Cytotoxic activity and apoptosis induction by gaillardin

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 68 C, Issue 3-4, 2013, Pages 108-112

  Moghadam, Maryam Hamzeloo ^a   Naghibi, Farzaneh ^b   Atoofi, Azadeh ^b   Asgharian Rezaie, Mitra ^c   Irani, Mahboobeh ^b   Mosaddegh, Mahmoud ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gaillardin; MTT assay; TUNEL

Indexed keywords

ASTERACEAE; INULA;

EID: 84878782014     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2013-3-405     Document Type: Article

References (13)

1. Alley M. C., Scudiero D. A., Monkes A., Hursey M. L., Czerwinski M. J., Fine D. L., Abbott B. J., Mayo J. G., Shoemaker R. H., and Boyd M. R. (1988), Feasibility of drug screening with panel of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48, 589-601.
2. Bai N., Lai C. S., He K., Zhou Z., Zhang L., Quan Z., Zhu N., Zheng Q. Y., Pan M. H., and Ho C. T. (2006), Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J. Nat. Prod. 69, 531-535.
3. Cheng X. R., Li W. W., Ren J., Zeng Q., Zhang S. D., Shen Y. H., Yan S. K., Ye J., Jin H. Z., and Zhang W. D. (2012), Sesquiterpene lactones from Inula hookeri. Planta Med. 78, 465-471
4. Drew D. P., Krichau N., Reichwald K., and Simonsen H. T. (2008), Guaianolides in Apiaceae: perspectives on pharmacology and biosynthesis. Phytochem. Rev. 8, 581-599.
5. El-Najjar N., Dakdouki S., Darwiche N., El-Sabban M., Saliba N. A., and Gali-Muhtasib H. (2008), Anti-colon cancer effects of salograviolide A isolated from Centaurea ainetensis. Oncol. Rep. 19, 897-904.
6. Fulda S. (2010), Modulation of apoptosis by natural products for cancer therapy. Planta Med. 76, 1075-1079.
7. Gonzalez Romero M. A., Villaescusa Castillo L., Diaz Lanza A. M., Bartolome Esteban C., and Fernandez Matellano L. (2001), Phytochemistry and pharmacological studies of Inula montana L. Recent Res. Dev. Phytochem. 5, 255-268.
8. Hsu Y., Wu L., and Kuo P. (2009), Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells. J. Pharmacol. Exp. Ther. 329, 808-819.
9. Ichikawa H., Nair M. S., Takada Y., Sheeja D., Kumar M., Oommen O. V., and Aggarwal B. B. (2006), Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression. Clin. Cancer Res. 12, 5910-5918.
10. Moghadam M. H., Hajimehdipoor H., Saeidnia S., Atoofi A., Shahrestani R., Read R. W., and Mosaddegh M. (2012), Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana. Nat. Prod. Commun. 7, 979-980.
11. Mosaddegh M., Moghadam M. H., Ghafari S., Naghibi F., Ostad S. N., and Read R. W. (2010), Sesquiterpene lactones from Inula oculus-christi. Nat. Prod. Commun. 5, 511-514.
12. Pratheeshkumar P. and Kuttan G. (2011), Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation. Drug Chem. Toxicol. 34, 261-270.
13. Zeng G. Z., Tan N. H., Ji C. J., Fan J. T., Huang H. Q., Han H. J., and Zhou G. B. (2009), Apoptosis inducement of bigelovin from Inula helianthus-aquatica on human leukemia U937 cells. Phytother. Res. 23, 885-891.