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Volumn 56, Issue 2, 2013, Pages 412-422

CAMP response element binding protein H mediates fenofibrate-induced suppression of hepatic lipogenesis

Author keywords

CREBH; Fenofibrate; Hepatic steatosis; Lipogenesis; SREBP 1c

Indexed keywords

FENOFIBRATE; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84878806915     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2771-2     Document Type: Article
Times cited : (20)

References (46)
  • 1
    • 0033329864 scopus 로고    scopus 로고
    • Liver pathology and the metabolic syndrome X in severe obesity
    • 10323371 10.1210/jc.84.5.1513 1:CAS:528:DyaK1MXjtFClur0%3D
    • Marceau P, Biron S, Hould FS et al (1999) Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab 84:1513-1517
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1513-1517
    • Marceau, P.1    Biron, S.2    Hould, F.S.3
  • 2
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • 10569299 10.1016/S0002-9343(99)00271-5 1:CAS:528:DyaK1MXnvFymurc%3D
    • Marchesini G, Brizi M, Morselli-Labate AM et al (1999) Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 107:450-455
    • (1999) Am J Med , vol.107 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 3
    • 0036864411 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis
    • 12440980 10.1042/BST0301091 1:CAS:528:DC%2BD38XovF2itrs%3D
    • Horton JD (2002) Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans 30:1091-1095
    • (2002) Biochem Soc Trans , vol.30 , pp. 1091-1095
    • Horton, J.D.1
  • 4
    • 0034905540 scopus 로고    scopus 로고
    • Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance
    • 11481396 1:CAS:528:DC%2BD3MXlvFKksrY%3D
    • Zammit VA, Waterman IJ, Topping D, McKay G (2001) Insulin stimulation of hepatic triacylglycerol secretion and the etiology of insulin resistance. J Nutr 131:2074-2077
    • (2001) J Nutr , vol.131 , pp. 2074-2077
    • Zammit, V.A.1    Waterman, I.J.2    Topping, D.3    McKay, G.4
  • 5
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • 10514488 10.1074/jbc.274.42.30028 1:CAS:528:DyaK1MXmvVajt70%3D
    • Shimomura I, Bashmakov Y, Horton JD (1999) Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274:30028-30032
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 6
    • 12744271884 scopus 로고    scopus 로고
    • Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements
    • 15330762 10.1042/BJ20040162 1:CAS:528:DC%2BD2cXhtVOhtL7P
    • Cagen LM, Deng X, Wilcox HG, Park EA, Raghow R, Elam MB (2005) Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem J 385:207-216
    • (2005) Biochem J , vol.385 , pp. 207-216
    • Cagen, L.M.1    Deng, X.2    Wilcox, H.G.3    Park, E.A.4    Raghow, R.5    Elam, M.B.6
  • 7
    • 0037088683 scopus 로고    scopus 로고
    • Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    • 11782483 10.1074/jbc.M111421200 1:CAS:528:DC%2BD38Xitl2ktL8%3D
    • Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS (2002) Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem 277:9520-9528
    • (2002) J Biol Chem , vol.277 , pp. 9520-9528
    • Liang, G.1    Yang, J.2    Horton, J.D.3    Hammer, R.E.4    Goldstein, J.L.5    Brown, M.S.6
  • 8
    • 33744821064 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
    • 16381800 10.1152/ajpcell.00374.2005 1:CAS:528:DC%2BD28XlvVejt7s%3D
    • Lu M, Shyy JY (2006) Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am J Physiol Cell Physiol 290:C1477-C1486
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Lu, M.1    Shyy, J.Y.2
  • 9
    • 34249721531 scopus 로고    scopus 로고
    • Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver
    • 17296605 10.1074/jbc.M611911200 1:CAS:528:DC%2BD2sXktFemur0%3D
    • Yamamoto T, Shimano H, Inoue N et al (2007) Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver. J Biol Chem 282:11687-11695
    • (2007) J Biol Chem , vol.282 , pp. 11687-11695
    • Yamamoto, T.1    Shimano, H.2    Inoue, N.3
  • 10
    • 0028085233 scopus 로고
    • Regulation of lipogenic enzyme gene expression by nutrients and hormones
    • 7905448 1:CAS:528:DyaK2cXhs1ahu78%3D
    • Girard J, Perdereau D, Foufelle F, Prip-Buus C, Ferre P (1994) Regulation of lipogenic enzyme gene expression by nutrients and hormones. FASEB J 8:36-42
    • (1994) FASEB J , vol.8 , pp. 36-42
    • Girard, J.1    Perdereau, D.2    Foufelle, F.3    Prip-Buus, C.4    Ferre, P.5
  • 11
    • 39149145837 scopus 로고    scopus 로고
    • Fenofibrate reduces lipoprotein associated phospholipase A2 mass and oxidative lipids in hypertriglyceridemic subjects with the metabolic syndrome
    • Rosenson RS (2008) Fenofibrate reduces lipoprotein associated phospholipase A2 mass and oxidative lipids in hypertriglyceridemic subjects with the metabolic syndrome. Am Heart J 155:499.9-16
    • (2008) Am Heart J , vol.155 , Issue.499 , pp. 9-16
    • Rosenson, R.S.1
  • 13
    • 77955483485 scopus 로고    scopus 로고
    • Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden. CETP mice
    • 20501652 10.1074/jbc.M110.123992 1:CAS:528:DC%2BC3cXpslKjsb4%3D
    • Bijland S, Pieterman EJ, Maas AC et al (2010) Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice. J Biol Chem 285:25168-25175
    • (2010) J Biol Chem , vol.285 , pp. 25168-25175
    • Bijland, S.1    Pieterman, E.J.2    Maas, A.C.3
  • 14
    • 0018726338 scopus 로고
    • Influence of procetofen on lipid metabolism in normocholesteremic rats
    • 515111 10.1016/S0031-6989(79)80053-3 1:CAS:528:DyaL3cXjsVWnsg%3D%3D
    • Kritchevsky D, Tepper SA, Story JA (1979) Influence of procetofen on lipid metabolism in normocholesteremic rats. Pharmacol Res Commun 11:635-641
    • (1979) Pharmacol Res Commun , vol.11 , pp. 635-641
    • Kritchevsky, D.1    Tepper, S.A.2    Story, J.A.3
  • 15
    • 0030658022 scopus 로고    scopus 로고
    • Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
    • 9353271 10.1074/jbc.272.45.28210 1:CAS:528:DyaK2sXntlCrsbY%3D
    • Martin G, Schoonjans K, Lefebvre AM, Staels B, Auwerx J (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem 272:28210-28217
    • (1997) J Biol Chem , vol.272 , pp. 28210-28217
    • Martin, G.1    Schoonjans, K.2    Lefebvre, A.M.3    Staels, B.4    Auwerx, J.5
  • 16
    • 0029144018 scopus 로고
    • Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter
    • 7642600 10.1074/jbc.270.33.19269 1:CAS:528:DyaK2MXnsFyhu7w%3D
    • Schoonjans K, Watanabe M, Suzuki H et al (1995) Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 270:19269-19276
    • (1995) J Biol Chem , vol.270 , pp. 19269-19276
    • Schoonjans, K.1    Watanabe, M.2    Suzuki, H.3
  • 17
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • 8725145 1:CAS:528:DyaK28Xjtl2nu74%3D
    • Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907-925
    • (1996) J Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 18
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation
    • 8695669 10.1016/0005-2760(96)00066-5 1:STN:280:DyaK28zhtlygsA%3D%3D
    • Schoonjans K, Staels B, Auwerx J (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302:93-109
    • (1996) Biochim Biophys Acta , vol.1302 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 19
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • 2129546 10.1038/347645a0 1:CAS:528:DyaK3MXhsl2gs7g%3D
    • Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650
    • (1990) Nature , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 20
    • 0026488464 scopus 로고
    • Perturbation of developmental gene expression in rat liver by fibric acid derivatives: Lipoprotein lipase and alpha-fetoprotein as models
    • 1280557 1:CAS:528:DyaK3sXjt1Oqug%3D%3D
    • Staels B, Auwerx J (1992) Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models. Development 115:1035-1043
    • (1992) Development , vol.115 , pp. 1035-1043
    • Staels, B.1    Auwerx, J.2
  • 21
    • 17844395201 scopus 로고    scopus 로고
    • The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
    • 15800215 10.1093/nar/gki332 1:CAS:528:DC%2BD2MXjtlensLk%3D
    • Chin KT, Zhou HJ, Wong CM et al (2005) The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Nucleic Acids Res 33:1859-1873
    • (2005) Nucleic Acids Res , vol.33 , pp. 1859-1873
    • Chin, K.T.1    Zhou, H.J.2    Wong, C.M.3
  • 22
    • 0035873671 scopus 로고    scopus 로고
    • CREB-H: A novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression
    • 11353085 10.1093/nar/29.10.2154 1:CAS:528:DC%2BD3MXktlanu70%3D
    • Omori Y, Imai J, Watanabe M et al (2001) CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression. Nucleic Acids Res 29:2154-2162
    • (2001) Nucleic Acids Res , vol.29 , pp. 2154-2162
    • Omori, Y.1    Imai, J.2    Watanabe, M.3
  • 23
    • 32044453080 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
    • 16469704 10.1016/j.cell.2005.11.040 1:CAS:528:DC%2BD28Xhslaqs7Y%3D
    • Zhang K, Shen X, Wu J et al (2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124:587-599
    • (2006) Cell , vol.124 , pp. 587-599
    • Zhang, K.1    Shen, X.2    Wu, J.3
  • 24
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
    • 10535992 10.1073/pnas.96.22.12737 1:CAS:528:DyaK1MXnt1yqsb0%3D
    • Foretz M, Guichard C, Ferre P, Foufelle F (1999) Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci U S A 96:12737-12742
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 25
    • 79960110157 scopus 로고    scopus 로고
    • The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
    • 21666694 10.1038/nm.2347 1:CAS:528:DC%2BC3MXnsVajtr8%3D
    • Lee JH, Giannikopoulos P, Duncan SA et al (2011) The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 17:812-815
    • (2011) Nat Med , vol.17 , pp. 812-815
    • Lee, J.H.1    Giannikopoulos, P.2    Duncan, S.A.3
  • 26
    • 84862828272 scopus 로고    scopus 로고
    • Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
    • 22095841 10.1002/hep.24783 1:CAS:528:DC%2BC38Xks1yjsrw%3D
    • Zhang C, Wang G, Zheng Z et al (2012) Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 55:1070-1082
    • (2012) Hepatology , vol.55 , pp. 1070-1082
    • Zhang, C.1    Wang, G.2    Zheng, Z.3
  • 27
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • 9600904 10.1073/pnas.95.11.5987 1:CAS:528:DyaK1cXjtlKhtbY%3D
    • Horton JD, Bashmakov Y, Shimomura I, Shimano H (1998) Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci U S A 95:5987-5992
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 28
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • 15266058 10.1073/pnas.0404297101 1:CAS:528:DC%2BD2cXmvVKgt74%3D
    • Chen G, Liang G, Ou J, Goldstein JL, Brown MS (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A 101:11245-11250
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 29
    • 56149098763 scopus 로고    scopus 로고
    • Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways
    • 18972440 10.1002/hep.22496 1:CAS:528:DC%2BD1cXhsVKmtrfI
    • Park KG, Min AK, Koh EH et al (2008) Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology 48:1477-1486
    • (2008) Hepatology , vol.48 , pp. 1477-1486
    • Park, K.G.1    Min, A.K.2    Koh, E.H.3
  • 30
    • 77950285163 scopus 로고    scopus 로고
    • Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH
    • 20374965 10.1016/j.cmet.2010.02.016 1:CAS:528:DC%2BC3cXlsVajur0%3D
    • Lee MW, Chanda D, Yang J et al (2010) Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab 11:331-339
    • (2010) Cell Metab , vol.11 , pp. 331-339
    • Lee, M.W.1    Chanda, D.2    Yang, J.3
  • 31
    • 71749090862 scopus 로고    scopus 로고
    • Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice
    • 19801551 10.1074/jbc.M109.051052 1:CAS:528:DC%2BD1MXhsVymu7nI
    • Oosterveer MH, Grefhorst A, van Dijk TH et al (2009) Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice. J Biol Chem 284:34036-34044
    • (2009) J Biol Chem , vol.284 , pp. 34036-34044
    • Oosterveer, M.H.1    Grefhorst, A.2    Van Dijk, T.H.3
  • 32
    • 77951237924 scopus 로고    scopus 로고
    • Characterization of the human insulin-induced gene 2 (INSIG2) promoter: The role of Ets-binding motifs
    • 20145255 10.1074/jbc.M109.067447 1:CAS:528:DC%2BC3cXksVGlsLo%3D
    • Fernandez-Alvarez A, Soledad Alvarez M, Cucarella C, Casado M (2010) Characterization of the human insulin-induced gene 2 (INSIG2) promoter: the role of Ets-binding motifs. J Biol Chem 285:11765-11774
    • (2010) J Biol Chem , vol.285 , pp. 11765-11774
    • Fernandez-Alvarez, A.1    Soledad Alvarez, M.2    Cucarella, C.3    Casado, M.4
  • 33
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • 19363290 10.1172/JCI37007 1:CAS:528:DC%2BD1MXlsFyrsbg%3D
    • Kammoun HL, Chabanon H, Hainault I et al (2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119:1201-1215
    • (2009) J Clin Invest , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3
  • 34
    • 70450283986 scopus 로고    scopus 로고
    • Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex
    • 19759400 10.1074/jbc.M109.050914 1:CAS:528:DC%2BD1MXhtlyjsLjI
    • Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB (2009) Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex. J Biol Chem 284:31726-31734
    • (2009) J Biol Chem , vol.284 , pp. 31726-31734
    • Yellaturu, C.R.1    Deng, X.2    Park, E.A.3    Raghow, R.4    Elam, M.B.5
  • 35
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • 15254578 1:CAS:528:DC%2BD2cXlvFWms7c%3D
    • Browning JD, Horton JD (2004) Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114:147-152
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 36
    • 74149092293 scopus 로고    scopus 로고
    • Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis
    • 20005944 10.1016/j.freeradbiomed.2009.12.006 1:CAS:528: DC%2BC3cXhtVaksL0%3D
    • Kim YW, Kim YM, Yang YM et al (2010) Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis. Free Radic Biol Med 48:567-578
    • (2010) Free Radic Biol Med , vol.48 , pp. 567-578
    • Kim, Y.W.1    Kim, Y.M.2    Yang, Y.M.3
  • 37
    • 34547102250 scopus 로고    scopus 로고
    • Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1)
    • 17449871 10.1074/jbc.M702228200 1:CAS:528:DC%2BD2sXmt1ektLo%3D
    • Deng X, Yellaturu C, Cagen L et al (2007) Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1). J Biol Chem 282:17517-17529
    • (2007) J Biol Chem , vol.282 , pp. 17517-17529
    • Deng, X.1    Yellaturu, C.2    Cagen, L.3
  • 38
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • 9356024 10.2337/diabetes.46.11.1768 1:CAS:528:DyaK2sXntVKisLs%3D
    • Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW (1997) Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46:1768-1774
    • (1997) Diabetes , vol.46 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 39
    • 62649093597 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells
    • 19125418 10.1002/jcb.22024 1:CAS:528:DC%2BD1MXhvVyhurk%3D
    • Yang J, Craddock L, Hong S, Liu ZM (2009) AMP-activated protein kinase suppresses LXR-dependent sterol regulatory element-binding protein-1c transcription in rat hepatoma McA-RH7777 cells. J Cell Biochem 106:414-426
    • (2009) J Cell Biochem , vol.106 , pp. 414-426
    • Yang, J.1    Craddock, L.2    Hong, S.3    Liu, Z.M.4
  • 40
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • 16511593 10.1172/JCI27883 1:CAS:528:DC%2BD28XitlGkt7o%3D
    • Zelcer N, Tontonoz P (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116:607-614
    • (2006) J Clin Invest , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 41
    • 28044452217 scopus 로고    scopus 로고
    • Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • 16310551 10.1016/S0140-6736(05)67667-2 1:STN:280:DC%2BD2MnjtVCnsg%3D%3D
    • Keech A, Simes RJ, Barter P et al (2005) Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366:1849-1861
    • (2005) Lancet , vol.366 , pp. 1849-1861
    • Keech, A.1    Simes, R.J.2    Barter, P.3
  • 42
    • 35048892406 scopus 로고    scopus 로고
    • Normalization of metabolic syndrome using fenofibrate, metformin or their combination
    • 10.1111/j.1463-1326.2006.00668.x 1:CAS:528:DC%2BD2sXhtlOlsLjN
    • Nieuwdorp M, Stroes ES, Kastelein JJ (2007) Normalization of metabolic syndrome using fenofibrate, metformin or their combination. Diabetes Obes Metabol 9:869-878
    • (2007) Diabetes Obes Metabol , vol.9 , pp. 869-878
    • Nieuwdorp, M.1    Stroes, E.S.2    Kastelein, J.J.3
  • 43
    • 35548979848 scopus 로고    scopus 로고
    • The role of fenofibrate in clinical practice
    • Zambon A, Cusi K (2007) The role of fenofibrate in clinical practice. Diabetes Vasc Dis Res 4(Suppl 3):S15-S20
    • (2007) Diabetes Vasc Dis Res , vol.4 , Issue.SUPPL. 3
    • Zambon, A.1    Cusi, K.2
  • 44
    • 73449099559 scopus 로고    scopus 로고
    • The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha
    • 20006574 10.1016/j.bbrc.2009.12.046 1:CAS:528:DC%2BC3cXktVWlsw%3D%3D
    • Danno H, Ishii KA, Nakagawa Y et al (2010) The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. Biochem Biophys Res Commun 391:1222-1227
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1222-1227
    • Danno, H.1    Ishii, K.A.2    Nakagawa, Y.3
  • 45
    • 59349083174 scopus 로고    scopus 로고
    • The role of LXR alpha in goose primary hepatocyte lipogenesis
    • 18975056 10.1007/s11010-008-9937-8 1:CAS:528:DC%2BD1MXhtVWhsbw%3D
    • Han C, Wang J, Li L, Wang L, Zhang Z (2009) The role of LXR alpha in goose primary hepatocyte lipogenesis. Mol Cell Biochem 322:37-42
    • (2009) Mol Cell Biochem , vol.322 , pp. 37-42
    • Han, C.1    Wang, J.2    Li, L.3    Wang, L.4    Zhang, Z.5
  • 46
    • 0142103471 scopus 로고    scopus 로고
    • The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression
    • 12917410 10.1074/jbc.M307973200 1:CAS:528:DC%2BD3sXotFWgsL4%3D
    • Pawar A, Botolin D, Mangelsdorf DJ, Jump DB (2003) The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. J Biol Chem 278:40736-40743
    • (2003) J Biol Chem , vol.278 , pp. 40736-40743
    • Pawar, A.1    Botolin, D.2    Mangelsdorf, D.J.3    Jump, D.B.4


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