The association of luteinizing hormone and follicle-stimulating hormone with cytokines and markers of disease activity in rheumatoid arthritis: A casecontrol study

Scandinavian Journal of Rheumatology

Volumn 39, Issue 2, 2010, Pages 109-117

  Kass A S ^a   Lea, T E ^b   Torjesen, P A ^c   Gulseth, H C ^a   Forre O T ^d  

^a Betanien Hospital   (Norway)

^b NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^c AKER UNIVERSITY HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CXCL9 CHEMOKINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; EOTAXIN; FOLLITROPIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; LUTEINIZING HORMONE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FOLLITROPIN BLOOD LEVEL; HEALTH ASSESSMENT QUESTIONNAIRE; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; VISUAL ANALOG SCALE;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOKINES; FEMALE; FLUOROIMMUNOASSAY; FOLLICLE STIMULATING HORMONE; HUMANS; LUTEINIZING HORMONE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PAIN; PAIN MEASUREMENT; PATIENT SELECTION; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX;

EID: 77950256741     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.3109/03009740903270607     Document Type: Article

References (29)

1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-361
2. Ostensen M, Aune B, Husby G. Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis. Scand J Rheumatol 1983;12:69-72.
3. Rudge SR, Kowanko IC, Drury PL. Menstrual cyclicity of finger joint size and grip strength in patients with rheumatoid arthritis. Ann Rheum Dis 1983;42:425-430
4. Silman A, Kay A, Brennan P. Timing of pregnancy in relation to the onset of rheumatoid arthritis. Arthritis Rheum 1992; 35:152-155
5. Goemaere S, Ackerman C, Goethals K, De Keyser F, Van der Straeten C, Verbruggen G, et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol 1990;17:1620-1622
6. Kendall MD. Functional anatomy of the thymic microenvironment. J Anat 1991;177:1-29.
7. Maier CC, Marchetti B, LeBoeuf RD, Blalock JE. Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA. Cell Mol Neurobiol 1992; 12:447-454
8. Cutolo M, Accardo S, Villaggio B, Barone A, Sulli A, Coviello DA, et al. Androgen and estrogen receptors are present in primary cultures of human synovial macrophages. J Clin Endocrinol Metab 1996;81:820-827
9. Araneo BA, Dowell T, Diegel M, Daynes RA. Dihydrotestosterone exerts a depressive influ ence on the production of interelukin-4 (IL-4), IL-5, and g-interferon, but not IL-2 by activated murine T cells. Blood 1991;78:688-699
10. Gilmore W, Weiner L, Correale J. Effect of estradiol on cytokine secretion by proteolipid protein specific T cell clones isolated from multiple sclerosis patients and normal control subjects. J Immunol 1997;158:446-451
11. Piccinni M-P, Giudizi M-G, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, et al. Progesterone favours the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995;155: 128-133
12. Dalal M, Kim S, Voskuhl R. Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in autoantigen-specific T lymphocyte response. J Immunol 1997;159:3-6.
13. Kanda N, Tsuchida T, Tamaki K. Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells. Clin Exp Immunol 1996;106:410-415
14. Verthelyi D, Ansar Ahmed S. 17b-estradiol, but not 5a- dihydrotestosterone, augments antibodies to double-stranded deoxyribonucleic acid in nonautoimmune C57BL/6J mice. Endocrinology 1994;135:2615-2622
15. Sabharwal P, Varma S, Malarkey WB. Human thymocytes secrete luteinizing hormone: an autocrine regulator of T cell proliferation. Biochem Biophys Res Commun 1992;187: 1187-1192
16. Athreya BH, Pletcher J, Zulian F, Weiner DB, Williams WV. Subset-specific effects of sex hormones and pituitary gonadotropins on human lymphocyte proliferation in vitro. Clin Immunol Immunopathol 1993;66:201-211
17. Iqbal J, Sun Li, Kumar TR, Blair HC, Zaidi M. Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci 2006; 103:14925-14930
18. Mowinckel P, Hagen KB, Heiberg T, Kvien TK. Repeated measures in rheumatoid arthritis reduced the required sample size in a two-armed clinical trial. J Clin Epidemiol 2008;61:940-944
19. Arnett FC, Edworthy SM, Bloch D, McShane DJ, Fries JF, Cooer NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-324
20. Pincus T, Summey JA, Soraci SA Jr, Wallston KA, Hummon NP. Assessment of patient satisfaction in activities of daily living using a modified Stanford Health Assessment Questionnaire. Arthritis Rheum 1983;26:1346-1353
21. Prevoo ML, van't Hof MA, Kuper HH, Van Leeuwen MA, Van De Putte LB, Van Riel PL. Modified disease activity scores that incluDe twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:44-48
22. De Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003;10:133-139
23. Chae S-C, Park Y-R, Shim S-C, Lee I-K, Chung H-T. Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population. Hum Immunol 2005;66:314-320
24. Gordon B, Beastall GH, Thomson JA, Sturrock RD. Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease activity. Br J Rheumatol 1988;27:440-444
25. Raza K, Falciani F, Curnow SJ, Ross EJ, Lee C-Y, Akbar AN, et al. Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther 2005;7:R784-95.
26. Feldman M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Ann Rev Immunol 1996;14:397-440.
27. Cutolo M, Balleari E, Giusti M, Monachesi M, Accardo S. Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation. Arthritis Rheum 1988;31:1314-1317
28. Tengstrand B, Carlstrom K, Hafstrom I. Bioavailable testosterone in men with rheumatoid arthritis: high frequency of hypogonadism. Rheumatology 2002;41:285-289
29. Gordon D, Beastall GH, Thomson JA, Sturrock RD. Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis. QJ Med 1986;60:671-679