Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation

Behavioural Brain Research

Volumn 228, Issue 1, 2012, Pages 151-158

  Jobim, Paulo F C ^a,b,c   Pedroso, Thiago R ^a,b,c   Werenicz, Aline ^a,b,c   Christoff, Raissa R ^a,b,c   Maurmann, Natasha ^a,b,c   Reolon, Gustavo K ^a,b,c   Schröder, Nadja ^c,d   Roesler, Rafael ^a,b,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c National Institute for Translational Medicine INCT TM   (Brazil)

^d PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Amygdala; Hippocampus; MTOR; Rapamycin; Recognition memory

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL AMYGDALA; BRAIN REGION; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING; MALE; MEMORY CONSOLIDATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; SIGNAL TRANSDUCTION; TRAINING;

AMYGDALA; ANIMALS; ENZYME INHIBITORS; HIPPOCAMPUS; LEARNING; MALE; MENTAL RECALL; MICROINJECTIONS; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY); RETENTION (PSYCHOLOGY); SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84155173414     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.12.004     Document Type: Article

References (32)

1. McGaugh J.L. The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci 2004, 27:1-28.
2. Ennaceur A., Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data. Behav Brain Res 1988, 31:47-59.
3. Dornelles A., de Lima M.N., Grazziotin M., Presti-Torres J., Garcia V.A., Scalco F.S., et al. Adrenergic enhancement of consolidation of object recognition memory. Neurobiol Learn Mem 2007, 88:137-142.
4. Okuda S., Roozendaal B., McGaugh J.L. Glucocorticoid effects on object recognition memory require training-associated emotional arousal. Proc Natl Acad Sci USA 2004, 101:853-858.
5. Roozendaal B., Castello N.A., Vedana G., Barsegyan A., McGaugh J.L. Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memory. Neurobiol Learn Mem 2008, 90:576-579.
6. Roozendaal B., Okuda S., Van der Zee E.A., McGaugh J.L. Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala. Proc Natl Acad Sci USA 2006, 103:6741-6746.
7. Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
8. Guertin D.A., Sabatini D.M. The pharmacology of mTOR inhibition. Sci Signal 2009, 2:e24.
9. Hoeffer C.A., Klann E. mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci 2010, 33:67-75.
10. Bekinschtein P., Katche C., Slipczuk L.N., Igaz L.M., Cammarota M., Izquierdo I., et al. mTOR signaling in the hippocampus is necessary for memory formation. Neurobiol Learn Mem 2007, 87:303-307.
11. Blundell J., Kouser M., Powell C.M. Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation. Neurobiol Learn Mem 2008, 90:28-35.
12. Gafford G.M., Parsons R.G., Helmstetter F.J. Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus. Neuroscience 2011, 182:98-104.
13. Glover E.M., Ressler K.J., Davis M. Differing effects of systemically administered rapamycin on consolidation and reconsolidation of context vs. cued fear memories. Learn Mem 2010, 17:577-581.
14. Jobim P.F., Pedroso T.R., Christoff R.R., Werenicz A., Maurmann N., Reolon G.K., et al. Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory. Neurobiol Learn Mem 2011, 10.1016/j.nlm.2011.10.002.
15. Parsons R.G., Gafford G.M., Helmstetter F.J. Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. J Neurosci 2006, 26:12977-12983.
16. Slipczuk L., Bekinschtein P., Katche C., Cammarota M., Izquierdo I., Medina J.H. BDNF activates mTOR to regulate GluR1 expression required for memory formation. PLoS One 2009, 4:e6007.
17. Myskiw J.C., Rossato J.I., Bevilaqua L.R., Medina J.H., Izquierdo I., Cammarota M. On the participation of mTOR in recognition memory. Neurobiol Learn Mem 2008, 89:338-351.
18. Roesler R., Schröder N., Vianna M.R., Quevedo J., Bromberg E., Kapczinski F., et al. Differential involvement of hippocampal and amygdalar NMDA receptors in contextual and aversive aspects of inhibitory avoidance memory in rats. Brain Res 2003, 975:207-213.
19. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2007, Academic Press, San Diego. 6th ed.
20. de Lima M.N., Presti-Torres J., Garcia V.A., Guimarães M.R., Scalco F.S., Roesler R., et al. Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats. Neuropharmacology 2008, 55:788-792.
21. Reolon G.K., Maurmann N., Werenicz A., Garcia V.A., Schröder N., Wood M.A., et al. Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats. Behav Brain Res 2011, 221:329-332.
22. de Lima M.N., Luft T., Roesler R., Schröder N. Temporary inactivation reveals an essential role of the dorsal hippocampus in consolidation of object recognition memory. Neurosci Lett 2006, 405:142-146.
23. Mendoza M.C., Er E.E., Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci 2011, 36:320-328.
24. Lin C.H., Yeh S.H., Lin C.H., Lu K.T., Leu T.H., Chang W.C., et al. A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 2001, 31:841-851.
25. Walz R., Roesler R., Quevedo J., Sant'Anna M.K., Madruga M., Rodrigues C., et al. Time-dependent impairment of inhibitory avoidance retention in rats by posttraining infusion of a mitogen-activated protein kinase kinase inhibitor into cortical and limbic structures. Neurobiol Learn Mem 2000, 73:11-20.
26. Yecies J.L., Manning B.D. mTOR links oncogenic signaling to tumor cell metabolism. J Mol Med 2011, 89:221-228.
27. Broadbent N.J., Gaskin S., Squire L.R., Clark R.E. Object recognition memory and the rodent hippocampus. Learn Mem 2009, 17:5-11.
28. Gaskin S., Tremblay A., Mumby D.G. Retrograde and anterograde object recognition in rats with hippocampal lesions. Hippocampus 2003, 13:962-969.
29. Rampon C., Tang Y.P., Goodhouse J., Shimizu E., Kyin M., Tsien J.Z. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci 2000, 3:238-244.
30. Amaral O.B., Osan R., Roesler R., Tort A.B. A synaptic reinforcement-based model for transient amnesia following disruptions of memory consolidation and reconsolidation. Hippocampus 2008, 18:584-601.
31. Alberini C.M. The role of reconsolidation and the dynamic process of long-term memory formation and storage. Front Behav Neurosci 2011, 5:12.
32. Dudai Y., Eisenberg M. Rites of passage of the engram: reconsolidation and the lingering consolidation hypothesis. Neuron 2004, 44:93-100.