The effects of hematological parameters and tumor-infiltrating lymphocytes on prognosis in patients with gastric cancer

Cancer Biomarkers

Volumn 13, Issue 1, 2013, Pages 11-20

  Dirican, Ahmet ^a   Ekinci, Nese ^a   Avci, Arzu ^a   Akyol, Murat ^a   Alacacioglu, Ahmet ^a   Kucukzeybek, Yuksel ^a   Somali, Isil ^a   Erten, Cigdem ^a   Demir, Lutfiye ^a   Can, Alper ^a   Bayoglu, Ibrahim Vedat ^a   Koyuncu, Betul ^a   Ulger, Eda ^a   Tarhan, Mustafa Oktay ^a  

^a IZMIR KATIP CELEBI UNIVERSITY   (Turkey)

Author keywords

Gastric cancer; neutrophil lymphocyte ratio; prognosis; tumor infiltrating lymphocytes

Indexed keywords

CISPLATIN; DOCETAXEL; FLUOROURACIL; FOLINATE CALCIUM; IRINOTECAN;

ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CD4 LYMPHOCYTE COUNT; CELL DENSITY; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL COUNT; OVERALL SURVIVAL; PRIORITY JOURNAL; REFERENCE VALUE; STOMACH ADENOCARCINOMA; STOMACH CANCER; TUMOR ASSOCIATED LEUKOCYTE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; NEUTROPHILS; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS;

EID: 84878932717     PISSN: 15740153     EISSN: 18758592     Source Type: Journal    
DOI: 10.3233/CBM-130331     Document Type: Article

References (42)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005 55: 74-108.
2. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, et al. Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med 1999; 159: 857-863.
3. Dionigi R, Dominioni L, Benevento A, Giudice G, Cuffari S, Bordone N et al. Effects of surgical trauma of laparoscopic vs. open cholecystectomy. Hepatogastroenterology 1994; 41: 471-476.
4. O'Mahony JB, Palder SB,Wood JJ, McIrvine A, Rodrick ML, Demling RH et al. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 1984; 24: 869-875.
5. Zahorec R. Ratio of neutrophil to lymphocyte counts-Rapid andsimple parameter of systemic inflammation and stress in criticallyill. Bratisl Lek Listy 2001; 102: 5-14.
6. Wang S, Zhang Z, Fang F, Gao X, Sun W, Liu H. The neutrophil/lymphocyte ratio is an independent prognostic indicator in patients with bone metastasis. Oncol Lett. 2011 Jul; 2(4): 735-740. Epub 2011 May 13.
7. Cedrés S, Torrejon D, Martínez A, Martinez P, Navarro A, Zamora E, et al. Neutrophil to lymphocyte ratio (NLR) as an indicator of poor prognosis in stage IV non-small cell lung cancer. Clin Transl Oncol. 2012 Jul 19.
8. Ishizuka M, Nagata H, Takagi K, Iwasaki Y, Shibuya N, Kubota K. Clinical Significance of Tumor Pathology for Postoperative Survival of Patients Undergoing Surgery for Stage IV Colorectal Cancer. Anticancer Res. 2012 Aug; 32(8): 3291-7.
9. Proctor MJ, McMillan DC, Morrison DS, Fletcher CD, Horgan PG, Clarke SJ.A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer. 2012 Jul 24. doi: 10.1038/bjc.2012.292.
10. Ma JP, Wang Z, Lin JW, Wu KM, Chen JH, Chen CQ, et al. Neutrophil-lymphocyte ratio as a prognostic factor in gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi 2011 Dec; 14(12):944-7. Chinese.
11. Aizawa M, Gotohda N, Takahashi S, Konishi M, Kinoshita T. Predictive value of baseline neutrophil/lymphocyte ratio for T4 disease in wall-penetrating gastric cancer. World J Surg. 2011 Dec; 35(12): 2717-22.
12. Jung MR, Park YK, Jeong O, Seon JW, Ryu SY, Kim DY et al. Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol. 2011 Oct; 104(5): 504-10. doi: 10.1002/jso.21986. Epub 2011 May 25.
13. Ubukata H, Motohashi G, Tabuchi T, Nagata H, Konishi S, Tabuchi T. Evaluations of interferon-γ/interleukin-4 ratio and neutrophil/lymphocyte ratio as prognostic indicators in gastric cancer patients. J Surg Oncol. 2010 Dec 1; 102(7): 742-7.
14. Shimada H, Takiguchi N, Kainuma O, Soda H, Ikeda A, Cho A et al. High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer. 2010 Aug; 13(3): 170-6. Epub 2010 Sep.
15. Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology. 2007; 73(3-4): 215-20.
16. Lee HE, Chae SW, Lee YJ, Kim MA, Lee HS, Lee BL, et al. Prognostic implications of type and density of tumourinfiltrating lymphocytes in gastric cancer. Br J Cancer. 2008 Nov 18; 99(10): 1704-11. Epub 2008 Oct 21.
17. Nosho K, Baba Y, Tanaka N, Shima K, Hayashi M, Meyerhardt JA, et al. Tumour-infiltrating T-cell subsets molecular changes in colorectal cancer, and prognosis: cohort study and literature review. J Pathol. 2010 Dec; 222(4): 350-66. Review.
18. Clemente CG, Mihm MC Jr, Bufalino R, Zurrida S, Collini P, Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer. 1996; 77: 1303-1310.
19. The authors should at least quote S Ogino et al. Nat Rev Clin Oncol 2011.
20. Galon J et al. J Transl Med 2012; and discuss the importance of integrated analyses of tumor molecular changes and host immune factorsin the future studies.
21. Kunisaki C, Takahashi M, Ono HA, Oshima T, Takagawa R, Kimura J, et al. Inflammation-based prognostic score predicts survival in patients with advanced gastric cancer receiving biweekly docetaxel and s-1 combination chemotherapy. Oncology. 2012; 83(4): 183-91. Epub 2012 Aug 11.
22. Wang DS, Ren C, Qiu MZ, Luo HY, Wang ZQ, Zhang DS, et al. Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer. Tumour Biol. 2012 Jun; 33(3): 749-56. Epub 2011 Dec 24.
23. Bingle L, Brown NJ, Lewis CE. The role of tumourassociatedö macrophages in tumour progression: implications for new anticancer therapies. J Pathol. 2002; 196: 254-265.
24. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011; 11: 723-737.
25. Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011; 11: 762-774.
26. Leitch EF, Chakrabarti M, Crozier JE, McKee RF, Anderson JH, Horgan PG, et al. Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer. Br J Cancer. 2007; 97: 1266-1270.
27. Kim BW, Jeon YE, Cho H, Nam EJ, Kim SW, Kim S, et al. Pre-treatment diagnosis of endometrial cancer through a combination of CA125 and multiplication of neutrophil and monocyte.J Obstet Gynaecol Res. 2012 Jan; 38(1): 48-56. doi: 10.1111/j.1447-0756.2011.01694.x. Epub 2011 Dec 6.
28. Lee YY, Choi CH, Sung CO, Do IG, Huh S, Song T, et al. Prognostic value of pre-treatment circulating monocyte count in patients with cervical cancer: comparison with SCC-Ag level. Gynecol Oncol. 2012 Jan; 124(1): 92-7. Epub 2011 Oct 19.
29. Sasaki A, Iwashita Y, Shibata K, Matsumoto T, Ohta M, Kitano S. Prognostic value of preoperative peripheral blood monocyte count in patients with hepatocellular carcinoma. Surgery. 2006 Jun; 139(6): 755-64.
30. Leitch EF, Chakrabarti M, Crozier JE, McKee RF, Anderson JH, Horgan PG, et al. Comparison of the prognostic value of selected markers of the systemic inflammatory response in patients with colorectal cancer. Br J Cancer. 2007 Nov 5; 97(9): 1266-70. Epub 2007 Oct 9.
31. Ries LAG, Young JL, Keel GE, Eisner MP, Lin YD, Horner M-J (editors). SEER Survival Monograph: Cancer Survival Among Adults: U.S. SEER Program, 1988-2001, Patient and Tumor Characteristics. National Cancer Institute, SEER Program, NIH Pub. No. 07-6215, Bethesda, MD, 2007.
32. Mihmanli M, Dilege E, Demir U, et al. The use of tumor markers as predictors of prognosis in gastric cancer. Hepatogastroenterology. 2004; 51: 1544.
33. Kochi M, Fujii M, Kanamori N, et al. Evaluation of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. Gastric Cancer. 2000; 3: 177.
34. Bold RJ, Ota DM, Ajani JA, Mansfield PF. Peritoneal and serum tumor markers predict recurrence and survival of patients with resectable gastric cancer. Gastric Cancer. 1999; 2: 1.
35. Peng LS, Zhuang Y, Shi Y, Zhao YL, Wang TT, Chen N et al. Increased tumor-infiltrating CD8(+)Foxp3 (+) T lymphocytes are associated with tumor progression in human gastric cancer. Cancer Immunol Immunother. 2012 May 22.
36. Kim HI, Kim H, Cho HW, Kim SY, Song KJ, HyungWJ et al. The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer. J Surg Oncol. 2011 Dec; 104(7): 728-33.
37. Wang B, Xu D, Yu X, Ding T, Rao H, Zhan Y, et al. Association of intra-tumoral infiltrating macrophages and regulatory T cells is an independent prognostic factor in gastric cancer after radical resection. Ann Surg Oncol. 2011 Sep; 18(9): 2585-93.
38. Lee HE, Chae SW, Lee YJ, Kim MA, Lee HS, Lee BL, et al. Prognostic implications of type and density of tumourinfiltrating lymphocytes in gastric cancer. Br J Cancer. 2008 Nov 18; 99(10): 1704-11. Epub 2008 Oct 21.
39. Shen Z, Zhou S, Wang Y, Li RL, Zhong C, Liang C, et al. Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer. J Cancer Res Clin Oncol. 2010 Oct; 136(10): 1585-95.
40. Haas M, Dimmler A, Hohenberger W, Grabenbauer GG, Niedobitek G, et al. Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia. BMC Gastroenterol. 2009 Sep 4; 9: 65.
41. Kono K, Ichihara F, Iizuka H, Sekikawa T, Matsumoto Y. Differences in the recognition of tumor-specific CD8+ T cells derived from solid tumor, metastatic lymph nodes and ascites in patients with gastric cancer. Int J Cancer. 1997 Jun 11; 71(6): 978-81.
42. American Joint Committee on Cancer Staging Manual, 7th, Edge SB, Byrd DR, Compton CC, et al (eds), Springer, New York 2010, p. 117.