Suppressive effect of ascorbic acid on the mutagenesis induced by the bystander effect through mitochondrial function

Free Radical Research

Volumn 47, Issue 6-7, 2013, Pages 474-479

  Kashino, Genro ^a   Tamari, Y ^b   Kumagai, J ^c   Tano, K ^b   Watanabe, M ^b  

^a OITA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

Author keywords

Ascorbic acid; Bystander effect; Ionizing radiation; Mitochondria; Mutagenesis

Indexed keywords

ASCORBIC ACID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; BYSTANDER EFFECT; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; GENE; GENE OVEREXPRESSION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; RADIATION MUTAGENESIS; SOD2 GENE; X IRRADIATION;

ANIMALS; ASCORBIC ACID; BYSTANDER EFFECT; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MUTAGENESIS; PERMEABILITY; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

MAMMALIA;

EID: 84878856403     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2013.791025     Document Type: Article

References (26)

1. Iyer R, Lehnert BE, Svensson R. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 2000; 60 : 1290-1298.
2. Barcellos-Hoff MH, Brooks AL. Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander eff ects, and genomic instability. Radiat Res 2001; 156: 618- 627.
3. Ivanov VN, Zhou H, Ghandhi SA, Karasic TB, Yaghoubian B, Amundson SA, Hei TK. Radiation-induced bystander signaling pathways in human fi broblasts: a role for interleukin-33 in the signal transmission. Cell Signal 2010; 22 : 1076-1087.
4. Pasi F, Facoetti A, Nano R. IL-8 and IL-6 bystander signalling in human glioblastoma cells exposed to gamma radiation. Anticancer Res 2010; 30 : 2769-2772.
5. Kashino G, Prise KM, Schettino G, Folkard M, Vojnovic B, Michael BD, et al. Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. Mutat Res 2004; 556 : 209-215.
6. Nagasawa H, Huo L, Little JB. Increased bystander mutagenic eff ect in DNA double-strand break repair-defi cient mammalian cells. Int J Radiat Biol 2003; 79 : 35-41.
7. Yang H, Asaad N, Held KD. Medium-mediated intercellular communication is involved in bystander responses of Xray- irradiated normal human fi broblasts. Oncogene 2005; 24 : 2096-2103.
8. Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, et al. Mechanism of radiation-induced bystander eff ect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci USA 2005; 102 : 14641-14646.
9. Sagun KC, Carcamo JM, Golde DW. Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut 1) and confers mitochondrial protection against oxidative injury. FASEB J 2005; 19 : 1657-1667.
10. Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A, et al. Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2. Biochem Biophys Res Commun 2009; 379 : 233-238.
11. Nishiura H, Kumagai J, Kashino G, Okada T, Tano K, Watanabe M. The bystander eff ect is a novel mechanism of UVA-induced melanogenesis. Photochem Photobiol 2012; 88 : 389-397.
12. Kashino G, Suzuki K, Matsuda N, Kodama S, Ono K, Watanabe M, Prise KM. Radiation induced bystander signals are independent of DNA damage and DNA repair capacity of the irradiated cells. Mutat Res 2007; 619 : 134-138.
13. Kashino G, Prise KM, Suzuki K, Matsuda N, Kodama S, Suzuki M, et al. Eff ective suppression of bystander eff ects by DMSO treatment of irradiated CHO cells. J Radiat Res 2007; 48 : 327-333.
14. Kodama S, Kashino G, Suzuki K, Takatsuji T, Okumura Y, Oshimura M, et al. Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8. Cancer Res 1998; 58 : 5188-5195.
15. Kinashi Y, Masunaga S, Nagata K, Suzuki M, Takahashi S, Ono K. A bystander eff ect observed in boron neutron capture therapy: a study of the induction of mutations in the HPRT locus. Int J Radiat Oncol Biol Physic 2007; 66 : 1515-1522.
16. Hosoki A, Yonekura S, Zhao QL, Wei ZL, Takasaki I, Tabuchi Y, et al. Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells. J Radiat Res 2012; 53 : 58-71.
17. Tamari Y, Nawata H, Inoue E, Yoshimura A, Yoshii H, Kashino G, et al. Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells. Free Radic Res 2013; 47: 1- 7.
18. Müller K, Meineke V. Radiation-induced alterations in cytokine production by skin cells. Exp Hematol 2007; 35 : 96-104.
19. Neta R. Modulation of radiation damage by cytokines. Stem Cells 1997; 15 : 87-94.
20. Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, et al. Induction of radioresistance by a nitric oxide-mediated bystander eff ect. Radiat Res 2001; 155: 387-396.
21. Tsukimoto M, Homma T, Ohshima Y, Kojima S. Involvement of purinergic signaling in cellular response to gamma radiation. Radiat Res 2010; 173: 298- 309.
22. Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C. The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander eff ects. Radiat Res 2006; 165 : 400-409.
23. Nugent S, Mothersill CE, Seymour C, McClean B, Lyng FM, Murphy JE. Altered mitochondrial function and genome frequency post exposure to © -radiation and bystander factors. Int J Radiat Biol 2010; 86 : 829-841.
24. Huo L, Nagasawa H, Little JB. HPRT mutants induced in bystander cells by very low fl uences of alpha particles result primarily from point mutations. Radiat Res 2001; 156 : 521-525.
25. Yang H, Asaad N, Held KD. Medium-mediated intercellular communication is involved in bystander responses of Xray- irradiated normal human fi broblasts. Oncogene 2005; 24 : 2096-2103.
26. Koyama S, Kodama S, Suzuki K, Matsumoto T, Miyazaki T, Watanabe M. Radiation-induced long-lived radicals which cause mutation and transformation. Mutat Res 1998; 421 : 45-54.