Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the european prospective investigation into cancer and nutrition (EPIC) study

Carcinogenesis

Volumn 34, Issue 6, 2013, Pages 1244-1250

  Agudo, Antonio ^a   Bonet, Catalina ^a   Sala, Núria ^a   Muñoz, Xavier ^a   Aranda, Núria ^b   Fonseca Nunes, Ana ^a   Clavel Chapelon, Françoise ^c,d   Boutron Ruault, Marie Christine ^c,d   Vineis, Paolo ^e,f   Panico, Salvatore ^g   Palli, Domenico ^h   Tumino, Rosario ⁱ   Grioni, Sara ^j   Ramon Quiros J ^k   Molina, Esther ^l,m   Navarro, Carmen ^m,n   Barricarte, Aurelio ^m,o   Chamosa, Saioa ^p   Allen, Naomi E ^q,r   Khaw, Kay Tee ^s   Bas Bueno de Mesquita, H ^t,u   Siersema, Peter D ^u   Numans, Mattijs E ^u,v   Trichopoulou, Antonia ^w,x   Lagiou, Pagona ^w,y,z   Trichopoulos, Dimitrios ^x,y   Kaaks, Rudof ^aa   Canzian, Federico ^aa   Boeing, Heiner ^ab   Meidtner, Karina ^ab   Johansson, Mattias ^ac,ad   Sund, Malin ^ac   Manjer, Jonas ^ae   Overvad, Kim ^af   Tjonneland, Anne ^ag   Lund, Eiliv ^ah   Weiderpass, Elisabete ^ah   Jenab, Mazda ^ad   Fedirko, Veronika ^ad   Offerhaus, G Johan A ^u   Riboli, Elio ^e   González, Carlos A ^a   Jakszyn, Paula ^a   more..

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f HuGeF Foundation   (Italy)

^g UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^h CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

ⁱ Cancer Registry and Histopathology Unit   (Italy)

^j NATIONAL CANCER INSTITUTE   (Italy)

^k Public Health Directorate Asturias   (Spain)

^l ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^m CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

ⁿ Regional Health Authority   (Spain)

^o INSTITUTO DE SALUD PÚBLICA DE NAVARRA   (Spain)

^p BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

^q UNIVERSITY OF OXFORD   (United Kingdom)

^r UNIVERSITY OF OXFORD   (United Kingdom)

^s UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^t NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^u UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^v VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^w UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^x HELLENIC HEALTH FOUNDATION   (Greece)

^y HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^z BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^aa GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^ab GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^ac UMEÅ UNIVERSITY   (Sweden)

^ad INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^ae LUND UNIVERSITY HOSPITAL   (Sweden)

^af AARHUS UNIVERSITY   (Denmark)

^ag INSTITUTE OF CANCER EPIDEMIOLOGY   (Denmark)

^ah UNIVERSITY OF TROMSØ   (Norway)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER INCIDENCE; CANCER RISK; CONTROLLED STUDY; EUROPE; FEMALE; GENE; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HEMOCHROMATOSIS; HEREDITARY HEMOCHROMATOSIS; HFE GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH CANCER;

ADENOCARCINOMA; CARDIA; CASE-CONTROL STUDIES; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEMOCHROMATOSIS; HUMANS; MALE; MIDDLE AGED; MUTATION; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK; STOMACH NEOPLASMS;

EID: 84878972815     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt045     Document Type: Article

References (33)

1. González,C.A. et al. (2006) Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation into Cancer and Nutrition (EPIC). J. Natl. Cancer Inst., 98, 345-354.
2. Jakszyn,P. et al. (2006) Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis, 27, 1497-1501.
3. Jakszyn,P. et al. (2012) Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. Int. J. Cancer, 130, 2654-2663.
4. Edgren,G. et al. (2008) Cancer as a ferrotoxic disease: are we getting hard stainless evidence?. J. Natl. Cancer Inst., 100, 976-977.
5. Toyokuni,S. (2009) Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci., 100, 9-16.
6. Lunn,J.C. et al. (2007) The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract. Carcinogenesis, 28, 685-690.
7. Neff,L.M. (2003) Current directions in hemochromatosis research: towards an understanding of the role of iron overload and the HFE gene mutations in the development of clinical disease. Nutr. Rev., 61, 38-42.
8. Worwood,M. (2005) Inherited iron loading: genetic testing in diagnosis and management. Blood Rev., 19, 69-88.
9. Steinberg,K.K. et al. (2001) Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. JAMA, 285, 2216-2222.
10. Ellervik,C. et al. (2007) Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls. Hepatology, 46, 1071-1080.
11. Jin,F. et al. (2010) Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a metaanalysis. J. Exp. Clin. Cancer Res., 29, 18.
12. Osborne,N.J. et al. (2010) HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology, 51, 1311-1318.
13. Shaheen,N.J. et al. (2003) Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. J. Natl. Cancer Inst., 95, 154-159.
14. Robinson,J.P. et al. (2005) Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer. Cancer Epidemiol. Biomarkers Prev., 14, 1460-1463.
15. van der, A,D.L. et al. (2003) Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands). Canc. Causes Contr., 14, 541-545.
16. Ekblom,K. et al. (2012) Iron biomarkers in plasma, HFE genotypes, and the risk for colorectal cancer in a prospective setting. Dis. Colon Rectum, 55, 337-344.
17. Chan,A.T. et al. (2005) Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. J. Natl. Cancer Inst., 97, 917-926.
18. Gannon,P.O. et al. (2011) Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis. Int. J. Cancer, 128, 2326-2334.
19. Syrjäkoski,K. et al. (2006) Hemochromatosis gene mutations among Finnish male breast and prostate cancer patients. Int. J. Cancer, 118, 518-520.
20. Hucl,T. et al. (2007) HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma. Genet. Med., 9, 479-483.
21. Viola,A. et al. (2006) HFE gene mutations in patients with acute leukemia. Leuk. Lymphoma, 47, 2331-2334.
22. Riboli,E. et al. (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr., 5, 1113-1124.
23. Carneiro,F. et al. (2007) Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC/EUR-GAST). Scand. J. Gastroenterol., 42, 618-627.
24. Sala,N. et al. (2012) Prostate stem-cell antigen gene is associated with diffuse and intestinal gastric cancer in Caucasians: results from the EPICEURGAST study. Int. J. Cancer, 130, 2417-2427.
25. Agudo,A. et al. (2006) Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol. Biomarkers Prev., 15, 2427-2434.
26. Dorak,M.T. (2006) HFE H63D variant and leukemia susceptibility. Leuk. Lymphoma, 47, 2269-2270.
27. Dockray,G.J. et al. (2001) The gastrins: their production and biological activities. Annu. Rev. Physiol., 63, 119-139.
28. Rembiasz,K. et al. (2005) Biomarkers in various types of atrophic gastritis and their diagnostic usefulness. Dig. Dis. Sci., 50, 474-482.
29. Agréus,L. et al. (2012) Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. Scand. J. Gastroenterol., 47, 136-147.
30. Smith,K.A. et al. (2006) Circulating gastrin is increased in hemochromatosis. FEBS Lett., 580, 6195-6198.
31. González,C.A. et al. (2012) Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project. Ann. Oncol., 23, 1320-1324.
32. Andrews,N.C. et al. (2007) Iron homeostasis. Annu. Rev. Physiol., 69, 69-85.
33. Davis,C.F. et al. (2010) An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia. Ann. Hematol., 89, 375-384.