Metallomics for drug development: Serum protein binding and analysis of an anticancer tris(8-quinolinolato)gallium(III) drug using inductively coupled plasma mass spectrometry

Analytica Chimica Acta

Volumn 785, Issue , 2013, Pages 22-26

  Ossipov, Konstantin ^a   Foteeva, Lidia S ^b   Seregina, Irina F ^a   Perevalov, Sergei A ^b   Timerbaev, Andrei R ^b   Bolshov, Mikhail A ^a,c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b VERNADSKY INSTITUTE OF GEOCHEMISTRY AND ANALYTICAL CHEMISTRY   (Russian Federation)

^c INSTITUTE OF SPECTROSCOPY   (Russian Federation)

Author keywords

Anticancer metallodrugs; Inductively coupled plasma mass spectrometry; Serum proteins

Indexed keywords

ANTICANCER METALLODRUGS; ASSOCIATION CONSTANT; DRUG DEVELOPMENT; EQUILIBRIUM STATE; INDIVIDUAL PROTEINS; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRIES (ICPMS); QUANTITATIVE BINDING; SERUM PROTEINS;

BIOCHEMISTRY; BODY FLUIDS; MASS SPECTROMETERS; PROTEINS;

INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY;

ALBUMIN; ANTINEOPLASTIC AGENT; TRANSFERRIN; TRIS(8 QUINOLINOLATO)GALLIUM; UNCLASSIFIED DRUG;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BINDING AFFINITY; BIOMICS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TRANSFORMATION; FEMALE; HUMAN; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; METALLOMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; REPRODUCIBILITY; SENSITIVITY ANALYSIS; TRANSFERRIN BLOOD LEVEL;

ANTINEOPLASTIC AGENTS; BLOOD PROTEINS; HUMANS; KINETICS; MASS SPECTROMETRY; ORGANOMETALLIC COMPOUNDS; OXYQUINOLINE; PROTEIN BINDING; SERUM ALBUMIN; TRANSFERRIN;

EID: 84878970733     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2013.05.004     Document Type: Article

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