Evaluation of poly (1, 6-bis-(p-carboxyphenoxy) hexane-co-sebacic acid microspheres for controlled basal insulin delivery

Pharmaceutical Research

Volumn 30, Issue 3, 2013, Pages 627-640

  Manoharan, Chandrasekar ^a,b   Singh, Jagdish ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

biocompatibility; controlled drug release; microspheres; polyanhydride; protein

Indexed keywords

COPOLYMER; MICROSPHERE; POLY 1,6 BIS(PARA CARBOXYPHENOXY)HEXANE CO SEBACIC ACID MICROSPHERE; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; ZINC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; DRUG TOXICITY; EMBRYO; EMULSION; ENCAPSULATION; EVAPORATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MICROSCOPY; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL LINE; CELL SURVIVAL; DECANOIC ACIDS; DELAYED-ACTION PREPARATIONS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICROSPHERES; POLYESTERS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SKIN;

EID: 84878889811     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0880-8     Document Type: Article

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