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Volumn 14, Issue 10, 2013, Pages 1399-1408

Dutasteride for the treatment of benign prostatic hyperplasia

Author keywords

5 reductase inhibitor; Benign prostatic hyperplasia; Dutasteride; Pharmacodynamics; Pharmacokinetics; Therapeutic use; Tolerability

Indexed keywords

ANDROSTANOLONE; DOXAZOSIN; DUTASTERIDE; DUTASTERIDE PLUS TAMSULOSIN; FINASTERIDE; PLACEBO; TAMSULOSIN; TESTOSTERONE;

EID: 84878827885     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2013.797965     Document Type: Article
Times cited : (25)

References (35)
  • 1
    • 33847239396 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia: An overview
    • Roehrborn CG. Benign prostatic hyperplasia: an overview. Rev Urol 2005;7(Suppl 9):S3-S14
    • (2005) Rev Urol , vol.7 , Issue.SUPPL. 9
    • Roehrborn, C.G.1
  • 2
    • 0031761149 scopus 로고    scopus 로고
    • Population-based studies of the epidemiology of benign prostatic hyperplasia
    • Girman CJ. Population-based studies of the epidemiology of benign prostatic hyperplasia. Br J Urol 1998;82(Suppl 1):34-43
    • (1998) Br J Urol , vol.82 , Issue.SUPPL. 1 , pp. 34-43
    • Girman, C.J.1
  • 3
    • 0021149603 scopus 로고
    • The development of human benign prostatic hyperplasia with age
    • Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol 1984;132(3):474-9
    • (1984) J Urol , vol.132 , Issue.3 , pp. 474-479
    • Berry, S.J.1    Coffey, D.S.2    Walsh, P.C.3    Ewing, L.L.4
  • 4
    • 79953216653 scopus 로고    scopus 로고
    • Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: A 1-year, open-label extension study
    • Donatucci CF, Brock GB, Goldfischer ER, et al. Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a 1-year, open-label extension study. BJU Int 2011;107(7):1110-16
    • (2011) BJU Int , vol.107 , Issue.7 , pp. 1110-1116
    • Donatucci, C.F.1    Brock, G.B.2    Goldfischer, E.R.3
  • 5
    • 80053308004 scopus 로고    scopus 로고
    • Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: Results of an international randomized, double-blind, placebo-controlled trial
    • Porst H, Kim ED, Casabe AR, et al. Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of an international randomized, double-blind, placebo-controlled trial. Eur Urol 2011;60(5):1105-13
    • (2011) Eur Urol , vol.60 , Issue.5 , pp. 1105-1113
    • Porst, H.1    Kim, E.D.2    Casabe, A.R.3
  • 6
    • 4544285381 scopus 로고    scopus 로고
    • Dihydrotestosterone and the prostate: The scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia
    • Andriole G, Bruchovsky N, Chung LW, et al. Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. J Urol 2004;172(4 Pt 1):1399-403
    • (2004) J Urol , vol.172 , Issue.4 PART 1 , pp. 1399-1403
    • Andriole, G.1    Bruchovsky, N.2    Chung, L.W.3
  • 7
    • 0029831550 scopus 로고    scopus 로고
    • Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat
    • Wright AS, Thomas LN, Douglas RC, et al. Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat. J Clin Invest 1996;98(11):2558-63
    • (1996) J Clin Invest , vol.98 , Issue.11 , pp. 2558-2563
    • Wright, A.S.1    Thomas, L.N.2    Douglas, R.C.3
  • 8
    • 42949151909 scopus 로고    scopus 로고
    • 5alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction
    • Rittmaster RS. 5alpha-reductase inhibitors in benign prostatic hyperplasia and prostate cancer risk reduction. Best Pract Res Clin Endocrinol Metab 2008;22(2):389-402
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , Issue.2 , pp. 389-402
    • Rittmaster, R.S.1
  • 9
    • 0036545464 scopus 로고    scopus 로고
    • Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia
    • Bartsch G, Rittmaster RS, Klocker H. Dihydrotestosterone and the concept of 5alpha-reductase inhibition in human benign prostatic hyperplasia. World J Urol 2002;19(6):413-25
    • (2002) World J Urol , vol.19 , Issue.6 , pp. 413-425
    • Bartsch, G.1    Rittmaster, R.S.2    Klocker, H.3
  • 10
    • 33646435242 scopus 로고    scopus 로고
    • DHT and testosterone, but not dhea or e2, differentially modulate igf-i, igfbp-2, and igfbp-3 in human prostatic stromal cells
    • Le H, Arnold JT, McFann KK, Blackman MR. DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab 2006;290(5):E952-60
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.5
    • Le, H.1    Arnold, J.T.2    McFann, K.K.3    Blackman, M.R.4
  • 11
    • 0028173882 scopus 로고
    • Steroid 5 alpha-reductase: Two genes/two enzymes
    • Russell DW, Wilson JD. Steroid 5 alpha-reductase: two genes/two enzymes. Annu Rev Biochem 1994;63:25-61
    • (1994) Annu Rev Biochem , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 12
    • 0032588595 scopus 로고    scopus 로고
    • Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue
    • Iehle C, Radvanyi F, Gil Diez de Medina S, et al. Differences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue. J Steroid Biochem Mol Biol 1999;68(5-6):189-95
    • (1999) J Steroid Biochem Mol Biol , vol.68 , Issue.5-6 , pp. 189-195
    • Iehle, C.1    Radvanyi, F.2    De Medina Gil Diez, S.3
  • 13
    • 0141988845 scopus 로고    scopus 로고
    • 5alpha-reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium
    • Thomas LN, Douglas RC, Vessey JP, et al. 5alpha-reductase type 1 immunostaining is enhanced in some prostate cancers compared with benign prostatic hyperplasia epithelium. J Urol 2003;170(5):2019-25
    • (2003) J Urol , vol.170 , Issue.5 , pp. 2019-2025
    • Thomas, L.N.1    Douglas, R.C.2    Vessey, J.P.3
  • 14
    • 0141676080 scopus 로고    scopus 로고
    • Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: Implications for finasteride therapy of prostate carcinoma
    • Luo J, Dunn TA, Ewing CM, et al. Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. Prostate 2003;57(2):134-9
    • (2003) Prostate , vol.57 , Issue.2 , pp. 134-139
    • Luo, J.1    Dunn, T.A.2    Ewing, C.M.3
  • 15
    • 0026756111 scopus 로고
    • Prostate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency
    • Imperato-McGinley J, Gautier T, Zirinsky K, et al. Prostate visualization studies in males homozygous and heterozygous for 5 alpha-reductase deficiency. J Clin Endocrinol Metab 1992;75(4):1022-6
    • (1992) J Clin Endocrinol Metab , vol.75 , Issue.4 , pp. 1022-1026
    • Imperato-Mcginley, J.1    Gautier, T.2    Zirinsky, K.3
  • 16
    • 0029932413 scopus 로고    scopus 로고
    • Phenotypic classification of male pseudohermaphroditism due to steroid 5 alpha-reductase 2 deficiency
    • Sinnecker GH, Hiort O, Dibbelt L, et al. Phenotypic classification of male pseudohermaphroditism due to steroid 5 alpha-reductase 2 deficiency. Am J Med Genet 1996;63(1):223-30
    • (1996) Am J Med Genet , vol.63 , Issue.1 , pp. 223-230
    • Sinnecker, G.H.1    Hiort, O.2    Dibbelt, L.3
  • 17
    • 84862301207 scopus 로고    scopus 로고
    • Merck & Co. I. PROSCAR- (finasteride) tablets 5 mg: summary of prescribing information Whitehouse Station, New Jersey, USA; [Cited 13 February 2013]
    • Merck & Co. I. PROSCAR- (finasteride) tablets 5 mg: summary of prescribing information. Merck Sharp & Dohme Corp, Whitehouse Station, New Jersey, USA; 2011. [Cited 13 February 2013]
    • (2011) Merck Sharp & Dohme Corp
  • 18
    • 0006075228 scopus 로고    scopus 로고
    • The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia finasteride long-term efficacy and safety study group
    • McConnell JD, Bruskewitz R, Walsh P, et al. The effect of finasteride on the risk of acute urinary retention and the need for surgical treatment among men with benign prostatic hyperplasia. finasteride long-term efficacy and safety study group. N Engl J Med 1998;338(9):557-63
    • (1998) N Engl J Med , vol.338 , Issue.9 , pp. 557-563
    • McConnell, J.D.1    Bruskewitz, R.2    Walsh, P.3
  • 19
    • 33646127626 scopus 로고    scopus 로고
    • Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor
    • Frye SV. Discovery and clinical development of dutasteride, a potent dual 5alpha-reductase inhibitor. Curr Top Med Chem 2006;6(5):405-21
    • (2006) Curr Top Med Chem , vol.6 , Issue.5 , pp. 405-421
    • Frye, S.V.1
  • 20
    • 0347882750 scopus 로고    scopus 로고
    • The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia
    • McConnell JD, Roehrborn CG, Bautista OM, et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med 2003;349(25):2387-98
    • (2003) N Engl J Med , vol.349 , Issue.25 , pp. 2387-2398
    • McConnell, J.D.1    Roehrborn, C.G.2    Bautista, O.M.3
  • 22
    • 18744424138 scopus 로고
    • Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: Optimization of the c17 substituent
    • Frye SV, Haffner CD, Maloney PR, et al. Structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase by 6-azaandrost-4-en-3-ones: optimization of the C17 substituent. J Med Chem 1995;38(14):2621-7
    • (1995) J Med Chem , vol.38 , Issue.14 , pp. 2621-2627
    • Frye, S.V.1    Haffner, C.D.2    Maloney, P.R.3
  • 23
    • 0028807269 scopus 로고
    • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: Toward perfection of rates of time-dependent inhibition by using ligand-binding energies
    • Tian G, Mook RA Jr, Moss ML, Frye SV. Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies. Biochemistry 1995;34(41):13453-9
    • (1995) Biochemistry , vol.34 , Issue.41 , pp. 13453-13459
    • Tian, G.1    Mook Jr., R.A.2    Moss, M.L.3    Frye, S.V.4
  • 24
    • 0030886845 scopus 로고    scopus 로고
    • Unique preclinical characteristics of gg745, a potent dual inhibitor of 5ar
    • Bramson HN, Hermann D, Batchelor KW, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther 1997;282(3):1496-502
    • (1997) J Pharmacol Exp Ther , vol.282 , Issue.3 , pp. 1496-1502
    • Bramson, H.N.1    Hermann, D.2    Batchelor, K.W.3
  • 25
    • 34249989027 scopus 로고    scopus 로고
    • The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
    • Wurzel R, Ray P, Major-Walker K, et al. The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 2007;10(2):149-54
    • (2007) Prostate Cancer Prostatic Dis , vol.10 , Issue.2 , pp. 149-154
    • Wurzel, R.1    Ray, P.2    Major-Walker, K.3
  • 26
    • 0242331132 scopus 로고    scopus 로고
    • Dutasteride
    • 16; discussion 917-8
    • Evans HC, Goa KL. Dutasteride. Drugs Aging 2003;20(12):905,16; discussion 917-8
    • (2003) Drugs Aging , vol.20 , Issue.12 , pp. 905
    • Evans, H.C.1    Goa, K.L.2
  • 27
    • 0030886845 scopus 로고    scopus 로고
    • Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR
    • Bramson HN, Hermann D, Batchelor KW, et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. J Pharmacol Exp Ther 1997;282(3):1496-502
    • (1997) J Pharmacol Exp Ther , vol.282 , Issue.3 , pp. 1496-1502
    • Bramson, H.N.1    Hermann, D.2    Batchelor, K.W.3
  • 28
    • 0036754256 scopus 로고    scopus 로고
    • Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia
    • Roehrborn CG, Boyle P, Nickel JC, et al. Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. Urology 2002;60(3):434-41
    • (2002) Urology , vol.60 , Issue.3 , pp. 434-441
    • Roehrborn, C.G.1    Boyle, P.2    Nickel, J.C.3
  • 29
    • 4444336295 scopus 로고    scopus 로고
    • Efficacy and safety of long-term treatment with the dual 5 alpha-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia
    • 94; discussion 495
    • Debruyne F, Barkin J, van Erps P, et al. Efficacy and safety of long-term treatment with the dual 5 alpha-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia. Eur Urol 2004;46(4):488,94; discussion 495
    • (2004) Eur Urol , vol.46 , Issue.4 , pp. 488
    • Debruyne, F.1    Barkin, J.2    Van Erps, P.3
  • 30
    • 70449536472 scopus 로고    scopus 로고
    • The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study
    • Roehrborn CG, Siami P, Barkin J, et al. The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol 2010;57(1):123-31
    • (2010) Eur Urol , vol.57 , Issue.1 , pp. 123-131
    • Roehrborn, C.G.1    Siami, P.2    Barkin, J.3
  • 31
    • 0141572168 scopus 로고    scopus 로고
    • Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5alpha-reductase inhibitor dutasteride
    • Barkin J, Guimaraes M, Jacobi G, et al. Alpha-blocker therapy can be withdrawn in the majority of men following initial combination therapy with the dual 5alpha-reductase inhibitor dutasteride. Eur Urol 2003;44(4):461-6
    • (2003) Eur Urol , vol.44 , Issue.4 , pp. 461-466
    • Barkin, J.1    Guimaraes, M.2    Jacobi, G.3
  • 32
    • 79960589121 scopus 로고    scopus 로고
    • Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: The enlarged prostate international comparator study (epics)
    • Nickel JC, Gilling P, Tammela TL, et al. Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: the enlarged prostate international comparator study (EPICS). BJU Int 2011;108(3):388-94
    • (2011) BJU Int , vol.108 , Issue.3 , pp. 388-394
    • Nickel, J.C.1    Gilling, P.2    Tammela, T.L.3
  • 33
    • 0037253614 scopus 로고    scopus 로고
    • Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: The prospective european doxazosin and combination therapy (predict) trial
    • Kirby RS, Roehrborn C, Boyle P, et al. Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the prospective european doxazosin and combination therapy (PREDICT) trial. Urology 2003;61(1):119-26
    • (2003) Urology , vol.61 , Issue.1 , pp. 119-126
    • Kirby, R.S.1    Roehrborn, C.2    Boyle, P.3
  • 34
    • 77950498003 scopus 로고    scopus 로고
    • Effect of dutasteride on the risk of prostate cancer
    • Andriole GL, Bostwick DG, Brawley OW, et al. Effect of dutasteride on the risk of prostate cancer. N Engl J Med 2010;362(13):1192-202
    • (2010) N Engl J Med , vol.362 , Issue.13 , pp. 1192-1202
    • Andriole, G.L.1    Bostwick, D.G.2    Brawley, O.W.3
  • 35
    • 79960210525 scopus 로고    scopus 로고
    • The risks and benefits of 5alpha-reductase inhibitors for prostate-cancer prevention
    • Theoret MR, Ning YM, Zhang JJ, et al. The risks and benefits of 5alpha-reductase inhibitors for prostate-cancer prevention. N Engl J Med 2011;365(2):97-9
    • (2011) N Engl J Med , vol.365 , Issue.2 , pp. 97-99
    • Theoret, M.R.1    Ning, Y.M.2    Zhang, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.