Aspirin and clopidogrel alter core temperature and skin blood flow during heat stress

Medicine and Science in Sports and Exercise

Volumn 45, Issue 4, 2013, Pages 674-682

  Bruning, Rebecca S ^a   Dahmus, Jessica D ^a   Kenney, W Larry ^a   Alexander, Lacy M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Acetylsalicylic Acid; Esophageal Temperature; Laser Doppler Flowmetry; Plavix

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DRUG DERIVATIVE; TICLOPIDINE;

AGED; ARTICLE; BLOOD FLOW; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EQUIPMENT; EXERCISE TEST; FEMALE; HEAT INJURY; HUMAN; LASER DOPPLER FLOWMETRY; MALE; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN; THERMOGRAPHY; THERMOREGULATION; UNITED STATES; VASCULARIZATION;

AGED; ASPIRIN; BODY TEMPERATURE REGULATION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE TEST; FEMALE; HEAT STRESS DISORDERS; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MIDDLE AGED; PENNSYLVANIA; PLATELET AGGREGATION INHIBITORS; REGIONAL BLOOD FLOW; SKIN; THERMOGRAPHY; TICLOPIDINE;

EID: 84878827171     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31827981dc     Document Type: Article

References (41)

1. About Plavix (R) (Clopidogrel Bisulfate) [Internet]. Bridgewater (NJ): Bristol-Myers Squibb/Sanofi Pharmaceutical Parnership; [cited 2012 Aug 28]. Available from: http://www.plavix.com/clopidogrel.aspx.
2. Aoki K, Stephens DP, Johnson JM. Diurnal variation in cutaneous vasodilator and vasoconstrictor systems during heat stress. Am J Physiol Regul Integr Comp Physiol. 2001;281(2):R591-5.
3. Bass DE, Jacobson ED. Effects of salicylate on acclimatization to work in the heat. J Appl Physiol. 1965;20:70-2.
4. Borg G. Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med. 1970;2(2):92-8.
5. Bradford CD, Cotter JD, Thorburn MS, Walker RJ, Gerrard DF. Exercise can be pyrogenic in humans. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R143-9.
6. Brooks-Asplund EM, Cannon JG, KenneyWL. Influence of hormone replacement therapy and aspirin on temperature regulation in postmenopausal women. Am J Physiol Regul Integr Comp Physiol. 2000;279(3):R839-48.
7. Cannon CP, Rhee KE, Califf RM, et al. Current use of aspirin and antithrombotic agents in the United States among outpatients with atherothrombotic disease (from the REduction of Atherothrombosis for Continued Health [REACH] Registry). Am J Cardiol. 2010; 105(4):445-52.
8. Charkoudian N, Johnson JM. Modification of active cutaneous vasodilation by oral contraceptive hormones. J Appl Physiol. 1997; 83(6):2012-8.
9. Charkoudian N, Johnson JM. Altered reflex control of cutaneous circulation by female sex steroids is independent of prostaglandins. Am J Physiol. 1999;276(5 Pt 2):H1634-40.
10. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974;37(2):247-8.
11. Downey JA, Darling RC. Effect of salicylates on elevation of body temperature during exercise. J Appl Physiol. 1962;17:323-5.
12. Ellis KJ, Stouffer GA, McLeod HL, Lee CR. Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations. Pharmacogenomics J. 2009;10(11): 1799-817.
13. Goldsmith R, Fox RH, Hampton IF. Effects of drugs on heat acclimatization by controlled hyperthermia. J Appl Physiol. 1967; 22(2):301-4.
14. Haag MD, Bos MJ, Hofman A, Koudstaal PJ, Breteler MM, Stricker BH. Cyclooxygenase selectivity of nonsteroidal anti-drugs and risk of stroke. Arch Intern Med. 2008;168(11):1219-24.
15. Herber JM, Frehel D, Vallee E, et al. Clopidorel, a novel antiplatelet and antithrombotic agent. Cardiovasc Drug Rev. 1993; 11(2):180-98.
16. Holowatz LA, Houghton BL, Wong BJ, et al. Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin. Am J Physiol Heart Circ Physiol. 2003;284(5):H1662-7.
17. Holowatz LA, Jennings JD, Lang JA, Kenney WL. Ketorolac alters blood flow during normothermia but not during hyperthermia in middle-aged human skin. J Appl Physiol. 2009;107(4):1121-7.
18. Holowatz LA, Jennings JD, Lang JA, Kenney WL. Systemic lowdose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol. 2010; 108(6):1575-81.
19. Holowatz LA, Kenney WL. Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol. 2009;106(2):500-5.
20. Jacobson ED, Bass DE. Effects of sodium salicylate on physiological responses to work in heat. J Appl Physiol. 1964;19:33-6.
21. Kellogg DL Jr, Crandall CG, Liu Y, Charkoudian N, Johnson JM. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol. 1998;85(3):824-9.
22. Kellogg DL Jr, Pergola PE, Piest KL, et al. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res. 1995;77(6):1222-8.
23. Kenney WL, Morgan AL, Farquhar WB, Brooks EM, Pierzga JM, Derr JA. Decreased active vasodilator sensitivity in aged skin. Am J Phys. 1997;272(4 Pt 2):H1609-14.
24. Ma TK, Lam YY, Tan VP, Kiernan TJ, Yan BP. Impact of genetic and acquired alteration in cytochrome P450 system on pharmacologic and clinical response to clopidogrel. Pharmacol Ther. 2010; 125(2):249-59.
25. Martin HL, Loomis JL, Kenney WL. Maximal skin vascular conductance in subjects aged 5-85 yr. J Appl Physiol. 1995;79(1):297-301.
26. Mason KD, Carpinelli MR, Fletcher JI, et al. Programmed anuclear cell death delimits platelet life span. Cell. 2007;128(6):1173-86.
27. McCord GR, Cracowski JL, Minson CT. Prostanoids contribute to cutaneous active vasodilation in humans. Am J Physiol Regul Integr Comp Physiol. 2006;291(3):R596-R602.
28. Momary KM, Dorsch MP. Factors associated with clopidogrel nonresponsiveness. Future Cardiol. 2010;6(2):195-210.
29. Nadel ER, Horvath SM, Dawson CA, Tucker A. Sensitivity to central and peripheral thermal stimulation in man. J Appl Physiol. 1970;29(5):603-9.
30. Patrono C, Baigent C, Hirsh J, Roth G. Antiplatelet drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):199S-233S.
31. Patrono C, Ciabattoni G, Patrignani P, et al. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation. 1985; 72(6):1177-84.
32. Patrono C, Coller B, Dalen JE, et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest. 2001;119(Suppl 1):39S-63S.
33. Quinn MJ, Fitzgerald DJ. Ticlopidine and clopidogrel. Circulation. 1999;100(15):1667-72.
34. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18-e209.
35. Rousseau P, Tartas M, Fromy B, et al. Platelet inhibition by low-dose aspirin but not by clopidogrel reduces the axon-reflex current-induced vasodilation in humans. Am J Physiol Regul Integr Comp Physiol. 2008;294(5):R1420-6.
36. Shastry S, Dietz NM, Halliwill JR, Reed AS, Joyner MJ. Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans. J Appl Physiol. 1998; 85(3):830-4.
37. Stolwijk JA, Hardy JD. Partitional calorimetric studies of responses of man to thermal transients. J Appl Physiol. 1966; 21(3):967-77.
38. Thompson CS, Kenney WL. Altered neurotransmitter control of reflex vasoconstriction in aged human skin. J Appl Physiol. 2004; 558(Pt 2):697-704.
39. Uchiyama S. Clopidogrel resistance: identifying and overcoming a barrier to effective antiplatelet treatment. Cardiovasc Ther. 2011; 29(6):e100-11.
40. Whitney RJ. The measurement of volume changes in human limbs. J Physiol. 1953;121(1):1-27.
41. Young AJ, Sawka MN, Epstein Y, Decristofano B, Pandolf KB. Cooling different body surfaces during upper and lower body exercise. J Appl Physiol. 1987;63(3):1218-23.