Characteristics of Patients With the “Malignant Obesity Hypoventilation Syndrome” Admitted to an ICU

Journal of Intensive Care Medicine

Volumn 28, Issue 2, 2013, Pages 124-130

  Marik, Paul E ^a   Desai, Himanshu ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

diabetes; diastolic heart failure; metabolic syndrome; myocardial hypotrophy; nonacholic steatohepatitis; obesity; obesity hypoventilation syndrome; Pickwickian; pulmonary hypertension; vitamin D deficiency

Indexed keywords

AGED; ARTICLE; BODY MASS; DIFFERENTIAL DIAGNOSIS; FEMALE; HEART LEFT VENTRICLE FUNCTION; HOSPITAL ADMISSION; HUMAN; HYPERCAPNIA; INTENSIVE CARE UNIT; METABOLIC SYNDROME X; MIDDLE AGED; MULTIPLE ORGAN FAILURE; OBESITY HYPOVENTILATION SYNDROME; STATISTICS;

AGED; BODY MASS INDEX; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; HYPERCAPNIA; INTENSIVE CARE UNITS; METABOLIC SYNDROME X; MIDDLE AGED; MULTIPLE ORGAN FAILURE; OBESITY HYPOVENTILATION SYNDROME; PATIENT ADMISSION; VENTRICULAR DYSFUNCTION, LEFT;

MLCS; MLOWN;

EID: 84878889532     PISSN: 08850666     EISSN: 15251489     Source Type: Journal    
DOI: 10.1177/0885066612444261     Document Type: Article

References (64)

1. Finucane MM Stevens GA Cowan MJ. National, regional, and global trends in body-mass index since 1980: systemtic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377(9765):557–567.
2. Flegal KM Carroll MD Ogden CL Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010;303(3):235–241.
3. Calle EE Thun MJ Petrelli JM Rodriguez C Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341(15):1097–1105.
4. de Gonzalez AB Hartge P Cerhan JR. Body-Mass index and mortality among 1.46 million white adults. N Engl J Med. 2010;363(23):2211–2219.
5. Flegal KM Graubard BI Williamson DF. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA. 2007;298(17):2028–2037.
6. Piper AJ Grunstein RR. Obesity hypoventilation syndrome. Mechanisms and management. Am J Respir Crit Care Med. 2011;183(3):292–298.
7. Mokhlesi B Tulaimat A Faibussowitsch I Wang Y Evans AT. Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea. Sleep Breath. 2007;11(2):117–124.
8. Kaw R Hernandez AV Walker E Aboussouan L Mokhlesi B. Determinants of hypercapnia in obese patients with obstructive sleep apnea: a systematic review and metaanalysis of cohort studies. Chest. 2009;136(3):787–796.
9. Nowbar S Burkart KM Gonzales R. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med. 2004;116(1):1–7.
10. Trakada GP Steiropoulos P Nena E Constandinidis TC Bouros D. Prevalence and clinical characteristics of obesity hypoventilation syndrome among individuals reporting sleep-related breathing symptoms in northern Greece. Sleep Breath. 2010;14(4):381–386.
11. Resta O Foschino Barbaro MP Brindicci C Nocerino MC Caratozzolo G Carbonara M. Hypercapnia in overlap syndrome: possible determinant factors. Sleep Breath. 2002;6(1):11–18.
12. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Insitute of Medicine. Dietary Reference Intakes for Calicum, and VItamin D. http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx. Washington, DC: National Academy Press; 2010.
13. Talmor D Sarge T Malhotra A. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med. 2008;359(20):2095–2104.
14. Cuspidi C Giudici V Negri F. Improving cardiovascular risk stratification in essential hypertensive patients by indexing left ventricular mass to height(2.7). J Hypertens. 2009;27(12):2465–2471.
15. Quinones MA Otto CM Stoddard M. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr. 2002;15(2):167–184.
16. Grundy SM Cleeman JI Daniels SR. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735–2752.
17. Freedman DS Khan LK Serdula MK Galuska DA Dietz WH. Trends and correlates of class 3 obesity in the United States from 1990 through 2000. JAMA. 2002;288(14):1758–1761.
18. Kessler R Chaouat A Schinkewitch P. The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases. Chest. 2001;120(2):369–376.
19. Berg G Delaive K Manfreda J Walld R Kryger MH. The use of health-care resources in obesity-hypoventilation syndrome. Chest. 2001;120(2):377–383.
20. Sharp JT Henry JP Sweany SK Meadows WR Pietras RJ. The total work of breathing in normal and obese men. J Clin Invest. 1964;43:728–739.
21. Hirani A Cavallazzi R Shnister A Paul EM. Airway pressure release ventilation (APRV) for theatment of severe life-threatening ARDS in a morbidly obese patient. Crit Care Shock. 2008;11(4):132–136.
22. Vgontzas AN. Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance? Arch Physiol Biochem. 2008;114(4):211–223.
23. Zamarron C Garcia Paz V Riveiro A. Obstructive sleep apnea syndrome is a systemic disease. Current evidence. Eur J Intern Med. 2008;19(6):390–398.
24. Nguyen NT Magno CP Lane KT Hinojosa MW Lane JSI. Association of hypertension, diabetes, dyslipidemia, and metabolic syndrome with obesity: findings from the National Health and Nutrition Examination Survey, 1999 to 2004. J Am Coll Surg. 2008;207(6):928–934.
25. Masaidi M Cuspidi C Negri F. Left and right ventricular structural changes in obese hypertensives. Blood Press. 2009;18(1-2):23–29.
26. Rodrigues SL Baldo MP Sa CR. Anthropometric measures of increased central and overall adiposity in association with echocardiographic left ventricular hypertrophy. Hypertens Res. 2010;33(1):83–87.
27. Libhaber CD Norton GR Majane OH. Contribution of central and general adiposity to abnormal left ventricular diastolic function in a community sample with a high prevalence of obesity. Am J Cardiol. 2009;104(11):1527–1533.
28. Jhaveri RR Pond KK Hauser TH. Cardiac remodeling after substantial weight loss: a prospective cardiac magnetic resonance study after bariatric surgery. Surg Obes Relat Dis. 2009;5(6):648–652.
29. Ebinc H Ebinc FA Ozkurt ZN. Impact of adiponectin on left ventricular mass index in non-complicated obese subjects. Endocr J. 2008;55(3):523–528.
30. Malavazos AE Ermetici F Morricone L. Association of increased plasma cardiotrophin-1 with left ventricular mass indexes in normotensive morbid obesity. Hypertension. 2008;51(2):e8–e9.
31. Owan T Litwin SE. Is there a cardiomyopathy of obesity? Curr Heart Fail Rep. 2007;4(4):221–228.
32. Sugerman HJ Baron PL Fairman RP Evans CR Vetrovec GW. Hemodynamic dysfunction in obesity hypoventilation syndrome and the effects of treatment with surgically induced weight loss. Ann Surg. 1988;207(5):604–613.
33. Leung CC Moondra V Catherwood E Andrus BW. Prevalence and risk factors of pulmonary hypertension in patients with elevated pulmonary venous pressure and preserved ejection fraction. Am J Cardiol. 2010;106(2):284–286.
34. Yoneda M Nozaki Y Endo H. Serum ferritin is a clinical biomarker in Japanese patients with nonalcoholic steatohepatitis (NASH) independent of HFE gene mutation. Dig Dis Sci. 2010;55(3):808–814.
35. Zelber-Sagi S Nitzan-Kaluski D Halpern Z Oren R. NAFLD and hyperinsulinemia are major determinants of serum ferritin levels. J Hepatol. 2007;46(4):700–707.
36. Akashiba T Akahoshi T Kawahara S. Clinical characteristics of obesity-hypoventilation syndrome in Japan: a multi-center study. Intern Med. 2006;45(20):1121–1125.
37. Pagano G Pacini G Musso G. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology. 2002;35(2):367–372.
38. Kashyap SR Diab DL Baker AR. Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort. Obesity. 2009;17(9):1696–1701.
39. Assy N Kaita K Mymin D Levy C Rosser B Minuk G. Fatty infiltration of liver in hyperlipidemic patients. Dig Dis Sci. 2000;45(10):1929–1934.
40. Ulitsky A Ananthakrishnan AN Komorowski R. A noninvasive clinical scoring model predicts risk of nonalcoholic steatohepatitis in morbidly obese patients. Obes Surg. 2010;20(6):685–691.
41. Hunley TE Ma LJ Kon V. Scope and mechanisms of obesity-related renal disease. Curr Opin Nephrol Hypertens. 2010;19(3):227–234.
42. Othman M Kawar B El Nahas AM. Influence of obesity on progression of non-diabetic chronic kidney disease: a retrospective cohort study. Nephron Clin Pract. 2009;113(1):c16–c23.
43. Weisinger JR Kempson RL Eldridge FL Swenson RS. The nephrotic syndrome: a complication of massive obesity. Ann Intern Med. 1974;81(4):440–447.
44. Serra A Romero R Lopez D. Renal injury in the extremely obese patients with normal renal function. Kidney Int. 2008;73(8):947–955.
45. Navaneethan SD Yehnert H. Bariatric surgery and progression of chronic kidney disease. Surg Obes Relat Dis. 2009;5(6):662–665.
46. Jorde R Sneve M Emaus N Figenschau Y Grimnes G. Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromso study. Eur J Nutr. 2010;49(7):401–407.
47. Cheng S Massaro JM Fox CS. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes. 2010;59(1):242–248.
48. Fish E Beverstein G Olson D Reinhardt S Garren M Gould J. Vitamin D status of morbidly obese bariatric surgery patients. J Surg Res. 2010;164(2):198–202.
49. Baz-Hecht M Goldfine AB. The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes. 2010;17(2):113–119.
50. Osei K. 25-OH vitamin D: is it the universal panacea for metabolic syndrome and type 2 diabetes? J Clin Endocrinol Metab. 2010;95(9):4220–4222.
51. Nikooyeh B Neyestani TR Farvid M. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr. 2011;93(4):764–771.
52. Tzotzas T Papadopoulou FG Tziomalos K. Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab. 2010;95(9):4251–4257.
53. Gilbert-Diamond D Baylin A Mora-Plazas M. Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. Am J Clin Nutr. 2010;92(6):1446–1451.
54. Lagunova Z Porojnicu AC Grant WB Bruland Ø Moan JE. Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association? Mol Nutr Food Res. 2010;54(8):1127–1133.
55. Priou P Hamel JF Person C. Long-term outcome of noninvasive positive pressure ventilation for obesity hypoventilation syndrome. Chest. 2010;138(1):84–90.
56. Perez de Llano LA Golpe R Ortiz PM. Short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome. Chest. 2005;128(2):587–594.
57. Masa JF Celli BR Riesco JA Hernández M Sánchez De Cos J Disdier C. The obesity hypoventilation syndrome can be treated with noninvasive mechanical ventilation. Chest. 2001;119(4):1102–1107.
58. Sjostrom L Narbro K Sjostrom CD. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–752.
59. Rubino F Kaplan LM Schauer PR Cummings DE; Diabetes Surgery Summit Delegates. The Diabetes Surgery Summit consensus conference: recommendations for the evaluation and use of gastrointestinal surgery to treat type 2 diabetes mellitus. Ann Surg. 2010;251(3):399–405.
60. Greenburg DL Lettieri CJ Eliasson AH. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med. 2009;122(6):535–542.
61. Lumachi F Marzano B Fanti G Basso SM Mazza F Chiara GB. Hypoxemia and hypoventilation syndrome improvement after laparoscopic bariatric surgery in patients with morbid obesity. In Vivo. 2010;24(3):329–331.
62. Garza CA Pellikka PA Somers VK. Structural and functional changes in left and right ventricles after major weight loss following bariatric surgery for morbid obesity. Am J Cardiol. 2010;105(4):550–556.
63. Dixon JB Bhathal PS O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology. 2001;121(1):91–100.
64. Badesch DB Champion HC Sanchez MA. Diagnosis and assessment of pulmonary arterial hypertension. J Am Coll Cardiol. 2009;54(suppl 1):S55–S66.