Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice

NPG Asia Materials

Volumn 5, Issue 4, 2013, Pages

  Li, Bo ^a,b   Yang, Jianzhong ^a   Huang, Qing ^a   Zhang, Yi ^a   Peng, Cheng ^a   Zhang, Yujie ^a   He, Yao ^a,c   Shi, Jiye ^a,d   Li, Wenxin ^a   Hu, Jun ^a   Fan, Chunhai ^a  

^a SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^b Jilin University   (China)

^c SOOCHOW UNIVERSITY   (China)

^d UCB PHARMA   (Belgium)

Author keywords

Biodistribution; Graphene oxide; Intratracheal instillation; Mice; Pulmonary toxicity

Indexed keywords

BIODISTRIBUTIONS; GRAPHENE OXIDES; INTRATRACHEAL INSTILLATION; MICE; PULMONARY TOXICITY;

BIOLOGICAL ORGANS; GRAPHENE; MAMMALS; RADIOISOTOPES;

TOXICITY;

EID: 84878970064     PISSN: 18844049     EISSN: 18844057     Source Type: Journal    
DOI: 10.1038/am.2013.7     Document Type: Article

References (30)

1. Novoselov, K. S., Geim, A. K., Morozov, S. V., Jiang, D., Zhang, Y., Dubonos, S. V., Grigorieva, I. V. & Firsov, A. A. Electric field effect in atomically thin carbon films. Science 306, 666-669 (2004).
2. Gong, S., Yang, C. & Qin, J. Efficient phosphorescent polymer light-emitting diodes by suppressing triplet energy back transfer. Chem. Soc. Rev. 41, 4797-4807 (2012).
3. Zhang, Y., Nayak, T. R., Hong, H. & Cai, W. Graphene: a versatile nanoplatform for biomedical applications. Nanoscale 4, 3833-3842 (2012).
4. Feng, L. & Liu, Z. Graphene in biomedicine: opportunities and challenges. Nanomedicine (Lond) 6, 317-324 (2011).
5. Rogueda, P. G. A. & Traini, D. The nanoscale in pulmonary delivery. Part 1: deposition, fate, toxicology and effects.. Expert. Opin. Drug. Deliv. 4, 595-606 (2007).
6. Kovtyukhova, N. I., Ollivier, P. J., Martin, B. R., Mallouk, T. E., Chizhik, S. A., Buzaneva, E. V. & Gorchinskiy, A. D. Layer-by-layer assembly of ultrathin composite films from micron-sized graphite oxide sheets and polycations. Chem. Mater. 11, 771-778 (1999).
7. Deng, X., Yang, S., Nie, H., Wang, H. & Liu, Y. A generally adoptable radiotracing method for tracking carbon nanotubes in animals. Nanotechnology 19 (2008).
8. Sayes, C. M., Marchione, A. A., Reed, K. L. & Warheit, D. B. Comparative pulmonary toxicity assessments of C-60 water suspensions in rats: few differences in fullerene toxicity in vivo in contrast to in vitro profiles. Nano Lett. 7, 2399-2406 (2007).
9. Oberdorster, G., Oberdorster, E. & Oberdorster, J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113, 823-839 (2005).
10. Gauderman, W. J., Avol, E., Gilliland, F., Vora, H., Thomas, D., Berhane, K., McConnell, R., Kuenzli, N., Lurmann, F., Rappaport, E., Margolis, H., Bates, D. & Peters, J. The effect of air pollution on lung development from 10 to 18 years of age. N. Engl. J. Med. 351, 1057-1067 (2004).
11. Kaiser, J. Combining targeted drugs to stop resistant tumors. Science 331, 1504-1505 (2011).
12. Ruge, C. A., Schaefer, U. F., Herrmann, J., Kirch, J., Canadas, O., Echaide, M., Perez-Gil, J., Casals, C., Muller, R. & Lehr, C. M. The interplay of lung surfactant proteins and lipids assimilates the marcrophage clearance of nanoparticles. PloS One 7, e40775 (2012).
13. Semmler-Behnke, M., Takenaka, S., Fertsch, S., Wenk, A., Seitz, J., Mayer, P., Oberdorster, G. & Kreyling, W. G. Efficient elimination of inhaled nanoparticles from the alveolar region: Evidence for interstitial uptake and subsequent reentrainment onto airway epithelium. Environ. Health Perspect. 115, 728-733 (2007).
14. Shvedova, A. A., Kisin, E. R., Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. I., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., Hubbs, A. F., Antonini, J., Evans, D. E., Ku, B. K., Ramsey, D., Maynard, A., Kagan, V. E., Castranova, V. & Baron, P. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. J. Physiol. Lung Cell. Mol. Physiol. 289, L698-L708 (2005).
15. Abraham, E., Carmody, A., Shenkar, R. & Arcaroli, J. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, L1137-L1145 (2000).
16. Ware, L. B. & Matthay, M. A. Medical progress-the acute respiratory distress syndrome. N. Engl. J. Med. 342, 1334-1349 (2000).
17. Azoulay, E., Darmon, M., Delclaux, C., Fieux, F., Bornstain, C., Moreau, D., Attalah, H., Le Gall, J. R. & Schlemmer, B. Deterioration of previous acute lung injury during neutropenia recovery. Crit. Care Med. 30, 781-786 (2002).
18. Aillon, K. L., Xie, Y., El-Gendy, N., Berkland, C. J. & Forrest, M. L. Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv. Drug. Deliv. Rev. 61, 457-466 (2009).
19. Li, N., Xia, T. & Nel, A. E. The role of oxidative stress in ambient particulate matterinduced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic. Biol. Med. 44, 1689-1699 (2008).
20. Ding, X. M., Duan, Y. Y., Peng, C. S., Feng, H. S., Zhou, P. K., Meng, J. G., Xue, Z. Q. & Xu, Q. Z. Dexamethasone treatment attenuates early seawaters instillation-induced acute lung injury in rabbits. Pharmacol. Res. 53, 372-379 (2006).
21. Nel, A. Air pollution-related illness: effects of particles. Science 308, 804-806 (2005).
22. McCreanor, J., Cullinan, P., Nieuwenhuijsen, M. J., Stewart-Evans, J., Malliarou, E., Jarup, L., Harrington, R., Svartengren, M., Han, I. -K., Ohman-Strickland, P., Chung, K. F. & Zhang, J. Respiratory effects of exposure to diesel traffic in persons with asthma. N. Engl. J. Med. 357, 2348-2358 (2007).
23. Oberdorster, E. Manufactured nanomaterials(Fullerenes, C-60) induce oxidative stress in the brain of juvenile largemouth bass. Environ. Health Perspect. 112, 1058-1062 (2004).
24. Pope, C. A., Ezzati, M. & Dockery, D. W. Fine-particulate air pollution and life expectancy in the United States. N. Engl. J. Med. 360, 376-386 (2009).
25. Brown, J. S., Zeman, K. L. & Bennett, W. D. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am. J. Respir. Crit. Care Med. 166, 1240-1247 (2002).
26. Chalupa, D. C., Morrow, P. E., Oberdorster, G., Utell, M. J. & Frampton, M. W. Ultrafine particle deposition in subjects with asthma. Environ. Health Perspect. 112, 879-882 (2004).
27. Marris., E. The politics of breathing. Nature 444, 248-249 (2006).
28. Brown, D. M., Wilson, M. R., MacNee, W., Stone, V. & Donaldson, K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 175, 191-199 (2001).
29. Yang, K., Li, Y., Tan, X., Peng, R. & Liu, Z. Behavior and toxicity of Graphene and its functionalized derivatives in biological systems. Small (e-pub ahead of print 17 September 2012; doi:10.1002/smll.201201417).
30. Duch, M. C., Budinger, G. R. S., Liang, Y. T., Soberanes, S., Urich, D., Chiarella, S. E., Campochiaro, L. A., Gonzalez, A., Chandel, N. S., Hersam, M. C. & Mutlu, G. M. Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Lett. 11, 5201-5207 (2011).