maaser C, Kagnoff MF, (2002) Role of the intestinal epithelium in orchestrating innate and adaptive mucosal immunity. Z Gastroenterol 40: 525-529.
4. McKay DM, (1999) Intestinal inflammation and the gut microflora. Can J Gastroenterol 13: 509-516.
5. Sartor RB, (1997) The influence of normal microbial flora on the development of chronic mucosal inflammation. Res Immunol 148: 567-576.
6. Brandtzaeg P, Haraldsen G, Rugtveit J, (1997) Immunopathology of human inflammatory bowel disease. Springer Semin Immunopathol 18: 555-589.
7. Bouma G, Strober W, (2003) The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 3: 521-533.
8. Cobrin GM, Abreu MT, (2005) Defects in mucosal immunity leading to Crohn's disease. Immunol Rev 206: 277-295.
9. Fuss IJ, Neurath M, Boirivant M, Klein JS, de la Motte C, et al. (1996) Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157: 1261-1270.
10. Targan SR, Karp LC, (2005) Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev 206: 296-305.
11. Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, et al. (1993) Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 94: 174-181.
12. Podolsky DK, (2002) Inflammatory bowel disease. N Engl J Med 347: 417-429.
13. Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, et al. (1994) Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107: 1643-1652.
14. Dieleman LA, Palmen MJ, Akol H, Bloemena E, Pena AS, et al. (1998) Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol 114: 385-391.
15. Tsuchiya T, Fukuda S, Hamada H, Nakamura A, Kohama Y, et al. (2003) Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 171: 5507-5513.
16. Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, et al. (2002) The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 109: 883-893.
17. Annunziato F, Cosmi L, Galli G, Beltrame C, Romagnani P, et al. (1999) Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J Leukoc Biol 65: 691-699.
18. Banks C, Bateman A, Payne R, Johnson P, Sheron N, (2003) Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol 199: 28-35.
19. Connor SJ, Paraskevopoulos N, Newman R, Cuan N, Hampartzoumian T, et al. (2004) CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease. Gut 53: 1287-1294.
20. Grimm MC, Elsbury SK, Pavli P, Doe WF, (1996) Interleukin 8: cells of origin in inflammatory bowel disease. Gut 38: 90-98.
21. Jugde F, Alizadeh M, Boissier C, Chantry D, Siproudhis L, et al. (2001) Quantitation of chemokines (MDC, TARC) expression in mucosa from Crohn's disease and ulcerative colitis. Eur Cytokine Netw 12: 468-477.
22. Mazzucchelli L, Hauser C, Zgraggen K, Wagner HE, Hess MW, et al. (1996) Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J Pathol 178: 201-206.
23. McCormack G, Moriarty D, O'Donoghue DP, McCormick PA, Sheahan K, et al. (2001) Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm Res 50: 491-495.
24. Uguccioni M, Gionchetti P, Robbiani DF, Rizzello F, Peruzzo S, et al. (1999) Increased expression of IP-10, IL-8, MCP-1, and MCP-3 in ulcerative colitis. Am J Pathol 155: 331-336.
25. Matsushima K, Larsen CG, DuBois GC, Oppenheim JJ, (1989) Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 169: 1485-1490.
26. Schrum S, Probst P, Fleischer B, Zipfel PF, (1996) Synthesis of the CC-chemokines MIP-1alpha, MIP-1beta, and RANTES is associated with a type 1 immune response. J Immunol 157: 3598-3604.
27. Kolios G, Wright KL, Jordan NJ, Leithead JB, Robertson DA, et al. (1999) C-X-C and C-C chemokine expression and secretion by the human colonic epithelial cell line, HT-29: differential effect of T lymphocyte-derived cytokines. Eur J Immunol 29: 530-536.
28. Yang SK, Eckmann L, Panja A, Kagnoff MF, (1997) Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology 113: 1214-1223.
29. Andres PG, Beck PL, Mizoguchi E, Mizoguchi A, Bhan AK, et al. (2000) Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 164: 6303-6312.
30. Ziegler SF, Ramsdell F, Hjerrild KA, Armitage RJ, Grabstein KH, et al. (1993) Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. Eur J Immunol 23: 1643-1648.
31. Testi R, D'Ambrosio D, De Maria R, Santoni A, (1994) The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol Today 15: 479-483.
32. Sancho D, Gomez M, Sanchez-Madrid F, (2005) CD69 is an immunoregulatory molecule induced following activation. Trends Immunol 26: 136-140.
33. Siegmund B, Lehr HA, Fantuzzi G, Dinarello CA, (2001) IL-1 beta-converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci U S A 98: 13249-13254.
34. Guehler SR, Bluestone JA, Barrett TA, (1999) Activation and peripheral expansion of murine T-cell receptor gamma delta intraepithelial lymphocytes. Gastroenterology 116: 327-334.
35. Aranda R, Sydora BC, McAllister PL, Binder SW, Yang HY, et al. (1997) Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients. J Immunol 158: 3464-3473.
36. Nakayama T, Kasprowicz DJ, Yamashita M, Schubert LA, Gillard G, et al. (2002) The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J Immunol 168: 87-94.
37. Feng C, Woodside KJ, Vance BA, El-Khoury D, Canelles M, et al. (2002) A potential role for CD69 in thymocyte emigration. Int Immunol 14: 535-544.
38. Shiow LR, Rosen DB, Brdickova N, Xu Y, An J, et al. (2006) CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 440: 540-544.
39. Murata K, Inami M, Hasegawa A, Kubo S, Kimura M, et al. (2003) CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int Immunol 15: 987-992.
40. Sancho D, Gomez M, Viedma F, Esplugues E, Gordon-Alonso M, et al. (2003) CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. J Clin Invest 112: 872-882.
41. Miki-Hosokawa T, Hasegawa A, Iwamura C, Shinoda K, Tofukuji S, et al. (2009) CD69 controls the pathogenesis of allergic airway inflammation. J Immunol 183: 8203-8215.
42. Martin P, Gomez M, Lamana A, Matesanz Marin A, Cortes JR, et al. (2010) The leukocyte activation antigen CD69 limits allergic asthma and skin contact hypersensitivity. J Allergy Clin Immunol 126: 355-365, 365 e351-353.
43. Cruz-Adalia A, Jimenez-Borreguero LJ, Ramirez-Huesca M, Chico-Calero I, Barreiro O, et al. (2010) CD69 limits the severity of cardiomyopathy after autoimmune myocarditis. Circulation 122: 1396-1404.
44. Esplugues E, Sancho D, Vega-Ramos J, Martinez C, Syrbe U, et al. (2003) Enhanced antitumor immunity in mice deficient in CD69. J Exp Med 197: 1093-1106.
45. Esplugues E, Vega-Ramos J, Cartoixa D, Vazquez BN, Salaet I, et al. (2005) Induction of tumor NK-cell immunity by anti-CD69 antibody therapy. Blood 105: 4399-4406.
46. Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, et al. (2012) CD69 Regulates Type I IFN-Induced Tolerogenic Signals to Mucosal CD4 T Cells That Attenuate Their Colitogenic Potential. J Immunol 188: 2001-2013.
47. Cooper HS, Murthy SN, Shah RS, Sedergran DJ, (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69: 238-249.
48. Ajuebor MN, Das AM, Virag L, Flower RJ, Szabo C, et al. (1999) Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. J Immunol 162: 1685-1691.
49. Nigo YI, Yamashita M, Hirahara K, Shinnakasu R, Inami M, et al. (2006) Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc Natl Acad Sci U S A 103: 2286-2291.
50. Nakayama T, June CH, Munitz TI, Sheard M, McCarthy SA, et al. (1990) Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science 249: 1558-1561.
51. Yamashita M, Kimura M, Kubo M, Shimizu C, Tada T, et al. (1999) T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation. Proc Natl Acad Sci U S A 96: 1024-1029.
52. Hasegawa A, Miki T, Hosokawa H, Hossain MB, Shimizu C, et al. (2006) Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. J Immunol 176: 2546-2554.