Synthesis, docking studies, pharmacological activity and toxicity of a novel pyrazole derivative (LQFM 021) - Possible effects on phosphodiesterase

Chemical and Pharmaceutical Bulletin

Volumn 61, Issue 5, 2013, Pages 524-531

  Martins, Daniella Ramos ^a   Pazini, Francine ^a   Alves, Vinícius De Medeiros ^a   De Moura, Soraya Santana ^a   Lião, Luciano Morais ^a   De Magalhães, Mariana Torquato Quezado ^b   Valadares, Marize Campos ^a   Andrade, Carolina Horta ^a   Menegatti, Ricardo ^a   Rocha, Matheus Lavorenti ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA   (Brazil)

Author keywords

Aorta; Cyclic nucleotide; Phosphodiesterase; Pyrazole; Relaxation

Indexed keywords

5 [1 (3 FLUOROPHENYL) 1H PYRAZOL 4YL] 2H TETRAZOLE; ADENOSINE TRIPHOSPHATASE (CALCIUM); CYCLIC NUCLEOTIDE; LQFM 021; PHOSPHODIESTERASE III; PHOSPHODIESTERASE III INHIBITOR; POTASSIUM CHLORIDE; PYRAZOLE DERIVATIVE; TADALAFIL; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD VESSEL REACTIVITY; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG SYNTHESIS; ENDOTHELIUM; ENZYME INHIBITION; FEMALE; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; RAT; TOXICITY TESTING; VASCULAR RING; VASOCONSTRICTION; VASODILATATION;

3T3 CELLS; ANIMALS; CELL SURVIVAL; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEOTIDES, CYCLIC; PYRAZOLES; RATS; RATS, WISTAR; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 84878797783     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-01016     Document Type: Article

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