A role for Myh1 in DNA repair after treatment with strand-breaking and crosslinking chemotherapeutic agents

Environmental and Molecular Mutagenesis

Volumn 54, Issue 5, 2013, Pages 327-337

  Jansson, Kristina ^a   Alao, John P ^a   Viktorsson, Kristina ^b   Warringer, Jonas ^a   Lewensohn, Rolf ^b   Sunnerhagen, Per ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

9 1 1 complex; Base excision repair; Bleomycin; Cisplatin; DNA glycosylase; Mismatch repair

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CISPLATIN; DNA GLYCOSYLASE MUTY; HYDROGEN PEROXIDE; PHLEOMYCIN; PLATINUM DERIVATIVE;

ARTICLE; CHEMOTHERAPY; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENOTOXICITY; NONHUMAN; SURVIVAL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CISPLATIN; CROSS-LINKING REAGENTS; DNA GLYCOSYLASES; DNA REPAIR; DNA, FUNGAL; FLUORESCENT ANTIBODY TECHNIQUE; GENE DELETION; MICROBIAL VIABILITY; MICROSCOPY, FLUORESCENCE; ORGANOPLATINUM COMPOUNDS; PHLEOMYCINS; SCHIZOSACCHAROMYCES POMBE PROTEINS;

SCHIZOSACCHAROMYCES POMBE;

EID: 84878950656     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21784     Document Type: Article

References (46)

1. Alao JP, Huis in't Veld PJ, Buhse F, Sunnerhagen P. 2010. Hyperosmosis enhances radiation and hydroxyurea resistance of S. pombe checkpoint mutants through the spindle checkpoint and delayed cytokinesis. Mol Microbiol 77:143-157.
2. Bai H, Lu AL. 2007. Physical and functional interactions between Escherichia coli MutY glycosylase and mismatch repair protein MutS. J Bacteriol 189:902-910.
3. Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A. 2003. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci USA 100:1633-1638.
4. Bähler J, Wu JQ, Longtine MS, Shah NG, McKenzie A 3rd, Steever AB, Wach A, Philippsen P, Pringle JR. 1998. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14:943-951.
5. Campalans A, Amouroux R, Bravard A, Epe B, Radicella JP. 2007. UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles. J Cell Sci 120:23-32.
6. Chang DY, Lu AL. 2005. Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe. J Biol Chem 280:408-417.
7. Chang DY, Gu Y, Lu AL. 2001. Fission yeast (Schizosaccharomyces pombe) cells defective in the MutY-homologous glycosylase activity have a mutator phenotype and are sensitive to hydrogen peroxide. Mol Genet Genomics 266:336-342.
8. Chang DY, Shi G, Durand-Dubief M, Ekwall K, Lu AL. 2011. The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe. J Mol Biol 405:653-665.
9. Chen J, Stubbe J. 2005. Bleomycins: Towards better therapeutics. Nat Rev Cancer 5:102-112.
10. Chmiel NH, Golinelli MP, Francis AW, David SS. 2001. Efficient recognition of substrates and substrate analogs by the adenine glycosylase MutY requires the C-terminal domain. Nucl Acids Res 29:553-564.
11. Dedon PC, Plastaras JP, Rouzer CA, Marnett LJ. 1998. Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proc Natl Acad Sci USA 95:11113-11116.
12. Denver DR, Swenson SL, Lynch M. 2003. An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases. Mol Biol Evol 20:1603-1611.
13. Desoize B, Madoulet C. 2002. Particular aspects of platinum compounds used at present in cancer treatment. Crit Rev Oncol Hematol 42:317-325.
14. Doi T, Yonekura S, Tano K, Yasuhira S, Yonei S, Zhang QM. 2005. The Schizosaccharomyces pombe homolog (SpMYH) of the Escherichia coli MutY is required for removal of guanine from 8-oxoguanine/guanine mispairs to prevent G:C to C:G transversions. J Radiat Res 46:205-214.
15. Einhorn LH. 2002. Curing metastatic testicular cancer. Proc Natl Acad Sci USA 99:4592-4595.
16. Ferry KV, Fink D, Johnson SW, Nebel S, Hamilton TC, Howell SB. 1999. Decreased cisplatin damage-dependent DNA synthesis in cellular extracts of mismatch repair deficient cells. Biochem Pharmacol 57:861-867.
17. Flores-Rozas H, Clark D, Kolodner RD. 2000. Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex. Nat Genet 26:375-378.
18. Friedrich-Heineken E, Toueille M, Tannler B, Burki C, Ferrari E, Hottiger MO, Hubscher U. 2005. The two DNA clamps Rad9/Rad1/Hus1 complex and proliferating cell nuclear antigen differentially regulate flap endonuclease 1 activity. J Mol Biol 353:980-989.
19. Gu Y, Parker A, Wilson TM, Bai H, Chang DY, Lu AL. 2002. Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J Biol Chem 277:11135-11142.
20. Helt CE, Wang W, Keng PC, Bambara RA. 2005. Evidence that DNA damage detection machinery participates in DNA repair. Cell Cycle 4:529-532.
21. +. Mutat Res 644:48-55.
22. Jansson K, Blomberg A, Sunnerhagen P, Alm-Rosenblad M. 2010. Evolutionary loss of 8-oxo-G repair components among eukaryotes. Genome Integr 1:12.
23. Jones S, Emmerson P, Maynard J, Best JM, Jordan S, Williams GT, Sampson JR, Cheadle JP. 2002. Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C->T:A mutations. Hum Mol Genet 11:2961-2967.
24. Jones S, Lambert S, Williams GT, Best JM, Sampson JR, Cheadle JP. 2004. Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas. Br J Cancer 90:1591-1593.
25. Kearsey SE, Montgomery S, Labib K, Lindner K. 2000. Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. EMBO J 19:1681-1690.
26. Kim M, Huang T, Miller JH. 2003. Competition between MutY and mismatch repair at A x C mispairs in vivo. J Bacteriol 185:4626-4629.
27. Kryston TB, Georgiev AB, Pissis P, Georgakilas AG. 2011. Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711:193-201.
28. Li X, Wright PM, Lu AL. 2000. The C-terminal domain of MutY glycosylase determines the 7, 8-dihydro-8-oxo-guanine specificity and is crucial for mutation avoidance. J Biol Chem 275:8448-8455.
29. Lipton L, Halford SE, Johnson V, Novelli MR, Jones A, Cummings C, Barclay E, Sieber O, Sadat A, Bisgaard ML, Hodgson SV, Aaltonen LA, Thomas HJ, Tomlinson IP. 2003. Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway. Cancer Res 63:7595-7599.
30. Lu AL, Fawcett WP. 1998. Characterization of the recombinant MutY homolog, an adenine DNA glycosylase, from yeast Schizosaccharomyces pombe. J Biol Chem 273:25098-25105.
31. Moore CW. 1988. Internucleosomal cleavage and chromosomal degradation by bleomycin and phleomycin in yeast. Cancer Res 48:6837-6843.
32. Moreno S, Klar A, Nurse P. 1991. Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe. Meth Enzymol 194:795-823.
33. Parker A, Gu Y, Mahoney W, Lee SH, Singh KK, Lu AL. 2001. Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair. J Biol Chem 276:5547-5555.
34. Sampson JR, Dolwani S, Jones S, Eccles D, Ellis A, Evans DG, Frayling I, Jordan S, Maher ER, Mak T, Maynard J, Pigatto F, Shaw J, Cheadle JP. 2003. Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. Lancet 362:39-41.
35. Sherman F. 1991. Getting started with yeast. Meth Enzymol 194:3-21.
36. Shi G, Chang DY, Cheng CC, Guan X, Venclovas C, Lu AL. 2006. Physical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1. Biochem J 400:53-62.
37. Sugiura Y, Kikuchi T. 1978. Formation of superoxide and hydroxy radicals in iron(II)-bleomycin-oxygen system: Electron spin resonance detection by spin trapping. J Antibiot 31:1310-1312.
38. Toueille M, El-Andaloussi N, Frouin I, Freire R, Funk D, Shevelev I, Friedrich-Heineken E, Villani G, Hottiger MO, Hubscher U. 2004. The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: Implications for DNA repair. Nucl Acids Res 32:3316-3324.
39. Warringer J, Blomberg A. 2003. Automated screening in environmental arrays allows analysis of quantitative phenotypic profiles in Saccharomyces cerevisiae. Yeast 20:53-67.
40. Warringer J, Zörgö E, Cubillos FA, Zia A, Gjuvsland A, Simpson JT, Forsmark A, Durbin R, Omholt SW, Louis EJ, Liti G, Moses A, Blomberg A. 2011. Trait variation in yeast is defined by population history. PLoS Genet 7:e1002111.
41. Wilson DM 3rd, Sofinowski TM, McNeill DR. 2003. Repair mechanisms for oxidative DNA damage. Front Biosci 8:963-981.
42. Woynarowski JM, Faivre S, Herzig MC, Arnett B, Chapman WG, Trevino AV, Raymond E, Chaney SG, Vaisman A, Varchenko M, Juniewicz PE. 2000. Oxaliplatin-induced damage of cellular DNA. Mol Pharmacol 58:920-927.
43. Yamada M, O'Regan E, Brown R, Karran P. 1997. Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins. Nucl Acids Res 25:491-496.
44. Yarema KJ, Wilson JM, Lippard SJ, Essigmann JM. 1994. Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs. J Mol Biol 236:1034-1048.
45. Yarema KJ, Lippard SJ, Essigmann JM. 1995. Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II). Nucl Acids Res 23:4066-4072.
46. Zharkov DO, Grollman AP. 1998. MutY DNA glycosylase: Base release and intermediate complex formation. Biochemistry 37:12384-12394.