The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: Is it mediated via adiponectin?

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 6, 2013, Pages 496-501

  Wright, Olivia R L ^a,b,c   Hickman, Ingrid J ^b,c,d   Petchey, William G ^a   Sullivan, Clair M ^d   Ong, Cynthia ^a,d   Rose, Felicity J ^b,c   Ng, Choaping ^b,c   Prins, Johannes B ^a,b,c   Whitehead, Jonathan P ^b,c   O'Moore Sullivan, Trisha M ^a,d,e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^c TRANSLATIONAL RESEARCH INSTITUTE   (Australia)

^d PRINCESS ALEXANDRA HOSPITAL   (Australia)

^e University of Queensland ^*  (Australia)

Author keywords

Adiponectin; Insulin sensitivity; Obesity; Vitamin d

Indexed keywords

25 HYDROXYVITAMIN D; ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; PARATHYROID HORMONE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY FAT; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADIPONECTIN; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MULTIVARIATE ANALYSIS; OBESITY; TRIGLYCERIDES; VITAMIN D;

EID: 84878868984     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0436     Document Type: Article

References (34)

1. Alemzaeh, R., and Kichler, J. 2012. Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. Metab. Syndr. Relat. Disord. 10(6): 422-429. doi:10.1089/met.2012.0056.PMID:22849753.
2. Andersen, R., Brot, C., Mejborn, H., Molgaard, C., Skovgaard, L.T., Trolle, E., et al. 2009. Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants. Eur. J. Clin. Nutr. 63(9): 1150-1153.doi:10.1038/ jcn.2009.18.PMID:19352377.
3. Bełtowski, J., Atanassova, P., Chaldakov, G.N., Jamroz-Wioeniewska, A., Kula, W., and Rusek, M. 2011. Opposite effects of pravastatin and atorvastatin on insulin sensitivity in the rat: Role of vitamin D metabolites. Atherosclerosis, 219(2): 526-531.doi:10.1016/j.atherosclerosis.2011.08.009.PMID:21889144.
4. Cheng, S., Massaro, J.M., Fox, C.S., Larson, M.G., Keyes, M.J., McCabe, E.L., et al. 2010. Adiposity, cardiometabolic risk, and vitamin D status: The Framingham Heart study. Diabetes, 59(1): 242-248.doi:10.2337/db09-1011.PMID: 19833894.
5. DeFronzo, R.A., and Tripathy, D. 2009. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care, 32(Suppl. 2): S157-S163. doi:10.2337/dc09-S302.PMID:19875544.
6. Dobnig, H., Pilz, S., Scharnagl, H., Renner, W., Seelhorst, U., Wellnitz, B., et al. 2008. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Arch. Intern. Med. 168(12): 1340-1349.doi:10.1001/archinte.168.12.1340.PMID: 18574092.
7. Flores, M. 2005. A role of vitamin D in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus? Nutr. Res. Rev. 18(02): 175-182. doi:10.1079/NRR2005104.PMID:19079903.
8. George, P.S., Pearson, E.R., and Witham, M.D. 2012. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 29(8): e142-e150.doi:10.1111/j.1464-5491.2012. 03672.x.PMID:22486204.
9. Grimnes, G., Figenschau, Y., Almås, B., and Jorde, R. 2011. Vitamin D, insulin secretion, sensitivity, and lipids. Diabetes, 60(11): 2748-2757.doi:10.2337/ db11-0650.PMID:21911741.
10. Gulseth, H.L., Gjelstad, I.M.F., Tierney, A.C., Lovegrove, J.A., Defoort, C., Blaak, E.E., et al. 2010. Serum vitamin D concentration does not predict insulin action or secretion in european subjects with the metabolic syndrome. Diabetes Care, 33(4): 923-925.doi:10.2337/dc09-1692.PMID:20067973.
11. Holick, M.F. 2007. Vitamin D deficiency. N. Engl. J. Med. 357: 266-281.
12. Hollis, B.W. 2008. Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs. Am. J. Clin. Nutr. 88(2): 507S-510S.PMID:18689391.
13. IDF. 2005. The IDF consensus worldwide definition of the metabolic syndrome. Available from http://www.idf.org.
14. Jain, R., von Hurst, P.R., Stonehouse, W., Love, D.R., Higgins, C.M., and Coad, J. 2012. Association of vitamin D receptor gene polymorphisms with insulin resistance and response to vitamin D. Metabolism, 61(3): 293-301.doi:10.1016/ j.metabol.2011.06.018.PMID:21871642.
15. Jorde, R., and Figenschau, Y. 2009. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hyroxyvitamin D levels. Eur. J. Nutr. 48: 349-354.doi:10.1007/s00394-009- 0020-3.PMID:19370371.
16. Jorde, R., and Grimnes, G. 2012. Vitamin D and Lipids. Circulation, 126(3): 252-254.doi:10.1161/circulationaha.112.119693.PMID:22718801.
17. Jorde, R., Sneve, M., Torjesen, P., and Figenschau, Y. 2010. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J. Intern. Med. 267(5): 462-472.doi:10.1111/j.1365-796.2009.02181.x.PMID:20141565.
18. Li, S., Shin, H.J., Ding, E.L., and van Dam, R.M. 2009. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. J. Am. Med. Assoc. 302(2): 179-188.doi:10.1001/jama.2009.976.PMID:19584347.
19. Lorente-Cebrian, S., Eriksson, A., and Dunlop, T. 2012. Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur. J. Nutr. 51: 335-342.doi:10.1007/s00394-011- 0218-z.PMID:21701898.
20. Lucio, M., Fekete, A., Weigert, C., Wägele, B., Zhao, X., Chen, J., et al. 2010. Insulin sensitivity is reflected by characteristic metabolic fingerprints - a fourier transform mass spectrometric non-targeted metabolomics approach. PLoS One, 5(10): e13317.doi:10.1371/journal.pone.0013317.PMID:20976215.
21. Maki, K.C., Rubin, M.R., Wong, L.G., McManus, J.F., Jensen, C.D., Marshall, J.W., et al. 2009. Serum 25-hydroxyvitamin D is independently associated with high-density lipoprotein cholesterol and the metabolic syndrome in men and women. J. Clin. Lipidol. 3: 289-296.doi:10.1016/j.jacl.2009.07.003.PMID: 21291826.
22. Mason, R.S., Sequeira, V.B., and Gordon-Thomson, C. 2011. Vitamin D: the light side of sunshine. Eur. J. Clin. Nutr. 65(9): 986-993.doi:10.1038/ejcn.2011.105. PMID:21731037.
23. Matsuda, M., and DeFronzo, R.A. 1999. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care, 22(9): 1462-1470.doi:10.2337/diacare.22.9.1462.PMID: 10480510.
24. Mazloomi, S., Sharifi, F., Hajihosseini, R., Kalantari, S., and Mazloomzadeh, S. 2012. Association between hypoadiponectinemia and low serum concentrations of calcium and vitamin D in women with polycystic ovary syndrome. ISRN Endocrinol.doi:10.5402/2012/949427.PMID:22363895.
25. O'Sullivan, A., Gibney, M.J., Connor, A.O., Mion, B., Kaluskar, S., Cashman, K.D., et al. 2011. Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol. Nutr. Food Res. 55(5): 679-690.doi:10.1002/mnfr.201000458. PMID:21240901.
26. Pajvani, U.B., Hawkins, M., Combs, T.P., Rajala, M.W., Doebber, T., Berger, J.P., et al. 2004. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J. Biol. Chem. 279(13): 12152-12162.doi:10.1074/jbc.M311113200.PMID: 14699128.
27. Rajakumar, K., de las Heras, J., Lee, S., Holick, M.F., and Arslanian, S.A. 2012. 25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care, 35(3): 627-633.doi:10.2337/dc11-1825.PMID:22238280.
28. Teegarden, D., and Donkin, S.S. 2009. Vitamin D: emerging new roles in insulin sensitivity. Nutr. Res. Rev. 22(01): 82-92.doi:10.1017/S0954422409389301. PMID:19555519.
29. Vaidya, A., Forman, J.P., Underwood, P.C., Hopkins, P.N., Williams, G.H., Pojoga, L.H., et al. 2011. The influence of body mass index and reninangiotensin- aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in caucasian men. Eur. J. Endocrinol. 164: 995-1002.doi:10.1530/eje-11-0025.PMID:21402748.
30. Vaidya, A., Williams, J.S., and Forman, J.P. 2012. The independent association between 25-hydroxyvitamin D and adiponectin and its relation with BMI in two large cohorts: The NHS and the HPFS. Obesity, 20(1): 186-191.doi:10.1038/ oby.2011.210.PMID:21760630.
31. Vilarrasa, N., Vendrell, J., Maravall, J., Elio, I., Solano, E., SanJose, P., Garcia, I., Virgili, N., Soler, J., and Gomez, J.M. 2010. Is plasma 25(OH)D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population? Endocrine, 28(2): 235-242.doi: 10.1007/s12020-010-9379-4.PMID:21046484.
32. Wehmeier, K.R., Alamir, A.-R., Sultan, S., Haas, M.J., Wong, N.C.W., and Mooradian, A.D. 2011. 24,25-Dihydroxycholecalciferol but not 25- hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 88(1-2): 110-116.doi:10.1016/j.lfs.2010.11.005.PMID:21062631.
33. Whitehead, J.P., Richards, A.A., Hickman, I.J., MacDonald, G.A., and Prins, J.B. 2006. Adiponectin - a key adipokine in the metabolic syndrome. Diabetes Obes. Metab. 8: 264-280.doi:10.1111/j.1463-1326.2005.00510.x.PMID:16634986.
34. WHO. 2006. Guidelines for the prevention, management and care of diabetes mellitus. EMRO Technical Publications Series No. 32.