The LuxR family regulator Rv0195 modulates Mycobacterium tuberculosis dormancy and virulence

Tuberculosis

Volumn 93, Issue 4, 2013, Pages 425-431

  Fang, Haihong ^a   Yu, Dan ^a   Hong, Yuzhi ^a   Zhou, Xiaodan ^a   Li, Chuanyou ^b   Sun, Baolin ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Tuberculosis Mycobacterium tuberculosis Dormancy LuxR family transcription factor Virulence

Indexed keywords

ASCORBIC ACID; TRANSCRIPTION FACTOR LUXR;

AEROBIC METABOLISM; ANAEROBIC GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CELL SURVIVAL; DORMANCY; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN CELL; HYBRIDIZATION; HYPOXIA; MACROPHAGE; MICROARRAY ANALYSIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; STRESS; SURVIVAL; TUBERCULOSIS; UPREGULATION;

ANIMALS; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HUMANS; LATENT TUBERCULOSIS; MACROPHAGES; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUBERCULOSIS; VIRULENCE; VIRUS REPLICATION;

EID: 84878938296     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/j.tube.2013.04.005     Document Type: Article

References (34)

1. C. Dye, S. Scheele, P. Dolin, V. Pathania, and M.C. Raviglione Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country J Am Med Assoc 282 1999 677 686
2. J.L. Flynn, and J. Chan Immunology of tuberculosis Annu Rev Immunol 19 2001 93 129 10.1146/annurev.immunol.19.1.93
3. L.G. Wayne, and L.G. Hayes An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence Infect Immun 64 1996 2062 2069
4. S. Hussain, M. Malik, L. Shi, M.L. Gennaro, and K. Drlica In vitro model of mycobacterial growth arrest using nitric oxide with limited air Antimicrobial Agents Chemother 53 2009 157 161 10.1128/AAC.00442-08
5. D.R. Sherman, M. Voskuil, D. Schnappinger, R. Liao, M.I. Harrell, and G.K. Schoolnik Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin Proc Natl Acad Sci USA 98 2001 7534 7539 10.1073/pnas.121172498
6. N. Dasgupta, V. Kapur, K.K. Singh, T.K. Das, S. Sachdeva, K. Jyothisri, and J.S. Tyagi Characterization of a two-component system, devR-devS, of Mycobacterium tuberculosis Tuber Lung Dis 80 2000 141 159
7. T.R. Rustad, M.I. Harrell, R. Liao, and D.R. Sherman The enduring hypoxic response of Mycobacterium tuberculosis PloS One 3 2008 e1502 10.1371/journal.pone.0001502
8. M.I. Voskuil, D. Schnappinger, K.C. Visconti, M.I. Harrell, G.M. Dolganov, D.R. Sherman, and G.K. Schoolnik Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program J Exp Med 198 2003 705 713 10.1084/jem.20030205
9. N.K. Taneja, S. Dhingra, A. Mittal, M. Naresh, and J.S. Tyagi Mycobacterium tuberculosis transcriptional adaptation, growth arrest and dormancy phenotype development is triggered by vitamin C PloS One 5 2010 e10860 10.1371/journal.pone.0010860
10. R.L. Leistikow, R.A. Morton, I.L. Bartek, I. Frimpong, K. Wagner, and M.I. Voskuil The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy J Bacteriol 192 2010 1662 1670 10.1128/JB.00926-09
11. A. Kumar, J.S. Deshane, D.K. Crossman, S. Bolisetty, B.S. Yan, I. Kramnik, A. Agarwal, and A.J. Steyn Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon J Biol Chem 283 2008 18032 18039 10.1074/jbc.M802274200
12. D. Schnappinger, S. Ehrt, M.I. Voskuil, Y. Liu, J.A. Mangan, I.M. Monahan, G. Dolganov, B. Efron, P.D. Butcher, C. Nathan, and G.K. Schoolnik Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment J Exp Med 198 2003 693 704 10.1084/jem.20030846
13. P.C. Karakousis, T. Yoshimatsu, G. Lamichhane, S.C. Woolwine, E.L. Nuermberger, J. Grosset, and W.R. Bishai Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice J Exp Med 200 2004 647 657 10.1084/jem.20040646
14. D. Sharma, A. Bose, H. Shakila, T.K. Das, J.S. Tyagi, and V.D. Ramanathan Expression of mycobacterial cell division protein, FtsZ, and dormancy proteins, DevR and Acr, within lung granulomas throughout guinea pig infection FEMS Immunol Med Microbiol 48 2006 329 336 10.1111/j.1574-695X.2006.00160.x
15. V. Malhotra, J.S. Tyagi, and J.E. Clark-Curtiss DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism Tuberculosis 89 2009 169 174
16. K. Minch, T. Rustad, and D.R. Sherman Mycobacterium tuberculosis growth following aerobic expression of the DosR regulon PloS One 7 2012 e35935 10.1371/journal.pone.0035935
17. A.J. Pompeani, J.J. Irgon, M.F. Berger, M.L. Bulyk, N.S. Wingreen, and B.L. Bassler The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters Mol Microbiol 70 2008 76 88 10.1111/j.1365-2958.2008.06389.x
18. H. Withers, S. Swift, and P. Williams Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria Curr Opin Microbiol 4 2001 186 193
19. N.A. Whitehead, A.M. Barnard, H. Slater, N.J. Simpson, and G.P. Salmond Quorum-sensing in Gram-negative bacteria FEMS Microbiol Rev 25 2001 365 404
20. W.R. Galloway, J.T. Hodgkinson, S.D. Bowden, M. Welch, and D.R. Spring Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways Chem Rev 111 2011 28 67 10.1021/cr100109t
21. S. Subramoni, and V. Venturi LuxR-family 'solos': bachelor sensors/regulators of signalling molecules Microbiology 155 2009 1377 1385 10.1099/mic.0.026849-0
22. L.R. Zeng, and J.P. Xie Molecular basis underlying LuxR family transcription factors and function diversity and implications for novel antibiotic drug targets J Cell Biochem 112 2011 3079 3084 10.1002/jcb.23262
23. N. Agarwal, G. Lamichhane, R. Gupta, S. Nolan, and W.R. Bishai Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase Nature 460 2009 98 102 10.1038/nature08123
24. T. Parish, and N.G. Stoker Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement Microbiology 146 2000 1969 1975
25. T. Parish, and N.G. Stoker Mycobacterium tuberculosis protocols 2000 Humana Press Inc. Totowa, NJ 77 92
26. P.J. Converse, P.C. Karakousis, L.G. Klinkenberg, A.K. Kesavan, L.H. Ly, S.S. Allen, J.H. Grosset, S.K. Jain, G. Lamichhane, Y.C. Manabe, D.N. McMurray, E.L. Nuermberger, and W.R. Bishai Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models Infect Immun 77 2009 1230 1237 10.1128/IAI.01117-08
27. T. Parish, D.A. Smith, S. Kendall, W. Casali, G.J. Bancroft, and N.G. Stoker Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis Infect Immun 71 2003 1134 1140
28. L.G. Wayne, and C.D. Sohaskey Nonreplicating persistence of Mycobacterium tuberculosis Annu Rev Microbiol 55 2001 139 163 10.1146/annurev.micro.55.1.139
29. J.B. Andersen, A. Heydorn, M. Hentzer, L. Eberl, O. Geisenberger, B.B. Christensen, S. Molin, and M. Givskov GFP-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication Appl Environ Microbiol 67 2001 575 585 10.1128/AEM.67.2.575-585.2001
30. P.V. Krasteva, J.C.N. Fong, N.J. Shikuma, S. Beyhan, M.V.A.S. Navarro, F.H. Yildiz, and H. Sondermann Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP Science 327 2010 866 868
31. E. Iona, M. Pardini, M.G. Gagliardi, M. Colone, A.R. Stringaro, R. Teloni, L. Brunori, R. Nisini, L. Fattorini, and F. Giannoni Infection of human THP-1 cells with dormant Mycobacterium tuberculosis Microbes Infect 14 2012 959 967
32. N. Kapoor, S. Pawar, T.D. Sirakova, C. Deb, W.L. Warren, and P.E. Kolattukudy Human granuloma in vitro model, for TB dormancy and resuscitation PloS One 8 2013 e53657
33. A.J. Lenaerts, D. Hoff, S. Aly, S. Ehlers, K. Andries, L. Cantarero, I.M. Orme, and R.J. Basaraba Location of persisting mycobacteria in a guinea pig model of tuberculosis revealed by R207910 Antimicrobial Agents Chemother 51 2007 3338 3345 10.1128/AAC.00276-07
34. L.E. Via, P.L. Lin, S.M. Ray, J. Carrillo, S.S. Allen, S.Y. Eum, K. Taylor, E. Klein, U. Manjunatha, J. Gonzales, E.G. Lee, S.K. Park, J.A. Raleigh, S.N. Cho, D.N. McMurray, J.L. Flynn, and C.E. Barry Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates Infect Immun 76 2008 2333 2340 10.1128/IAI.01515-07