Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat

Journal of Clinical Investigation

Volumn 98, Issue 11, 1996, Pages 2558-2563

  Wright, A Stuart ^a   Thomas, Lynn N ^a   Douglas, Robert C ^a   Lazier, Catherine B ^a   Rittmaster, Roger S ^a,b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b Gerald Hall ^*  (Canada)

Author keywords

dose response relationship drug; finasteride pharmacology; gene expression regulation; histocytochemistry methods; oxidoreductases antagonists and inhibitors

Indexed keywords

ANDROSTANOLONE; FINASTERIDE; TESTOSTERONE;

APOPTOSIS; ARTICLE; CASTRATION; DNA DEGRADATION; DOSE RESPONSE; DRUG POTENCY; GENE EXPRESSION REGULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTATE DISEASE; RAT;

EID: 0029831550     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119074     Document Type: Article

References (28)

1. Grino, P.B., J.E. Griffin, and J.D. Wilson. 1990. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology. 126:1165-1172.
2. Deslypere, J.-P., M. Young, J.D. Wilson, and M.J. McPhaul. 1992. Testosterone and 5α-dihydrotestosterone interact differently with the androgen receptor to enhance transcription of the MMTV-CAT reporter gene. Mol. Cell. Endocrinol. 88:15-22.
3. Lamb, J.C., H. English, P.L. Levandoski, G.R. Rhodes, R.K. Johnson, and J.T. Isaacs. 1992. Prostatic involution in rats induced by a novel 5α-reductase inhibitor, SK&F 105657; role for testosterone in the androgenic response. Endocrinology. 130:685-694.
4. Imperato-McGinley, J., T. Gautier, K. Zirinsky, T. Hem, O. Palomo, E. Stein, E.D. Vaughan, J.A. Markisz, E. Ramirez de Arellano, and E. Kazam. 1992. Prostate visualization studies in males homozygous and heterozygous for 5α-reductase deficiency. J. Clin. Endocrinol. Metab. 75:1022-1026.
5. Wilson, J.D., J.E. Griffin, and D.W. Russell. 1993. Steroid 5 alpha-reductase 2 deficiency. Endocr. Rev. 14:577-593.
6. Rittmaster, R.S., K.E. Magor, A.P. Manning, R.W. Norman, and C.B. Lazier. 1991. Differential effect of 5α-reductase inhibition and castration on androgen-regulated gene expression in rat prostate. Mol. Endocrinol. 5:1023-1029.
7. Shao T.C., A. Kong, P. Marafelia, and G.R. Cunningham. 1993. Effects of finasteride on the rat ventral prostate. J. Androl. 14:79-86.
8. Zhou, Z.X., M.V. Lane, J.A. Kemppainen, F.S. French, and E.M. Wilson. 1995. Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol. Endocrinol. 9:208-218.
9. Rittmasier, R.S., A.P. Manning, A.S. Wright, L.N. Thomas. S. Whitefield, R.W. Norman, C.B. Lazier, and G. Rowden. 1995. Evidence for atrophy and apoptosis in the ventral prostate of rats given the 5 alpha-reductase inhibitor finasteride. Endocrinology. 136:741-748.
10. Davis, L.G., M.D. Dibner, and J.F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier Science Publishing Co. Inc., New York. 130-133.
11. Davis, L.G., M.D. Dibner, and J.F. Battey. 1986. Basic Methods in Molecular Biology. Elsevier Science Publishing Co. Inc., New York. 147-149.
12. Sanford, W. 1985. Applied Linear Regression, Second edition. John Wiley and Sons, Toronto, Canada. 179-185.
13. Furuya, Y., and J.T. Isaacs. 1993. Differential gene regulation during programmed cell death (apoptosis) versus proliferation of prostatic glandular cells induced by androgen manipulation. Endocrinology. 133:2660-2666.
14. Leger, J.G., M.L. Monpetit, and M. Tenniswood. 1987. Characterization and cloning of androgen repressed mRNAs from rat ventral prostate. Biochem. Biophys. Res. Commun. 147:196-203.
15. Buttyan, R., C. Olsson, J. Pintar, C. Chang, M. Bandyk, P.-Y. Ng, and I.S. Sawczuk. 1989. Induction of the TRPM-2 gene in cells undergoing programmed death. Mol. Cell. Biol. 9:3473-3481.
16. Russo, P., J.A. Warner, R. Huryk, G. Perez, and W.D.W. Heston. 1994. TRPM-2 gene expression in normal rat ventral prostate following castration and exposure to diethylstilbestrol, flutamide, MK-906, (finasteride), and coumarin. Prostate. 24:237-243.
17. Briehl, M.M., and R.L. Miesfeld. 1991. Isolation and characterization of transcripts induced by androgen withdrawal and apoptotic cell death in the rat ventral prostate. Mol. Endocrinol. 5:1381-1388.
18. Anderson, K.M., and S. Liao. 1968. Selective retention of dihydrotestosterone by prostatic nuclei. Nature (Lond.). 219:277-279.
19. Jung-Testas, I., M.-T. Groyer, J. Bruner-Lorand, O. Hechter, E-E. Baulieu, and P. Robel. 1981. Androgen and estrogen receptors in rat ventral prostate epithelium and stroma. Endocrinology. 109:1287-1289.
20. Kuiper, G., E. Enmark, M. Pelto-Huikko, S. Nilsson, and J-A. Gustafsson. 1996. Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc. Natl. Acad. Sci. USA. 93:5925-5930.
21. Brolin, J., L. Skoog, and P. Ekman. 1992. Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue. Prostate. 20:281-295.
22. Schulze, H., and S. Claus. 1990. Histological localization of estrogen receptors in normal and diseased human prostates by immunocytochemistry. Prostate. 16:331-343.
23. Matzkin, H., and M.S. Soloway. 1992. Immunohistochemical evidence of the existence and localization of aromatase in human prostatic tissues. Prostate. 21:309-314.
24. Brodie, A.M., C. Son, D.A. King, K.M. Meyer, and S.E. Inkster. 1989. Lack of evidence for aromatase in human prostatic tissues: effects of 4-hydroxy-androstenedione and other inhibitors on androgen metabolism. Cancer Res. 49: 6551-6555.
25. Oesterling, J., P. Juiewicz, J. Walters, J. Strandenburg, R. Steele, L. Ewing, and D. Coffey. 1988. Aromatase inhibition in the dog. II. Effect on growth, function, and pathology of the prostate. J. Urol. 139:832-839.
26. Schweikert, H.U., U.W. Tunn, U.F. Habenicht, J. Arnold, T. Senge, H. Schulze, F.H. Schroder, J.H. Blom, O. Ennemoser, W. Horniger et al. 1993. Effects of estrogen deprivation on human benign prostatic hyperplasia. J. Steroid Biochem. Mol. Biol. 44:573-576.
27. Kyprianou, N., and J.T. Isaacs. 1987. Biological significance of measurable androgen levels in the rat ventral prostate following castration. Prostate. 10:313-324.
28. Kyprianou, N., and J.T. Isaacs. 1987. Quantal relationship between prostatic dihydrotestosterone and prostatic cell content: critical threshold concept. Prostate. 11:41-50.