Pharmaceutical quality of "party pills" raises additional safety concerns in the use of illicit recreational drugs

New Zealand Medical Journal

Volumn 126, Issue 1376, 2013, Pages

  Young, Simon A ^a   Thrimawithana, Thilini R ^a   Antia, Ushtana ^b   Fredatovich, John D ^b   Na, Yonky ^b   Neale, Peter T ^b   Roberts, Amy F ^b   Zhou, Huanyi ^b   Russell, Bruce ^b  

^a RMIT UNIVERSITY   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

$5 PARTY PILL; 1 (3 TRIFLUOROMETHYLPHENYL) PIPERAZINE; 1 BENZYLPIPERAZINE DERIVATIVE; BLUE DIAMONDS; BUZZZ; CRIMSON HEARTS; EFX; EXODUS; EXOTIC; FRENZY; HUMMER; NOS BOOST; PEAQ; RECREATIONAL DRUG; STINGERS XTREME; THE PINKY PANTHER; UNCLASSIFIED DRUG; XOMBIE;

ARTICLE; COMPARATIVE STUDY; DRUG DETERMINATION; DRUG FORMULATION; DRUG INDUSTRY; DRUG PACKAGING; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KINETICS; QUALITY CONTROL; REVERSE OSMOSIS; ROOM TEMPERATURE; TABLET FORMULATION; ULTRAVIOLET SPECTROPHOTOMETRY; VALIDATION PROCESS;

EID: 84878968344     PISSN: 00288446     EISSN: 11758716     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. New Zealand Government. Misuse of Drugs (Classification of BZP) Amendment Act Wellington 2008.
2. Baumann MH, Clark RD, Budzynski AG, Partilla JS, Blough BE, Rothman RB. N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4- Methylenedioxymethamphetamine (MDMA, or 'Ecstasy'). Neuropsychopharmacol. 2005;30(3):550-60.
3. Vollenweider FX, Gamma A, Liechti M, Huber T. Psychological and cardiovascular effects and short-term sequelae of MDMA ('Ecstasy') in MDMA-naive healthy volunteers. Neuropsychopharmacol. 1998;19(4):241-51.
4. Liechti ME, Vollenweider FX. Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies. Hum Psychopharmacol. 2001;16(8):589-98.
5. Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). Pharmacol Rev. 2003;55(3):463-508.
6. Morgan MJ. Memory deficits associated with recreational use of 'ecstasy' (MDMA). Psychopharmacology. 1999;141(1):30-6.
7. Morgan MJ, Impallomeni LC, Pirona A, Rogers RD. Elevated impulsivity and impaired decision-making in abstinent ecstasy (MDMA) users compared to polydrug and drug-naïve controls. Neuropsychopharmacol. 2006;31(7):1562-73.
8. Tekes K, Tóthfalusi L, Malomvölgyi B, Hermán F, Magyar K. Studies on the biochemical mode of action of EGYT-475, a new antidepressant. Pol J Pharmacol Pharm. 1987;39(2):203-11.
9. Lin JC, Bangs N, Lee H, Kydd RR, Russell BR. Determining the subjective and physiological effects of BZP on human females. Psychopharmacology. 2009;207(3):439-46.
10. Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR. Pharmacokinetics of 'party pill' drug N- benzylpiperazine (BZP) in healthy human participants. Forensic Science International. 2009;186(1-3):63-7.
11. Antia U, Tingle MD, Russell BR. Validation of an LC-MS method for the detection and quantification of BZP and TFMPP and their hydroxylated metabolites in human plasma and its application to the pharmacokinetic study of TFMPP in humans. Journal of Forensic Sciences. 2010;55(5):1311-8.
12. Staack RF, Maurer HH. Metabolism of designer drugs of abuse. Curr Drug Metab. 2005;6(3):259-74.
13. Jan RK, Lin JC, Lee H, Sheridan JL, Kydd RR, Kirk IJ, et al. Determining the subjective effects of TFMPP in human males. Psychopharmacology. 2010;211(3):347-53.
14. Thompson I, Williams G, Aldington S, Williams M, Caldwell B, Dickson S, et al. The benzylpiperazine (BZP)/trifluoromethylphenylpiperazine (TFMPP) and alcohol safety study. Wellington: Medical Research Institute of New Zealand 2006.
15. Antia U, Tingle MD, Russell BR. 'Party pill' drugs - BZP and TFMPP (New Zealand Medical Journal (2009) 122, 1307). New Zealand Medical Journal. 2010;123(1316):139.
16. Gee P, Richardson S, Woltersdorf W, Moore G. Toxic effects of BZP-based herbal party pills in humans: A prospective study in Christchurch, New Zealand. New Zealand Medical Journal. 2005;118(1227).
17. Lin JC, Jan RK, Lee H, Jensen MA, Kydd RR, Russell BR. Determining the subjective and physiological effects of BZP combined with TFMPP in human males. Psychopharmacology. 2011;214(3):761-8.