Diagnostic performance of a tear protein panel in early dry eye

Molecular Vision

Volumn 19, Issue , 2013, Pages 1247-1257

  Versura, Piera ^a   Bavelloni, Alberto ^b   Grillini, Marco ^a   Fresina, Michela ^a   Campos, Emilio C ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LACTOFERRIN; LIPOCALIN 1; LYSOZYME; LYSOZYME C; SERUM ALBUMIN; TEAR PROTEIN; TRANSFERRIN; UNCLASSIFIED DRUG; ZINC ALPHA2 GLYCOPROTEIN;

ADULT; AMINO ACID SEQUENCE; ANALYZER; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; DRY EYE; EARLY DIAGNOSIS; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MAXIMUM LIKELIHOOD METHOD; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; OCULAR SURFACE DISEASE INDEX SCORE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEIVER OPERATING CHARACTERISTIC; SCHIRMER TEST; SENSITIVITY AND SPECIFICITY; STAINING; TEAR FILM;

ADULT; CASE-CONTROL STUDIES; DATABASES, PROTEIN; DEMOGRAPHY; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DRY EYE SYNDROMES; EYE PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 84878920082     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Bron AJ, Yokoi N, Gafney E, Tiffany JM. Predicted phenotypes of dry eye: proposed consequences of its natural history. Ocul Surf 2009; 7:78-92.[PMID: 19383277].
2. Nichols KK, Nichols JJ, Mitchell GL. The lack of association between signs and symptoms in patients with dry eye disease. Cornea 2004; 23:762-70.[PMID: 15502475].
3. Zhou L, Beuerman RW. Tear analysis in ocular surface diseases. Prog Retin Eye Res 2012; 31:527-50.[PMID: 22732126].
4. Tomosugi N, Kitagawa K, Takahashi N, Sugai S, Ishikawa I. Diagnostic potential of tear proteomic patterns in Sjogren's syndrome. J Proteome Res 2005; 4:820-5.[PMID: 15952728].
5. Giusti L, Baldini C, Bazzichi L, Bombardieri S, Lucacchini A. Proteomic diagnosis of Sjögren's syndrome. Expert Rev Proteomics 2007; 4:757-67.[PMID: 18067414].
6. Versura P, Frigato M, Cellini M, Mulè R, Malavolta N, Campos EC. Diagnostic performance of tear function tests in Sjogren's syndrome patients. Eye (Lond) 2007; 21:229-37.[PMID: 16397619].
7. Nguyen CQ, Peck AB. Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease. Ocul Surf 2009; 7:11-27.[PMID: 19214349].
8. Boehm N, Riechardt AI, Wiegand M, Pfeiffer N, Grus FH. Pro-inflammatory cytokine profiling of tears from dry-eye patients by means of antibody microarrays. Invest Ophthalmol Vis Sci 2011; 52:7725-30.[PMID: 21775656].
9. Huang JF, Zhang Y, Rittenhouse KD, Pickering EH, McDowell MT. Evaluations of tear protein markers in dry eye disease: repeatability of measurement and correlation with disease. Invest Ophthalmol Vis Sci 2012; 53:4556-64.[PMID: 22695964].
10. Sambursky R, Davitt WF, Latkany R, Tauber S, Starr C, Friedberg M, Dirks MS, McDonald M. Sensitivity and specificity of a Point-of-care Matrix Metalloproteinase 9 immunoassay for diagnosing inflammation related to Dry Eye. JAMA Ophthalmol 2013; 131:24-8.[PMID: 23307206].
11. Srinivasan S, Thangavelu M, Zhang L, Green KB, Nichols KK. iTRAQ quantitative proteomics in the analysis of tears in dry eye patients. Invest Ophthalmol Vis Sci 2012; 53:5052-9.[PMID: 22736608].
12. Mann AM, Tighe BJ. Tear analysis and lens-tear interactions Part I. Protein fingerprinting with microfluidic technology. Cont Lens Anterior Eye 2007; 30:163-73.[PMID: 17499010].
13. Versura P, Bavelloni A, Blalock W, Fresina M, Campos EC. A rapid standardized quantitative microfluidic system approach for evaluating human tear proteins. Mol Vis 2012; 18:2526-37.[PMID: 23112568].
14. Asbell PA, Lemp MA. Dry Eye Disease: The Clinician's guide to diagnosis and treatment. New York: Thieme; 2007.
15. Schiffman RM, Christanson MD, Jacobsen G. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol 2000; 118:615-21.[PMID: 10815152].
16. No authors listed. Methodologies to diagnose and monitor Dry Eye disease. In: 2007 Report of the International Dry Eye WorkShop (DEWS). Ocul Surf 2007; 5:108-52.[PMID: 17508118].
17. Lemp MA. Report of the National Eye Institute/Industry work¬shop on clinical trials in Dry Eyes. CLAO J 1995; 21:221-32.[PMID: 8565190].
18. Bioinformatics FMH. applications in life and environmental sciences. Springer 2009, pp. 110.
19. Friedman NJ. Impact of dry eye disease and treatment on quality of life. Curr Opin Ophthalmol 2010; 21:310-6.[PMID: 20467319].
20. Enríquez-de-Salamanca A, Bonini S, Calonge M. Molecular and cellular biomarkers in dry eye disease and ocular allergy. Curr Opin Allergy Clin Immunol 2012; 12:523-33.[PMID: 22895048].
21. Na KS, Mok JW, Kim JY, Rho CR, Joo CK. Correlations between tear cytokines, chemokines, and soluble receptors and clinical severity of dry eye disease. Invest Ophthalmol Vis Sci 2012; 53:5443-50.[PMID: 22789923].
22. Aluru SV, Agarwal S, Srinivasan B, Iyer GK, Rajappa SM, Tatu U, Padmanabhan P, Subramanian N, Narayanasamy A. Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome. PLoS ONE 2012; 7:e51979
23. McKown RL, Wang N, Raab RW, Karnati R, Zhang Y. Lacritin and other new proteins of the lacrimal functional unit. Exp Eye Res 2009; 88:848-58.[PMID: 18840430].
24. Sullivan BD, Crews LA, Sönmez B, de la Paz MF, Comert E, Charoenrook V, de Araujo AL, Pepose JS, Berg MS, Kosheleff VP, Lemp MA. Clinical utility of objective tests for dry eye disease: variability over time and implications for clinical trials and disease management. Cornea 2012; 31:1000-8.[PMID: 22475641].
25. Versura P, Profazio V, Campos EC. Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases. Curr Eye Res 2010; 35:553-64.[PMID: 20597641].
26. Berta A. A polyacrylamide-gel electrophoretic study of human tear proteins. Graefes Arch Clin Exp Ophthalmol 1982; 219:95-9.[PMID: 7141235].
27. Caffery B, Joyce E, Boone A, Slomovic A, Simpson T, Jones L, Senchyna M. Tear lipocalin and lysozyme in Sjögren and non-Sjögren dry eye. Optom Vis Sci 2008; 85:661-7.[PMID: 18677232].
28. Ohashi Y, Dogru M, Tsubota K. Laboratory findings in tear fluid analysis. Clin Chim Acta 2006; 369:17-28.[PMID: 16516878].
29. Lema I, Brea D, Rodriguez-Gonzalez R, Diez-Feijoo E, Sobrino T. Proteomic analysis of the tear film in patients with keratoconus. Mol Vis 2010; 16:2055-61.[PMID: 21042560].
30. Dartt DA. Tear lipocalin: structure and function. Ocul Surf 2011; 9:126-38.[PMID: 21791187].
31. Yamada M, Mochizuki H, Kawai M, Tsubota K, Bryce TJ. Decreased tear lipocalin concentration in patients with meibomian gland dysfunction. Br J Ophthalmol 2005; 89:803-5.[PMID: 15965153].
32. Versura P, Nanni P, Bavelloni A, Blalock WL, Piazzi M, Roda A, Campos EC. Tear proteomics in evaporative dry eye disease. Eye (Lond) 2010; 24:1396-402.[PMID: 20150925].
33. Hassan M, Waheed A, Yadav S, Singh TP, Ahmad F. Zinc A2-Glycoprotein: a multidisciplinary protein. Mol Cancer Res 2008; 6:892-906.[PMID: 18567794].
34. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ. Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha-(2)-glycoprotein. Biochim Biophys Acta 2004; 1636:59-68.[PMID: 14984739].
35. Molloy MP, Bolis S, Herbert BR, Ou K, Tyler MI, van Dyk DD, Willcox MD. Gooley AA, Williams KL, Morris CA, Walsh BJ. Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value. Electrophoresis 1997; 18:2811-5.[PMID: 9504814].
36. Ratledge C, Dover LG. Iron metabolism in pathogenic bacteria. Annu Rev Microbiol 2000; 54:881-941.[PMID: 11018148].
37. Versura P, Profazio V, Fresina M, Campos EC. A novel scraping cytology score system (SCSS) grades inflammation in Dry Eye patients. Curr Eye Res 2009; 34:340-6.[PMID: 19401876].
38. Nichols JJ, Green-Church KB. Mass Spectrometry-based proteomic analyses in Contact lens-related Dry Eye. Cornea 2009; 28:1109-17.[PMID: 19770725].
39. No authors listed. The definition and classification of Dry Eye disease. In: 2007 Report of the International Dry Eye WorkShop (DEWS). Ocul Surf 2007; 5:75-92.[PMID: 17508116].
40. García-Castiñeiras S. Iron, the retina and the lens: a focused review. Exp Eye Res 2010; 90:664-78.[PMID: 20230820].
41. Nguyen DH, Beuerman R, Halbert C, Qiangwei MA, Sun G. Characterization of immortalized rabbit lacrimal gland epithelial cells. In Vitro Cell Dev Biol Anim 1999; 35:198-204.[PMID: 10478799].
42. Edman MC, Marchelletta RR, Hamm-Alvarez SS. Lachrymal gland overview. In: Ocular periphery and disorders. Dartt DA et al (editors), 2011, Academic Press, Oxford, UK Publisher. pp 68-74.
43. Görögh T, Rudolph P, Meyer JE, Werner JA, Lippert BM, Maune S. Separation of beta2-transferrin by denaturing gel electrophoresis to detect cerebrospinal fluid in ear and nasal fluids. Clin Chem 2005; 51:1704-10.[PMID: 16020492].
44. Vanarsa K, Ye Y, Han J, Xie C, Mohan C, Wu T. Inflammation associated anemia and ferritin as disease markers in SLE. Arthritis Res Ther 2012; 14:R182-Epub ahead of print[PMID: 22871034].
45. Fullard RJ, Tucker DL. Changes in human tear protein levels with progressively increasing stimulus. Invest Ophthalmol Vis Sci 1991; 32:2290-301.[PMID: 2071341].