Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment

Experimental Parasitology

Volumn 134, Issue 4, 2013, Pages 443-446

  Guerra Giraldez, Cristina ^a   Marzal, Miguel ^a   Cangalaya, Carla ^a   Balboa, Diana ^a   Orrego, Miguel Ángel ^a   Paredes, Adriana ^a   Gonzales Gustavson, Eloy ^b   Arroyo, Gianfranco ^b   García, Hector H ^a,c   González, Armando E ^b   Mahanty, Siddhartha ^a,d   Nash, Theodore E ^a,d  

^a UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^b UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS   (Peru)

^c INSTITUTO NACIONAL DE CIENCIAS NEUROLÓGICAS   (Peru)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Blood brain barrier; Neurocysticercosis; Praziquantel; Taenia solium

Indexed keywords

ANTHELMINTIC AGENT; EVANS BLUE; PRAZIQUANTEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CYST; CONTROLLED STUDY; NEUROCYSTICERCOSIS; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; SINGLE DRUG DOSE; SWINE; TAENIA SOLIUM; TAENIASIS; TROPICS;

BLOOD-BRAIN BARRIER; NEUROCYSTICERCOSIS; PRAZIQUANTEL; TAENIA SOLIUM;

ANIMALS; ANTHELMINTICS; BLOOD-BRAIN BARRIER; BRAIN; COLORING AGENTS; EVANS BLUE; EXTRAVASATION OF DIAGNOSTIC AND THERAPEUTIC MATERIALS; NEUROCYSTICERCOSIS; PRAZIQUANTEL; SWINE; SWINE DISEASES; TAENIA SOLIUM;

SUIDAE; TAENIA SOLIUM;

EID: 84878915948     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2013.05.005     Document Type: Article

References (34)

1. Abbott N.J., Patabendige A.A., Dolman D.E., Yusof S.R., Begley D.J. Structure and function of the blood-brain barrier. Neurobiol. Dis. 2010, 37(1):13-25.
2. Allen T.H., Orahovats P.D. Combination of toluidine dye isomers with plasma albumin. Am. J. Physiol. 1950, 161(3):473-482.
3. Alvarez J.I., Teale J.M. Breakdown of the blood-brain barrier and blood-cerebrospinal fluid barrier is associated with differential leukocyte migration in distinct compartments of the CNS during the course of murine NCC. J. Neuroimmunol. 2006, 173:45-55.
4. Araya R., Kudo M., Kawano M., Ishii K., Hashikawa T., Iwasato T., Itohara S., Terasaki T., Oohira A., Mishina Y., Yamada M. BMP signalling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain barrier. Mol. Cell. Neurosci. 2008, 38(3):417-430.
5. Clasen R., Pandolfi S., Hass G. Vital staining, serum albumin and the blood-brain barrier. J. Neuropath. Exp. Neurol. 1970, 29(2):266-284.
6. Egima C.M., Macedo S.F., Sasso G.R., Covarrubias C., Cortez M., Maeda F.Y., Costa F.T., Yoshida N. Co-infection with Trypanosoma cruzi protects mice against early death by neurological or pulmonary disorders induced by Plasmodium berghei ANKA. Malar. J. 2007, 6:90.
7. Evans H.M., Schulemann W. The action of vital stains belonging to the benzidine group. Science 1914, 39(1004):443-454.
8. Garcia H.H., Gonzalez A.E., Gilman R.H. Diagnosis, treatment and control of Taenia solium cysticercosis. Curr. Opin. Infect. Dis. 2003, 16(5):411-419.
9. Garcia H.H., Del Brutto O.H., CWGP Neurocysticercosis: updated concepts about an old disease. Lancet Neurol. 2005, 4(10):653-661.
10. Gonzalez A.E., Bustos J.A., Jimenez J.A., Rodriguez M.L., Ramirez M.G., Gilman R.H., Garcia H.H. Efficacy of diverse antiparasitic treatments for cysticercosis in the pig model. Am. J. Trop. Med. Hyg. 2012, 87(2):292-296. Cysticercosis working group in Peru.
11. Hawkins B.T., Egleton R.D. Pathophysiology of the blood-brain barrier: animal models and methods. Curr. Top. Dev. Biol. 2008, 80:277-309.
12. Janzer R.C., Raff M.C. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 1987, 325:253-257.
13. Jena A., Sanchetee P.C., Tripathi R., Jain R.K., Gupta A.K., Sapra M.L. MR observations on the effects of praziquantel in neurocysticercosis. Magn. Reson. Imaging 1992, 10(1):77-80.
14. Kaya M., Anishali B. Assessment of permeability in barrier type of endothelium in brain using tracers: Evans blue, sodium fluorescein, and horseradish peroxidase. Methods Mol. Biol. 2011, 763:369-382.
15. Lin Y., Pan Y., Wang M., Huang X., Yin Y., Wang Y., Jia F., Xiong W., Zhang N., Jiang J.Y. Blood-brain barrier permeability is positively correlated with cerebral microvascular perfusion in the early fluid percussion-injured brain of the rat. Lab. Invest. 2012, 92(11):1623-1634.
16. Manaenko A., Chen H., Kammer J., Zhang J.H., Tang J. Comparison of Evans Blue injection routes: intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J. Neurosci. Methods 2011, 195(2):206-210.
17. Marchi N., Teng Q., Nguyen M.T., Franic T., Desai N.K., Masaryk T., Rasmussen P., Trasccuattum S., Janigro D. Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood- brain barrier integrity. BMC Neurosci. 2010, 11:34-44.
18. McCarty J.H. Cell biology of the neurovascular unit: implications for drug delivery across the blood-brain barrier. Assay Drug Dev. Technol. 2005, 3(1):89-95.
19. Menkin V., Menkin M.F. Studies on inflammation: II. A measure of the permeability of capillaries in an inflamed area. J. Exp. Med. 1930, 51(2):285-293.
20. Moody D.M. The blood-brain barrier and blood-cerebral spinal fluid barrier. Semin. Cardiothorac. Vasc. Anesth. 2006, 10(2):128-131.
21. Nash T.E., Garcia H.H. Diagnosis and treatment of neurocysticercosis. Nat. Rev. Neurol. 2011, 7(10):584-594.
22. Nash T.E., Singh G., White A.C., Rajshekhar V., Loeb J.A., Proaño J.V., Takayanagui O.M., Gonzalez A.E., Butman J.A., DeGiorgio C., Del Brutto O.H., Delgado-Escueta A., Evans C.A.W., Gilman R.H., Martinez S.M., Medina M.T., Pretell E.J., Teale J., Garcia H.H. Treatment of neurocysticercosis: current status and futureresearchneeds. Neurology 2006, 67(7):1120-1127.
23. Nico B., Ribatti D. Morphofunctional aspects of the blood-brain barrier. Curr. Drug Metab. 2012, 13(1):50-60.
24. Okamura T., Ishibashi N., Kumar T.S., Zurakowski D., Iwata Y., Lidov H.G.W., Jonas R.A. Hypothermic circulatory arrest increases permeability of the blood brain barrier in watershed areas. Ann. Thorac. Surg. 2010, 90(6):2001-2008.
25. Patterson C.E., Rhoades R.A., García J.G.N. Evans blue dye as a marker of albumin clearance in cultured endothelial monolayer and isolated lung. J. Appl. Physiol. 1992, 72(3):865-873.
26. Rickard M.D., Williams J.F. Hydatidosis/cysticercosis: immunemechanisms and immunizationagainstinfection. Adv. Parasitol. 1982, 21:229-296.
27. Rubin L.L., Staddon J.M. The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 1999, 22:11-28.
28. Sikasunge C.S., Johansen M.V., Willingham A.L., Leifsson P.S., Phiri I.K. Taenia soliumporcine cysticercosis: viability of cysticerci and persistency of antibodies and cysticercal antigens after treatment with oxfendazole. Vet. Parasitol. 2008, 158(1-2):57-66.
29. Sikasunge C.S., Johansen M.V., Phiri I.K., Willingham A.L., Leifsson P.S. The immune response in Taenia solium neurocysticercosis in pigs is associated with astrogliosis, axonal degeneration and altered blood-brain barrier permeability. Vet. Parasitol. 2009, 160(3-4):242-250.
30. Teitelbaum G.P., Otto R.J., Lin M., Watanabe A.T., Stull M.A., Manz H.J., Bradley W.G. MR imaging of neurocysticercosis. AJR. Am. J. Roentgenol. 1989, 153(4):857-866.
31. Vaz R., Sarmento A., Borges N., Cruz C., Azevedo T. Experimental traumatic cerebral contusion: morphological study of brain microvessels and characterization of the oedema. Acta Neurochir. (Wien) 1998, 140:76-81.
32. Wei K.-C., Chu P.-C., Wang H.-Y., Huang C.-Y., Chen P.-Y., Tsai H.-C., Lu Y.-J., Lee P.-Y., Tseng I.-C., Feng L.-Y., Hsu P.-W., Yen T.-C., Liu H.-L. Focused ultrasound-induced blood-brain barrier opening to enhance tmozolomide delivery for glioblastoma treatment: a preclinical study. PloS One 2013, 8(3):e58995.
33. Wolburg H., Noell S., Mack A., Wolburg-Buchholz K., Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell. Tissue Res. 2009, 335(1):75-96.
34. Zhang G.S., Tian Y., Huang J.Y., Tao R.R., Liao M.H., Lu Y.M., Ye W.F., Wang R., Fukunaga K., Lou Y.J., Han F. The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia. CNS Neurosci. Ther. 2013, 19(1):53-60.