Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

Lipids in Health and Disease

Volumn 11, Issue , 2012, Pages

  Monteiro, Jessica ^a   Li, Feng Jun ^a   MacLennan, Mira ^a   Rabalski, Alexandra ^a   Moghadasian, Mohammed H ^b   Nakamura, Manabu T ^c   Ma, David W L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Alpha linolenic acid; Delta 5 desaturase; Delta 6 desaturase knock out; HUFA; Knock out; Linoleic acid; Liver

Indexed keywords

ACYL COENZYME A DESATURASE 1; ARACHIDONIC ACID; LINOLEIC ACID; LINOLENIC ACID; LINOLEOYL COENZYME A DESATURASE; MENHADEN OIL; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; SAFFLOWER OIL; SOYBEAN OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; KNOCKOUT MOUSE; LIPID COMPOSITION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PHOSPHOLIPID BLOOD LEVEL; WILD TYPE;

ALPHA-LINOLENIC ACID; ANIMALS; FATTY ACID DESATURASES; FISH OILS; LINOLEIC ACID; LINOLEOYL-COA DESATURASE; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHOLIPIDS; SAFFLOWER OIL; SOYBEAN OIL;

CARTHAMUS TINCTORIUS; GLYCINE MAX; MUS;

EID: 84861472018     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-11-60     Document Type: Article

References (37)

1. Essential fatty acid synthesis and its regulation in mammals. Nakamura MT, Nara TY, Prostaglandins Leukot Essent Fatty Acids 2003 68 145 150 10.1016/S0952-3278(02)00264-8 12538078 (Pubitemid 36216478)
2. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. Cho HP, Nakamura MT, Clarke SD, J Biol Chem 1999 274 471 477 10.1074/jbc.274.1.471 9867867 (Pubitemid 29035085)
3. Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. Clarke SD, Am J Physiol Gastrointest Liver Physiol 2001 281 865 G869 11557505
4. A preliminary note on the examination of the fat in the liver in health and disease. Kennaway EL, Leathes JB, Proc R Soc Med 1909 2 136 144 20898035
5. Liver lipid metabolism. Nguyen P, Leray V, Diez M, Serisier S, Le BJ, Siliart B, et al. J Anim Physiol Anim Nutr (Berl) 2008 92 272 283 10.1111/j.1439-0396.2007.00752.x (Pubitemid 351670169)
6. A new deficiency disease produced by the rigid exclusion of fat from the diet. Burr GO, Burr MM, J Biol Chem 1929 82 345 367 Ref Type: Generic
7. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Nakamura MT, Nara TY, Annu Rev Nutr 2004 24 345 376 10.1146/annurev.nutr.24.121803.063211 15189125 (Pubitemid 38938796)
8. Bioactive dietary long-chain fatty acids: emerging mechanisms of action. Chapkin RS, McMurray DN, Davidson LA, Patil BS, Fan YY, Lupton JR, Br J Nutr 2008 100 1152 1157 10.1017/S0007114508992576 18492298
9. Incorporation of dietary [14C]arachidonic acid and [3H]eicosapentaenoic acid into tissue lipids during absorption of a fish oil emulsion. Nilsson A, Hjelte L, Strandvik B, J Lipid Res 1992 33 1295 1305 1402398
10. DHA metabolism: targeting the brain and lipoxygenation. Picq M, Chen P, Perez M, Michaud M, Vericel E, Guichardant M, et al. Mol Neurobiol 2010 42 48 51 10.1007/s12035-010-8131-7 20422316
11. Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease. Bemelmans WJ, Muskiet FA, Feskens EJ, de Vries JH, Broer J, May JF, et al. Eur J Clin Nutr 2000 54 865 871 10.1038/sj.ejcn.1601102 11114683 (Pubitemid 32036940)
12. Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the multiple risk factor intervention trial. Dolecek TA, Proc Soc Exp Biol Med 1992 200 177 182 1579579
13. Flaxseed oil reduces the growth of human breast tumors (MCF-7) at high levels of circulating estrogen. Truan JS, Chen JM, Thompson LU, Mol Nutr Food Res 2010 54 1414 1421 10.1002/mnfr.200900521 20425756
14. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. Moriguchi T, Loewke J, Garrison M, Catalan JN, Salem N, J Lipid Res 2001 42 419 427 11254754 (Pubitemid 32270066)
15. Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice. Roqueta-Rivera M, Stroud CK, Haschek WM, Akare SJ, Segre M, Brush RS, et al. J Lipid Res 2010 51 360 367 10.1194/jlr.M001180 19690334
16. Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. Stoffel W, Holz B, Jenke B, Binczek E, Gunter RH, Kiss C, et al. EMBO J 2008 27 2281 2292 10.1038/emboj.2008.156 19172737
17. Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration. Stroud CK, Nara TY, Roqueta-Rivera M, Radlowski EC, Lawrence P, Zhang Y, et al. J Lipid Res 2009 50 1870 1880 10.1194/jlr.M900039-JLR200 19351970
18. Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid. Rosenblat M, Volkova N, Roqueta-Rivera M, Nakamura MT, Aviram M, Atherosclerosis 2010 210 414 421 10.1016/j. atherosclerosis.2009.11.044 20042190
19. Omega-3 fatty acids in health and disease and in growth and development. Simopoulos AP, Am J Clin Nutr 1991 54 438 463 1908631 (Pubitemid 21898954)
20. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Simopoulos AP, Exp Biol Med (Maywood) 2008 233 674 688 10.3181/0711-MR-311
21. A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance. Smith BK, Holloway GP, Reza-Lopez S, Jeram SM, Kang JX, Ma DW, Appl Physiol Nutr Metab 2010 35 699 706 10.1139/H10-066 20962926
22. Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes. Xia SH, Wang J, Kang JX, Carcinogenesis 2005 26 779 784 10.1093/carcin/bgi019 15661810 (Pubitemid 41214340)
23. Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults. Merino DM, Johnston H, Clarke S, Roke K, Nielsen D, Badawi A, et al. Mol Genet Metab 2011 103 171 178 10.1016/j.ymgme.2011.02.012 21414826
24. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Schaeffer L, Gohlke H, Muller M, Heid IM, Palmer LJ, Kompauer I, et al. Hum Mol Genet 2006 15 1745 1756 10.1093/hmg/ddl117 16670158 (Pubitemid 43821765)
25. Alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. Baylin A, Ruiz-Narvaez E, Kraft P, Campos H, Am J Clin Nutr 2007 85 554 560 17284757 (Pubitemid 46220962)
26. Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? Truong H, DiBello JR, Ruiz-Narvaez E, Kraft P, Campos H, Baylin A, Am J Clin Nutr 2009 89 920 925 10.3945/ajcn.2008.27107 19144731
27. Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism. Lattka E, Illig T, Koletzko B, Heinrich J, Curr Opin Lipidol 2010 21 64 69 10.1097/MOL.0b013e3283327ca8 19809313
28. Remodeling of arachidonate-containing phosphoglycerides within the human neutrophil. Chilton FH, Murphy RC, J Biol Chem 1986 261 7771 7777 3086318 (Pubitemid 17208700)
29. Rapid remodeling of arachidonate from phosphatidylcholine to phosphatidylethanolamine pools during mast cell activation. Fonteh AN, Chilton FH, J Immunol 1992 148 1784 1791 1541818
30. Acyl coenzyme a:phospholipid acyltransferases in porcine platelets discriminate between omega-3 and omega-6 unsaturated fatty acids. Inoue M, Murase S, Okuyama H, Arch Biochem Biophys 1984 231 29 37 10.1016/0003-9861(84) 90359-X 6721500 (Pubitemid 14139900)
31. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. Xu J, Nakamura MT, Cho HP, Clarke SD, J Biol Chem 1999 274 23577 23583 10.1074/jbc.274.33.23577 10438539 (Pubitemid 29388116)
32. The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids. Nara TY, He WS, Tang C, Clarke SD, Nakamura MT, Biochem Biophys Res Commun 2002 296 111 117 10.1016/S0006-291X(02)00851-3 12147235 (Pubitemid 35002063)
33. Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha. Matsuzaka T, Shimano H, Yahagi N, memiya-Kudo M, Yoshikawa T, Hasty AH, et al. J Lipid Res 2002 43 107 114 11792729 (Pubitemid 34117224)
34. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. Yahagi N, Shimano H, Hasty AH, Memiya-Kudo M, Okazaki H, Tamura Y, et al. J Biol Chem 1999 274 35840 35844 10.1074/jbc.274.50.35840 10585468 (Pubitemid 129512889)
35. Deficiency in the omega-3 fatty acid pathway results in failure of acrosome biogenesis in mice. Roqueta-Rivera M, Abbott TL, Sivaguru M, Hess RA, Nakamura MT, Biol Reprod 2011
36. A simple method for the isolation and purification of total lipides from animal tissues. Folch J, Lees M, Sloane Stanley GH, J Biol Chem 1957 226 497 509 13428781
37. Fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids. Lau BY, Ward WE, Kang JX, Ma DW, Appl Physiol Nutr Metab 2010 35 447 455 10.1139/H10-029 20725110