Sesquiterpene lactones from inula hookeri

Planta Medica

Volumn 78, Issue 5, 2012, Pages 465-471

  Cheng, Xiang Rong ^a   Li, Wei Wei ^a   Ren, Jie ^a   Zeng, Qi ^a   Zhang, Shou De ^a   Shen, Yun Heng ^b   Yan, Shi Kai ^a   Ye, Ji ^b   Jin, Hui Zi ^a   Zhang, Wei Dong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

CCK 8 assay; Compositae; cytotoxicity; Inula hookeri; sesquiterpene lactones

Indexed keywords

10ALPHA HYDROXY 8 EPI CONFERTIN; 11(13) DEHYDROIVAXILLIN; 11ALPHA,13 DIHYDROINUVISCOLIDE; 14 ACETOXY 1BETA,7ALPHAH 4BETA HYDROXY GUAI 9(10),11(13) DIEN 12,8ALPHA OLIDE; 2 DESOXY 4 EPI PULCHELLIN; 2,3 DIHYDROAROMATICIN; 2ALPHA ACETOXY INUVISCOLIDE; 4 EPI ISOINUVISCOLIDE; 5ALPHA,6ALPHA EPOXY 2ALPHA ACETOXY 4ALPHA HYDROXY 1BETA,7ALPHA GUAIA 11(13) EN 12,8ALPHA OLIDE; 6 ACETOXY 2 ETHOXY 4 OXO PSEUDOGUAI 11(13) EN 12,8 OLIDE; 6 ACETOXY 2 HYDROXY 4 OXO PSEUDOGUAI 11(13) EN 12,8 OLIDE; 6 ACETOXY 9 HYDROXY 4 OXO PSEUDOGUAI 2(3) EN 12,8 OLIDE; 8 EPI INUVISOLIDE; 8 EPIHELENALIN; AROMATICIN; BIGELOVIN; BURRODIN; CARABRONE; CARPESIOLIN; CHOLECYSTOKININ OCTAPEPTIDE; DOXORUBICIN; ERGOLIDE; GAILLARDIN; GUAIANOLIDE DERIVATIVE; INUCHINENOLIDE B; INUVISCOLIDE; PSEUDOGUAIANOLIDE DERIVATIVE; SESQUITERPENE LACTONE DERIVATIVE; TOMENTOSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HEPG2; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; HELA CELL; HUMAN; HUMAN CELL; INULA HOOKERI; MEDICINAL PLANT; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL ASSAY; CELL LINE, TUMOR; CELL SURVIVAL; CHINA; FEMALE; HUMANS; INULA; LACTONES; MALE; MEDICINE, CHINESE TRADITIONAL; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANTS, MEDICINAL; SESQUITERPENES;

ASTERACEAE; INULA;

EID: 84862796923     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1298147     Document Type: Article

References (33)

1. Zhao Y M., Zhang M L., Shi Q W., Hiromasa K. Chemical consitituents of plants from the genus Inula. Chem Biodivers 2006 3 371-384
2. Committee of Chinese Pharmacopoeia. Pharmacopoeia of the People's Republic of China. 2010 Chinese Edition, Volume 1 Beijing China Medical Science and Technology Press 2010 15 202, 305
3. Nie L Y., Qin J J., Huang Y, Yan L, Liu Y B., Pan Y X., Jin H Z., Zhang W D. Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production. J Nat Prod 2010 73 1117-1120
4. Qin J J., Jin H Z., Zhu J X., Fu J J., Qi Z, Cheng X R., Zhu Y, Shan L, Zhang S D., Pan Y X., Zhang W D. New sesquiterpenes from Inula japonica Thunb. with their inhibitory activities against LPS-induced NO production in RAW264.7 macrophages. Tetrahedron 2010 66 9379-9388
5. Cheng X, Zeng Q, Ren J, Qin J, Zhang S, Shen Y, Zhu J, Zhang F, Chang R, Zhu Y, Zhang W, Jin H. Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents. Eur J Med Chem 2011 46 5408-5415
6. Qin J J., Zhu J X., Zeng Q, Cheng X R., Zhu Y, Zhang S D., Shan L, Jin H Z., Zhang W D. Pseudoguaianolides and guaianolides from Inula hupehensis as potential anti-inflammatory agents. J Nat Prod 2011 74 1881-1887
7. Wang Q, Zhou B N., Zhang R W., Lin Y Y., Lin L Z., Gil R R., Cordell G A. Cytotoxicity and NMR spectral assignments of ergolide and bigelovin. Planta Med 1996 62 166-168 (Pubitemid 26163224)
8. Bohlmann F, Misra L N., Jakupovic J. Pseudoguaianolides and carabrone derivatives from Loxothysanus sinuatus. Phytochemistry 1985 24 1021-1026
9. Romo J, Joseph-Nathan P, Diaz F A. Constituents of Helenium aromaticum. Structures of aromatin and aromaticin. Tetrahedron 1964 20 79-85
10. Maruyama M, Omura S. Carpesiolin from Carpesium abrotanoides. Phytochemistry 1977 16 782-783
11. Lee H T., Yang S W., Kim K H., Seo E K., Mar W. Pseudoguaianolides isolated from Inula britannica var. chinensis as inhibitory constituents against inducible nitric oxide synthase. Arch Pharm Res 2002 25 151-153 (Pubitemid 43057308)
12. Wang F, Yang K, Ren F C., Liu J K. Sesquiterpene lactones from Carpesium abrotanoides. Fitoterapia 2009 80 21-24
13. Geissman T A., Matsueda S. Sesquiterpene lactones. Constituents of diploid and polyploid Ambrosia dumosa Gray. Phytochemistry 1968 7 1613-1621
14. Abdel-Mogib M, Jakupovic J, Dawidar A M., Metwally M A., Abou-Elzahab M. Sesquiterpene lactones and kaurane glycosides from Francoeuria crispa. Phytochemistry 1990 29 2581-2584
15. Bohlmann F, Mahanta P K., Jakupovic J, Rastogi R C., Natu A A. New sesquiterpene lactones from Inula species. Phytochemistry 1978 17 1165-1172
16. Bohlmann F, Czerson H, Schoeneweiss S. New constituents of Inula viscosa Ait. Chem Ber 1977 110 1330-1334
17. Zdero C, Bohlmann F, King R M., Robinson H. Sesquiterpene lactones from Bedfordia arborescens. Phytochemistry 1987 26 1207-1209
18. Jakupovic J, Schuster A, Bohlmann F, King R M., Lander N S. Sesquiterpene lactones from Gnephosis species. Phytochemistry 1988 27 3181-3185
19. Kupchan S M., Cassady J M., Kelsey J E., Schnoes H K., Smith D H., Burlingame A L. Structural elucidation and high-resolution mass spectrometry of gaillardin, new cytotoxic sesquiterpene lactone. J Am Chem Soc 1966 88 5292-5302
20. Ito K, Iida T. Seven sesquiterpene lactones from Inula britannica var. chinensis. Phytochemistry 1981 20 271-273
21. Jakupovic J, Zdero C, Grenz M, Tsichritzis F, Lehmann L, Hashemi-Nejad S M., Bohlmann F. Twenty-one acylphloroglucinol derivatives and further constituents from South African Helichrysum species. Phytochemistry 1989 28 1119-1131
22. AV-. Arch Pharm Res 2004 27 1029-1033
23. Bohlmann F, Umemoto K, Jakupovic J. Pseudoguaianolides related to confertin from Stevia isomeca. Phytochemistry 1985 24 1017-1019
24. Kuo Y H., Lin B Y. A new dinorxanthane and chromone from the root of Tithonia diversifolia. Chem Pharm Bull 1999 47 428-429
25. Ohno S, Tomita-Yokotani K, Kosemura S, Node M, Suzuki T, Amano M, Yasui K, Goto T, Yamamura S, Hasegawa K. A species-selective allelopathic substance from germinating sunflower (Helianthus annuus L.) seeds. Phytochemistry 2001 56 577-581 (Pubitemid 32216496)
26. Lanzetta R, Lama G, Mauriello G, Parrilli M, Racioppi R, Sodano G. Ichthyotoxic sesquiterpenes and xanthanolides from Dittrichia graveolens. Phytochemistry 1991 30 1121-1124
27. Maruyama M, Karube A, Sato K. Sesquiterpene lactones from Carpesium abrotanoides. Phytochemistry 1983 22 2773-2774
28. 15-androsten-17-ones. J Am Chem Soc 1960 82 3209-3214
29. Stöchlin W, Waddell T G., Geissman T A. Circular dichroism and optical rotator dispersion of sesquiterpene lactones. Tetrahedron 1970 26 2397-2410
30. Chekholv A N. Crystal structure and absolute configuration of 6 -acetoxy 4-oxo-(1 H,7 H,8 H,10 H)-15(4 5 )abeo-guaia-2, 11(13)-dien-8, 12-olide. J Struct Chem 2000 41 1084-1087
31. Brito I, Bórquez J, Loyola L A., López-Rodríguez M. Aromaticine, a sesquiterpene lactone from Amblyopappus pusillus. Acta Crystallogr 2008 E64 o529 (Pubitemid 351224654)
32. Pal H C., Sehar I, Bhushan S, Gupta B D., Saxena A K. Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa. Toxicol In Vitro 2010 24 1599-1609
33. Park E J., Kim J. Cytotoxic sesquiterpene lactones from Inula britannica. Planta Med 1998 64 752-754 (Pubitemid 29021577)