Crystal structures of the viral protease Npro imply distinct roles for the catalytic water in catalysis

Structure

Volumn 21, Issue 6, 2013, Pages 929-938

  Zögg, Thomas ^a,b   Sponring, Michael ^b,c,d   Schindler, Sabrina ^b,c   Koll, Maria ^b,c,d   Schneider, Rainer ^b,c   Brandstetter, Hans ^a,b   Auer, Bernhard ^b,c  

^a UNIVERSITY OF SALZBURG   (Austria)

^b AUSTRIAN CENTRE OF INDUSTRIAL BIOTECHNOLOGY   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; PROTEASE NPRO; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; BINDING SITE; BOVINE DIARRHEA VIRUS; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; ENZYME MODIFICATION; ENZYME SUBSTRATE; IONIC STRENGTH; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE;

BINDING SITES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; PROTEIN CONFORMATION; PROTEOLYSIS; STATIC ELECTRICITY; VIRAL PROTEINS; WATER;

BOVINE VIRAL DIARRHEA VIRUS 1;

EID: 84878844202     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.04.003     Document Type: Article

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