Effect of diphlorethohydroxycarmalol isolated from ishige okamurae on apoptosis in 3 t3-L1 preadipocytes

Phytotherapy Research

Volumn 27, Issue 6, 2013, Pages 931-936

  Park, Mi Hwa ^a   Jeon, You Jin ^b   Kim, Hak Ju ^c   Han, Ji Sook ^a  

^a Pusan National University   (South Korea)

^b Jeju National University   (South Korea)

^c Seojin Biotech Co Ltd   (South Korea)

Author keywords

3 T3 L1 preadipocytes; antiobesity; apoptosis; diphlorethohydroxycarmalol

Indexed keywords

ALGAL EXTRACT; ANTIOBESITY AGENT; CASPASE 3; CASPASE 9; DIPHLORETHOHYDROXYCARMALOL; HISTONE DEACETYLASE; ISHIGE OKAMURAE EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BROWN ALGA; CELL COUNT; CELL GROWTH; CELL POPULATION; CELL STRAIN; CELL STRAIN 3 T3 L1; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; ISHIGE OKAMURAE; MOUSE; NONHUMAN; PROADIPOCYTE; PROTEIN CLEAVAGE;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL PROLIFERATION; HETEROCYCLIC COMPOUNDS, 3-RING; MICE; PHAEOPHYTA; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2;

ISHIGE OKAMURAE;

EID: 84878831161     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4797     Document Type: Article

References (21)

1. Bray GA, Tartaglia LA,. 2000. Medicinal strategies in the treatment of obesity. Nature 404: 672-677.
2. Formiguera X, Canton A,. 2004. Obesity: epidemiology and clinical aspects. Best Pract Res Clin Gastroenterol 18: 1125-1146.
3. Furuyashiki T, Nagayasu H, Aoki Y, Bessho H, et al,. 2004. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARγ2 and C/EBPα in 3 T3-L1 cells. Biosci Biotechnol Biochem 68: 2353-2359.
4. Gajewski TF, Thompson CB,. 1996. Cell 87: 589-592.
5. Green H, Kehinde O,. 1974. Sublines of mouse 3 T3 cells that accumulate lipid. Cell 1: 113-116.
6. Heo SJ, Kim JP, Jung WK, Lee NH, Kang HS, Jun EM, Park SH, Kang SM, Lee YJ, Park PJ, Jeon YJ,. 2008. Identification of chemical structure and free radical scavenging activity of diphlorethohydroxycarmalol isolated from a brown alga, Ishige okamurae. J Microbiol Biotechnol 18: 676-681.
7. Kessler RC, Davis RB, Foster DF, et al,. 2001. Long-term trends in the use of complementary and alternative medical therapies in the United States. Ann Intern Med 135: 262-268.
8. Kopelman PG,. 2000. Obesity as a medical problem. Nature 404: 635-643.
9. Lee IK, Kang JW,. 1986. A check list of marine algae in Korea. Algae 1: 311-325.
10. Mayter AMS, Hamann MT,. 2005. Marine pharmacology in 2001-2002: marine compounds with anthelmintic, antibacterial, anticoaglulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, anti-tuberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comp Biochem Physiol C 140: 265-286.
11. Nagata S, Golstein P,. 1995. The Fas death factor. Science (Washington, DC, U.S.) 267: 1449-1456.
12. Proter AG, Janicke RU,. 1999. Emerging roles of caspase-3 on apoptosis. Cell Death Differ 6: 99-104.
13. Rao L, White E,. 1997. Bcl-2 and the ICE family of apoptotic regulators: making a connection. Curr Opin Gen Dev 7: 52-58.
14. Rayalam S, Della-Fera MA, Baile CA,. 2008. Phytochemicals and regulation of the adipocyte cycle. J Nutr Biochem 19: 717-726.
15. Rosato RR, Grant S,. 2003. Histone deacetylase inhibitors in cancer therapy. Cancer Biol Ther 2: 30-37.
16. Shibata T, Fujimoto K, Nagayama K, Yamaguchi K, Nakamura T,. 2002. Inhibitory activity of brown algal phlorotannins against hyaluronidase. Int J Food Sci. Technol 37: 703-709.
17. Vermes I, Haancn C, Steffens-Nakken H, Reutelingsperger C,. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51.
18. Wang YW, Jones PJ,. 2004. Conjugated linolic acid and obesity control: efficacy and mechanisms. Int J Obes Relat Metab Disord 28: 941-955.
19. Weisberg SP, Leibel R, Tortoriello DV,. 2008. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 149 (7): 3549-3558.
20. Wu BT, Hung PF, Chen HC, Huang RN, Chang HH, Kao YH,. 2005. The apoptotic effect of green tea (-)-epigallocatechin gallate on 3 T3-L1 preadipocytes depends on the Cdk2 pathway. J Agric Food Chem 53: 5695-5701.
21. Yang WM, Yao YL, Sun JM, Davie JR, Seto E,. 1997. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem 272: 28001-28007.