Computer-aided diagnosis and localization of lateralized temporal lobe epilepsy using interictal FDG-PET

Frontiers in Neurology

Volumn 4 APR, Issue , 2013, Pages

  Kerr, Wesley T ^a,b   Nguyen, Stefan T ^a   Cho, Andrew Y ^b   Lau, Edward P ^b   Silverman, Daniel H ^a   Douglas, Pamela K ^b   Reddy, Navya M ^a   Anderson, Ariana ^b   Bramen, Jennifer ^b   Salamon, Noriko ^a   Stern, John M ^a   Cohen, Mark S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Computer aided diagnosis; Epilepsy; Fluoro deoxyglucose positron emission tomography; Machine learning; Mutual information; PET; Temporal lobe epilepsy

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADOLESCENT; ADULT; AGED; ARTICLE; COMPUTER ASSISTED DIAGNOSIS; COMPUTER ASSISTED RADIOGRAPHY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DISEASE DURATION; FRONTAL CORTEX; HUMAN; IMAGE ANALYSIS; INTERICTAL POSITRON EMISSION TOMOGRAPHY; LATERAL TEMPORAL LOBE EPILEPSY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; VISUAL INFORMATION;

EID: 84878798130     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2013.00031     Document Type: Article

References (95)

1. Arnold, S., Schlaug, G., Niemann, H., Ebner, A., Luders, H., Witte, O. W., et al. (1996). Topography of interictal glucose hypometabolism in unilateral mesiotemporal epilepsy. Neurology 46, 1422-1430.
2. Barrick, T. R., Mackay, C. E., Prima, S., Maes, F., Vandermeulen, D., Crow, T. J., et al. (2005). Automatic analysis of cerebral asymmetry: an exploratory study of the relationship between brain torque and planum temporale asymmetry. Neuroimage 24, 678-691.
3. Barrington, S. F., Koutroumanidis, M., Agathonikou, A., Marsden, P. K., Binnie, C. D., Polkey, C. E., et al. (1998). Clinical value of "ictal". Epilepsia 39, 753-766.
4. Benbadis, S. R., Tatum, W. O. T., Murtagh, F. R., and Vale, F. L. (2000). MRI evidence of mesial temporal sclerosis in patients with psychogenic nonepileptic seizures. Neurology 55, 1061-1062.
5. Benedek, K., Juhasz, C., Muzik, O., Chugani, D. C., and Chugani, H. T. (2004). Metabolic changes of subcortical structures in intractable focal epilepsy. Epilepsia 45, 1100-1105.
6. Bernasconi, A., Bernasconi, N., Bernhardt, B. C., and Schrader, D. (2011). Advances in MRI for 'cryptogenic' epilepsies. Nat. Rev. Neurol. 7, 99-108.
7. Blum, D. E., Ehsan, T., Dungan, D., Karis, J. P., and Fisher, R. S. (1998). Bilateral temporal hypometabolism in epilepsy. Epilepsia 39, 651-659.
8. Bouckaert, R. R., Frank, E., Hall, M. A., Holmes, G., Pfahringer, B., Ruetemann, P., et al. (2010). Weka-experiences with a java open-source project. J. Mach. Learn. Res. 11, 2533-2541.
9. Bouilleret, V., Dupont, S., Spelle, L., Baulac, M., Samson, Y., and Semah, F. (2002). Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study. Ann. Neurol. 51, 202-208.
10. Brodbeck, V., Spinelli, L., Lascano, A. M., Pollo, C., Schaller, K., Vargas, M. I., et al. (2010). Electrical source imaging for presurgical focus localization in epilepsy patients with normal MRI. Epilepsia 51, 583-591.
11. Carne, R. P., O'Brien, T. J., Kilpatrick, C. J., MacGregor, L. R., Hicks, R. J., Murphy, M. A., et al. (2004). MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain 127, 2276-2285.
12. Chandra, P. S., Salamon, N., Huang, J., Wu, J. Y., Koh, S., Vinters, H. V., et al. (2006). FDG-PET/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia 47, 1543-1549.
13. Chauvin, A., Worsley, K. J., Schyns, P. G., Arguin, M., and Gosselin, F. (2005). Accurate statistical tests for smooth classification images. J. Vis. 5, 659-667.
14. Chinchure, S., Kesavadas, C., and Thomas, B. (2010). Structural and functional neuroimaging in intractable epilepsy. Neurol. India 58, 361-370.
15. Cragar, D. E., Berry, D. T., Fakhoury, T. A., Cibula, J. E., and Schmitt, F. A. (2002). A review of diagnostic techniques in the differential diagnosis of epileptic and nonepileptic seizures. Neuropsychol. Rev. 12, 31-64.
16. Dabbs, K., Becker, T., Jones, J., Rutecki, P., Seidenberg, M., and Hermann, B. (2012). Brain structure and aging in chronic temporal lobe epilepsy. Epilepsia 53, 1033-1043.
17. Debets, R. M., Sadzot, B., Van Isselt, J. W., Brekelmans, G. J., Meiners, L. C., Van Huffelen, A. O., et al. (1997). Is 11C-flumazenil PET superior to 18FDG PET and 123I-iomazenil SPECT in presurgical evaluation of temporal lobe epilepsy? J. Neurol. Neurosurg. Psychiatr. 62, 141-150.
18. Delaney, R. C., Rosen, A. J., Mattson, R. H., and Novelly, R. A. (1980). Memory function in focal epilepsy: a comparison of non-surgical, unilateral temporal lobe and frontal lobe samples. Cortex 16, 103-117.
19. Ding, C., and Peng, H. C. (2005). Minimum redundancy feature selection from microarray gene expression data. J. Bioinform. Comput. Biol. 3, 185-205.
20. Dlugos, D. J., Jaggi, J., O'Connor, W. M., Ding, X. S., Reivich, M., O'Connor, M. J., et al. (1999). Hippocampal cell density and subcortical metabolism in temporal lobe epilepsy. Epilepsia 40, 408-413.
21. Drzezga, A., Arnold, S., Minoshima, S., Noachtar, S., Szecsi, J., Winkler, P., et al. (1999). 18F-FDG PET studies in patients with extratemporal and temporal epilepsy: evaluation of an observer-independent analysis. J. Nucl. Med. 40, 737-746.
22. Duncan, J. (2009). The current status of neuroimaging for epilepsy. Curr. Opin. Neurol. 22, 179-184.
23. Engel, J. Jr., McDermott, M. P., Wiebe, S., Langfitt, J. T., Stern, J. M., Dewar, S., et al. (2012). Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA 307, 922-930.
24. Farid, N., Girard, H. M., Kemmotsu, N., Smith, M. E., Magda, S. W., Lim, W. Y., et al. (2012). Temporal lobe epilepsy: quantitative MR volumetry in detection of hippocampal atrophy. Radiology 264, 542-550.
25. Focke, N. K., Yogarajah, M., Symms, M. R., Gruber, O., Paulus, W., and Duncan, J. S. (2012). Automated MR image classification in temporal lobe epilepsy. Neuroimage 59, 356-362.
26. Gaillard, W. D., Bhatia, S., Bookheimer, S. Y., Fazilat, S., Sato, S., and Theodore, W. H. (1995). FDG-PET and volumetric MRI in the evaluation of patients with partial epilepsy. Neurology 45, 123-126.
27. Gilbert, D. L., Sethuraman, G., Kotagal, U., and Buncher, R. (2003). Meta-analysis of EEG test performance shows wide variation among studies. Neurology 60, 564-570.
28. Haneef, Z., Lenartowicz, A., Yeh, H. J., Engel, J. Jr., and Stern, J. M. (2012). Effect of lateralized temporal lobe epilepsy on the default mode network. Epilepsy Behav. 25, 350-357.
29. Henry, T. R., Chupin, M., Lehericy, S., Strupp, J. P., Sikora, M. A., Sha, Z. Y., et al. (2011). Hippocampal sclerosis in temporal lobe epilepsy: findings at 7 T. Radiology 261, 199-209.
30. Henry, T. R., Mazziotta, J. C., and Engel, J. Jr. (1993). Interictal metabolic anatomy of mesial temporal lobe epilepsy. Arch. Neurol. 50, 582-589.
31. Henry, T. R., Mazziotta, J. C., Engel, J. Jr., Christenson, P. D., Zhang, J. X., Phelps, M. E., et al. (1990). Quantifying interictal metabolic activity in human temporal lobe epilepsy. J. Cereb. Blood Flow Metab. 10, 748-757.
32. Henry, T. R., and Roman, D. D. (2011). Presurgical epilepsy localization with interictal cerebral dysfunction. Epilepsy Behav. 20, 194-208.
33. Henry, T. R., Ross, D. A., Schuh, L. A., and Drury, I. (1999). Indications and outcome of ictal recording with intracerebral and subdural electrodes in refractory complex partial seizures. J. Clin. Neurophysiol. 16, 426-438.
34. Iturria-Medina, Y., Perez Fernandez, A., Morris, D. M., Canales-Rodriguez, E. J., Haroon, H. A., Garcia Penton, L., et al. (2011). Brain hemispheric structural efficiency and interconnectivity rightward asymmetry in human and nonhuman primates. Cereb. Cortex 21, 56-67.
35. Juhasz, C., Nagy, F., Watson, C., Da Silva, E. A., Muzik, O., Chugani, D. C., et al. (1999). Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 53, 2037-2045.
36. Jung da, E., and Lee, J. S. (2010). Multimodal neuroimaging in presurgical evaluation of childhood epilepsy. Korean J. Pediatr. 53, 779-785.
37. Jupp, B., Williams, J., Binns, D., Hicks, R. J., Cardamone, L., Jones, N., et al. (2012). Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE. Epilepsia 53, 1233-1244.
38. Keihaninejad, S., Heckemann, R. A., Gousias, I. S., Hajnal, J. V., Duncan, J. S., Aljabar, P., et al. (2012). Classification and lateralization of temporal lobe epilepsies with and without hippocampal atrophy based on whole-brain automatic MRI segmentation. PLoS ONE 7:e33096. doi:10.1371/journal.pone.0033096
39. Kerr, W. T., Anderson, A., Lau, E. P., Cho, A. Y., Xia, H., Bramen, J., et al. (2012a). Automated diagnosis of epilepsy using EEG power spectrum. Epilepsia 53, e189-192.
40. Kerr, W. T., Anderson, A., Xia, H., Braun, E. S., Lau, E. P., Cho, A. Y., et al. (2012b). 2nd International Workshop Pattern Recognition in Neuroimaging. London: Conference Publishing Services.
41. Kerr, W. T., Lau, E. P., Owens, G. E., and Trefler, A. (2012c). The future of medical diagnostics: large digitized databases. Yale J. Biol. Med. 85, 363-377.
42. Kerr, W. T., and Lau, E. P. (2012). Poisson noise obscures hypometabolic lesions in PET. Yale J. Biol. Med. 85, 541-549.
43. Kim, H., Yi, S., Son, E. I., and Kim, J. (2003). Differential effects of left versus right mesial temporal lobe epilepsy on Wechsler intelligence factors. Neuropsychology 17, 556-565.
44. Kim, Y. H., Kang, H. C., Kim, D. S., Kim, S. H., Shim, K. W., Kim, H. D., et al. (2011). Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery. Epilepsia 52, 722-727.
45. Knowlton, R. C., Elgavish, R. A., Bartolucci, A., Ojha, B., Limdi, N., Blount, J., et al. (2008). Functional imaging: II. Prediction of epilepsy surgery outcome. Ann. Neurol. 64, 35-41.
46. Knowlton, R. C., Laxer, K. D., Ende, G., Hawkins, R. A., Wong, S. T., Matson, G. B., et al. (1997). Presurgical multimodality neuroimaging in electroencephalographic lateralized temporal lobe epilepsy. Ann. Neurol. 42, 829-837.
47. Kucyi, A., Moayedi, M., Weissman-Fogel, I., Hodaie, M., and Davis, K. D. (2012). Hemispheric asymmetry in white matter connectivity of the temporoparietal junction with the insula and prefrontal cortex. PLoS ONE 7:e35589. doi:10.1371/journal.pone.0035589
48. LaFrance, W. C. Jr., and Benbadis, S. R. (2011). Differentiating frontal lobe epilepsy from psychogenic nonepileptic seizures. Neurol. Clin. 29, 149-162.
49. LaFrance, W. C. Jr., and Devinsky, O. (2004). The treatment of nonepileptic seizures: historical perspectives and future directions. Epilepsia 45(Suppl. 2), 15-21.
50. Lee, E. M., Im, K. C., Kim, J. H., Lee, J. K., Hong, S. H., No, Y. J., et al. (2009). Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: an FDG-PET study. Epilepsy Res. 84, 187-193.
51. Lee, K. K., and Salamon, N. (2009). [18F] fluorodeoxyglucose-positron-emission tomography and MR imaging coregistration for presurgical evaluation of medically refractory epilepsy. AJNR Am. J. Neuroradiol. 30, 1811-1816.
52. Lerner, J. T., Salamon, N., Hauptman, J. S., Velasco, T. R., Hemb, M., Wu, J. Y., et al. (2009). Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia 50, 1310-1335.
53. Liao, W., Zhang, Z., Pan, Z., Mantini, D., Ding, J., Duan, X., et al. (2011). Default mode network abnormalities in mesial temporal lobe epilepsy: a study combining fMRI and DTI. Hum. Brain Mapp. 32, 883-895.
54. Liew, C. J., Lim, Y. M., Bonwetsch, R., Shamim, S., Sato, S., Reeves-Tyer, P., et al. (2009). 18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy. Epilepsia 50, 234-239.
55. Lin, T. W., De Aburto, M. A., Dahlbom, M., Huang, L. L., Marvi, M. M., Tang, M., et al. (2007). Predicting seizure-free status for temporal lobe epilepsy patients undergoing surgery: prognostic value of quantifying maximal metabolic asymmetry extending over a specified proportion of the temporal lobe. J. Nucl. Med. 48, 776-782.
56. Liu, R. S., Lemieux, L., Bell, G. S., Sisodiya, S. M., Bartlett, P. A., Shorvon, S. D., et al. (2002). The structural consequences of newly diagnosed seizures. Ann. Neurol. 52, 573-580.
57. Marchetti, R. L., Kurcgant, D., Gallucci Neto, J., Von Bismark, M. A., and Fiore, L. A. (2009). Evaluating patients with suspected nonepileptic psychogenic seizures. J. Neuropsychiatry Clin. Neurosci. 21, 292-298.
58. Marchetti, R. L., Kurcgant, D., Neto, J. G., Von Bismark, M. A., Marchetti, L. B., and Fiore, L. A. (2008). Psychiatric diagnoses of patients with psychogenic non-epileptic seizures. Seizure 17, 247-253.
59. Matheja, P., Kuwert, T., Ludemann, P., Weckesser, M., Kellinghaus, C., Schuierer, G., et al. (2001). Temporal hypometabolism at the onset of cryptogenic temporal lobe epilepsy. Eur. J. Nucl. Med. 28, 625-632.
60. McCormick, C., Quraan, M., Cohn, M., Valiante, T. A., and McAndrews, M. P. (2013). Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsy. Epilepsia. doi:10.1111/epi.12098. [Epub ahead of print].
61. Morgan, V. L., Rogers, B. P., Sonmezturk, H. H., Gore, J. C., and Abou-Khalil, B. (2011). Cross hippocampal influence in mesial temporal lobe epilepsy measured with high temporal resolution functional magnetic resonance imaging. Epilepsia 52, 1741-1749.
62. Morgan, V. L., Sonmezturk, H. H., Gore, J. C., and Abou-Khalil, B. (2012). Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia 53, 1628-1635.
63. Nelissen, N., Van Paesschen, W., Baete, K., Van Laere, K., Palmini, A., Van Billoen, H., et al. (2006). Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis. Neuroimage 32, 684-695.
64. Peng, H., Long, F., and Ding, C. (2005). Feature selection based on mutual information: criteria of max-dependency, max-relevance, and min-redundancy. IEEE Trans. Pattern Anal. Mach. Intell. 27, 1226-1238.
65. Pereira, F. R., Alessio, A., Sercheli, M. S., Pedro, T., Bilevicius, E., Rondina, J. M., et al. (2010). Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI. BMC Neurosci. 11:66. doi:10.1186/1471-2202-11-66
66. Person, C., Koessler, L., Louis-Dorr, V., Wolf, D., Maillard, L., and Marie, P. Y. (2010). Analysis of the relationship between interictal electrical source imaging and PET hypometabolism. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2010, 3723-3726.
67. Pittau, F., Grova, C., Moeller, F., Dubeau, F., and Gotman, J. (2012). Patterns of altered functional connectivity in mesial temporal lobe epilepsy. Epilepsia 53, 1013-1023.
68. Privitera, M. (2011). Current challenges in the management of epilepsy. Am. J. Manag. Care 17(Suppl. 7), S195-203.
69. Rastogi, S., Lee, C., and Salamon, N. (2008). Neuroimaging in pediatric epilepsy: a multimodality approach. Radiographics 28, 1079-1095.
70. Reuber, M., Fernandez, G., Helmstaedter, C., Qurishi, A., and Elger, C. E. (2002). Evidence of brain abnormality in patients with psychogenic nonepileptic seizures. Epilepsy Behav. 3, 249-254.
71. Reutens, D. C., Stevens, J. M., Kingsley, D., Kendall, B., Moseley, I., Cook, M. J., et al. (1996). Reliability of visual inspection for detection of volumetric hippocampal asymmetry. Neuroradiology 38, 221-225.
72. Rusu, V., Chassoux, F., Landre, E., Bouilleret, V., Nataf, F., Devaux, B. C., et al. (2005). Dystonic posturing in seizures of mesial temporal origin: electroclinical and metabolic patterns. Neurology 65, 1612-1619.
73. Ryvlin, P., Cinotti, L., Froment, J. C., Le Bars, D., Landais, P., Chaze, M., et al. (1991). Metabolic patterns associated with non-specific magnetic resonance imaging abnormalities in temporal lobe epilepsy. Brain 114(Pt 6), 2363-2383.
74. Sadzot, B., Debets, R. M., Maquet, P., Van Veelen, C. W., Salmon, E., Van Emde Boas, W., et al. (1992). Regional brain glucose metabolism in patients with complex partial seizures investigated by intracranial EEG. Epilepsy Res. 12, 121-129.
75. Sahaya, K., Dholakia, S. A., and Sahota, P. K. (2011). Psychogenic non-epileptic seizures: a challenging entity. J. Clin. Neurosci. 18, 1602-1607.
76. Salamon, N., Kung, J., Shaw, S. J., Koo, J., Koh, S., Wu, J. Y., et al. (2008). FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology 71, 1594-1601.
77. Schmidt, M. H., and Pohlmann-Eden, B. (2011). Neuroimaging in epilepsy: the state of the art. Epilepsia 52(Suppl. 4), 49-51.
78. Shehab, S., Simkins, M., Dean, P., and Redgrave, P. (1995). The dorsal midbrain anticonvulsant zone - I. Effects of locally administered excitatory amino acids or bicuculline on maximal electroshock seizures. Neuroscience 65, 671-679.
79. So, E. L., O'Brien, T. J., Brinkmann, B. H., and Mullan, B. P. (2000). The EEG evaluation of single photon emission computed tomography abnormalities in epilepsy. J. Clin. Neurophysiol. 17, 10-28.
80. Sperling, M. R., Gur, R. C., Alavi, A., Gur, R. E., Resnick, S., O'Connor, M. J., et al. (1990). Subcortical metabolic alterations in partial epilepsy. Epilepsia 31, 145-155.
81. Struck, A. F., Hall, L. T., Floberg, J. M., Perlman, S. B., and Dulli, D. A. (2011). Surgical decision making in temporal lobe epilepsy: a comparison of [(18)F]FDG-PET, MRI, and EEG. Epilepsy Behav. 22, 293-297.
82. Swartz, B. E., Tomiyasu, U., Delgado-Escueta, A. V., Mandelkern, M., and Khonsari, A. (1992). Neuroimaging in temporal lobe epilepsy: test sensitivity and relationships to pathology and postoperative outcome. Epilepsia 33, 624-634.
83. Takaya, S., Hanakawa, T., Hashikawa, K., Ikeda, A., Sawamoto, N., Nagamine, T., et al. (2006). Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy. Neurology 67, 1674-1676.
84. Theodore, W. H., Katz, D., Kufta, C., Sato, S., Patronas, N., Smothers, P., et al. (1990). Pathology of temporal lobe foci: correlation with CT, MRI, and PET. Neurology 40, 797-803.
85. Toga, A. W., and Thompson, P. M. (2003). Mapping brain asymmetry. Nat. Rev. Neurosci. 4, 37-48.
86. Uijl, S. G., Leijten, F. S., Arends, J. B., Parra, J., Van Huffelen, A. C., and Moons, K. G. (2007). The added value of [18F]-fluoro-D-deoxyglucose positron emission tomography in screening for temporal lobe epilepsy surgery. Epilepsia 48, 2121-2129.
87. van Ginneken, B., Shaefer-Prokop, C. M., and Prokop, M. (2011). Computer-aided diagnosis: how to move from the laboratory to the clinic. Radiology 261, 719-732.
88. Van Paesschen, W., Duncan, J. S., Stevens, J. M., and Connelly, A. (1998). Longitudinal quantitative hippocampal magnetic resonance imaging study of adults with newly diagnosed partial seizures: one-year follow-up results. Epilepsia 39, 633-639.
89. Wang, Y., Van Klaveren, R. J., De Bock, G. H., Zhao, Y., Vernhout, R., Leusveld, A., et al. (2012). No benefit for consensus double reading at baseline screening for lunch cancer with the use of semiautomated volumetry software. Radiology 262, 320-326.
90. Willmann, O., Wennberg, R., May, T., Woermann, F. G., and Pohlmann-Eden, B. (2007). The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis. Seizure 16, 509-520.
91. Worsley, K. J., Evans, A. C., Marrett, S., and Neelin, P. (1992). A three-dimensional statistical analysis for CBF activation studies in human brain. J. Cereb. Blood Flow Metab. 12, 900-918.
92. Worsley, K. J., Taylor, J. E., Tomaiuolo, F., and Lerch, J. (2004). Unified univariate and multivariate random field theory. Neuroimage 23, S189-S195.
93. Yun, C. H., Lee, S. K., Lee, S. Y., Kim, K. K., Jeong, S. W., and Chung, C. K. (2006). Prognostic factors in neocortical epilepsy surgery: multivariate analysis. Epilepsia 47, 574-579.
94. Zhang, Z., Lu, G., Zhong, Y., Tan, Q., Liao, W., Wang, Z., et al. (2010). Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy. Brain Res. 1323, 152-160.
95. Zhou, J., Gennatas, E. D., Kramer, J. H., Miller, B. L., and Seeley, W. W. (2012). Predicting regional neurodegeneration from the healthy brain functional connectome. Neuron 73, 1216-1227